Development Level

Tclin 8 | 613
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 2 | 278
abnormal gait 1 | 69
embryonic lethality prior to o... 1 | 239
impaired glucose tolerance 1 | 75
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 8 | 11,493
Schizophrenia 5 | 1,160
group 3 medulloblastoma 5 | 4,104
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
ovarian cancer 5 | 8,520
psoriasis 5 | 6,694
Asthma 4 | 385
Autosomal recessive predisposition 4 | 1,442
Cancer 4 | 2,499
Mood Disorders 4 | 184
Renal Cell Carcinoma 4 | 214
Stomach Neoplasms 4 | 300
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
osteosarcoma 4 | 7,950
primitive neuroectodermal tumor 4 | 3,035
Breast cancer 3 | 3,578
Heart disease 3 | 306
Hypotension 3 | 82
Kidney cancer 3 | 2,613
Liver Cirrhosis 3 | 181
Malignant hyperthermia 3 | 26
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Myopathy 3 | 185
Parkinson's disease 3 | 392
Reperfusion Injury 3 | 86
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
astrocytic glioma 3 | 2,597
glioblastoma 3 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
Acute kidney injury 2 | 70
Alcoholic Intoxication, Chronic 2 | 289
Allergic rhinitis 2 | 94
Alzheimer's disease 2 | 658
Anemia 2 | 365
Arthritis 2 | 290
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Autism spectrum disorder 2 | 101
Bipolar Disorder 2 | 666
Breast Neoplasms 2 | 445
Bronchitis 2 | 43
Carcinoma, Hepatocellular 2 | 228
Cardiomyopathies 2 | 110
Cerebrovascular disease 2 | 238
Chronic obstructive pulmonary disease 2 | 184
Coronary artery disease 2 | 268
Crohn Disease 2 | 45
Depressive disorder 2 | 409
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diarrhea 2 | 253
Endometrial cancer 2 | 311
Endometriosis 2 | 540
Failure to gain weight 2 | 365
Fever 2 | 138
Heart failure 2 | 162
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hip Dislocation, Congenital 2 | 48
Hypertension 2 | 396
Inflammation 2 | 120
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Lipid metabolism disorder 2 | 114
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Liver carcinoma 2 | 240
Liver disease 2 | 237
Malaria 2 | 160
Mammary Neoplasms 2 | 425
Mental Depression 2 | 333
Mesothelioma, Malignant 2 | 105
Myocardial Infarction 2 | 151
Myocardial Ischemia 2 | 169
Neuropathy 2 | 261
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Phenotypic variability 2 | 150
Pick disease 2 | 1,894
Pneumonia 2 | 174
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Recurrent respiratory infections 2 | 141
Spasticity 2 | 26
Tachycardia 2 | 43
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 2 | 4,145
Epigenetic 2 | 242
Ion Channel 2 | 344
GPCR 1 | 408
Kinase 1 | 634
Non-IDG 1 | 12,091
Nuclear Receptor 1 | 48

GO Process

response to caffeine 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dihydroorotate dehydrogenase (quinone), mitochondrial DHODH Tclin Enzyme -2.47702 295.8 225
Ryanodine receptor 2 RYR2 Tclin Ion Channel -2.92980 851.9 138
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
DNA (cytosine-5)-methyltransferase 3B DNMT3B Tchem Epigenetic -2.73137 480.9 350
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.77923 382.8 271
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773
Adenosine receptor A2a ADORA2A Tclin GPCR -2.98333 954.1 244
Histone deacetylase 2 HDAC2 Tclin Epigenetic -2.79651 587.9 712
5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 Tchem Kinase -1.92824 74.3 953