Development Level

Tbio 29 | 11,445
Tchem 9 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal retina morphology 2 | 71
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal gait 1 | 69
abnormal hair texture 1 | 4
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased circulating triglyce... 1 | 79
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
limb grasping 1 | 41
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 29 | 11,493
osteosarcoma 25 | 7,950
ovarian cancer 25 | 8,520
glioblastoma 19 | 5,792
lung cancer 15 | 4,740
Cancer 14 | 2,499
atypical teratoid / rhabdoid tumor 14 | 5,112
group 3 medulloblastoma 14 | 4,104
medulloblastoma, large-cell 14 | 6,241
psoriasis 14 | 6,694
ependymoma 13 | 4,679
Breast cancer 12 | 3,578
primitive neuroectodermal tumor 12 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Autosomal recessive predisposition 10 | 1,442
Kidney cancer 10 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
oligodendroglioma 10 | 2,850
Cryptorchidism 9 | 296
Cockayne syndrome 8 | 60
Dry skin 8 | 75
Freckles 8 | 33
Hypogonadism 8 | 173
Sensorineural Hearing Loss (disorder) 8 | 284
Xerosis 8 | 75
adult high grade glioma 8 | 3,801
astrocytic glioma 8 | 2,597
non-small cell lung cancer 8 | 2,890
Dull intelligence 7 | 645
Fatigue 7 | 182
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Poor school performance 7 | 645
Strabismus 7 | 270
malignant mesothelioma 7 | 3,232
Atrophic condition of skin 6 | 25
Basal cell carcinoma 6 | 54
Cataract 6 | 297
Epilepsy 6 | 792
Lens Opacities 6 | 231
Melanoma 6 | 711
Optic Atrophy 6 | 242
Photosensitivity of skin 6 | 51
Pick disease 6 | 1,894
Seizures 6 | 596
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
pediatric high grade glioma 6 | 1,064
Basal cell nevi 5 | 23
Cerebellar Ataxia 5 | 304
Failure to gain weight 5 | 365
Fever 5 | 138
Hyperpigmented macules 5 | 42
Keratitis 5 | 62
Pediatric failure to thrive 5 | 365
Poikiloderma 5 | 14
Schizophrenia 5 | 1,160
Short stature 5 | 531
Small head 5 | 374
Xeroderma pigmentosum 5 | 43
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
nasopharyngeal carcinoma 5 | 1,058
pituitary cancer 5 | 1,972
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Deafness 4 | 198
Developmental regression 4 | 95
Electroencephalogram abnormal 4 | 101
Impaired cognition 4 | 96
Increase in blood pressure 4 | 119
Infantile onset 4 | 238
Loss of developmental milestones 4 | 95
Low Vision 4 | 174
Mental deterioration in childhood 4 | 95
Mental impairment 4 | 95
Muscle Spasticity 4 | 195
Neurodevelopmental regression 4 | 95
Osteoporosis 4 | 363
Psychomotor regression 4 | 95
Psychomotor regression beginning in infancy 4 | 95
Psychomotor regression in infants 4 | 95
Psychomotor regression, progressive 4 | 95
Retinal Diseases 4 | 55
Stomach Neoplasms 4 | 300
Thin skin 4 | 47
Visual Impairment 4 | 174
Waldenstrons macroglobulinemia 4 | 765
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
hearing impairment 4 | 199
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Skin and soft tissues 42 | 17,230
Blood and immune system 41 | 16,909
Digestive Tract 41 | 17,369
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Urinary Tract 41 | 16,678
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 22 | 12,091
Enzyme 13 | 4,145
Kinase 5 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

response to UV 42 | 42
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA annealing helicase and endonuclease ZRANB3 ZRANB3 Tbio Enzyme -2.18014 154.3 36
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.53597 32.3 117
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
Tumor protein p53-inducible protein 13 TP53I13 Tdark Non-IDG 0.26 0.47 63
Tyrosinase TYR Tclin Enzyme -3.32888 2021.2 494
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
DNA repair protein complementing XP-G cells ERCC5 Tchem Enzyme -2.06679 113.9 255
DNA repair protein REV1 REV1 Tbio Non-IDG -2.43956 286.1 101
Ubiquitin conjugation factor E4 B UBE4B Tbio Non-IDG -1.86207 73.2 141
Serine/threonine-protein kinase BRSK1 BRSK1 Tchem Kinase -1.44039 28.9 301