Development Level

Tbio 22 | 11,651
Tchem 9 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased lean body mass 1 | 135
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hypoactivity 1 | 132
increased basophil cell number 1 | 7
increased eosinophil cell numb... 1 | 11
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 21 | 8,520
Carcinoma 19 | 11,493
glioblastoma 18 | 5,792
Cancer 17 | 2,499
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
ependymoma 13 | 4,679
lung cancer 13 | 4,740
Astrocytoma, Pilocytic 10 | 3,081
atypical teratoid / rhabdoid tumor 10 | 5,112
tuberculosis 10 | 2,010
adult high grade glioma 9 | 3,801
lung carcinoma 9 | 2,843
medulloblastoma, large-cell 8 | 6,241
oligodendroglioma 7 | 2,850
subependymal giant cell astrocytoma 7 | 2,287
Multiple myeloma 6 | 1,332
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
ulcerative colitis 6 | 1,819
Bipolar Disorder 5 | 666
Kidney cancer 5 | 2,613
Rheumatoid arthritis 5 | 1,191
Waldenstrons macroglobulinemia 5 | 765
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
juvenile dermatomyositis 5 | 1,187
malignant mesothelioma 5 | 3,232
Alzheimer's disease 4 | 658
Anemia 4 | 365
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
Carcinoma, Hepatocellular 4 | 228
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Multiple Sclerosis 4 | 540
Pick disease 4 | 1,894
Stomach Neoplasms 4 | 300
Type 2 diabetes mellitus 4 | 272
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
primitive neuroectodermal tumor 4 | 3,035
Adenocarcinoma 3 | 122
Amyotrophic lateral sclerosis 3 | 451
Arthritis 3 | 290
Arthritis, Rheumatoid 3 | 174
Asthma 3 | 385
Breast Neoplasms 3 | 445
Carcinoma, Non-Small-Cell Lung 3 | 107
Colorectal Neoplasms 3 | 243
Crohn's disease 3 | 321
Dermatitis 3 | 157
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Edema 3 | 81
Failure to gain weight 3 | 365
Fever 3 | 138
Hypersensitivity reaction type II disease 3 | 253
Inflammatory bowel disease 3 | 151
Juvenile rheumatoid arthritis 3 | 111
Leukemia 3 | 104
Liver Cirrhosis, Experimental 3 | 769
Mammary Neoplasms 3 | 425
Melanoma 3 | 711
Pediatric failure to thrive 3 | 365
Pneumonia 3 | 174
Systemic lupus erythematosus 3 | 194
group 4 medulloblastoma 3 | 1,855
hepatocellular carcinoma 3 | 547
non-small cell lung cancer 3 | 2,890
non-small cell lung carcinoma 3 | 317
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
Bladder Neoplasm 2 | 112
Brain Ischemia 2 | 110
Dermatitis, Allergic Contact 2 | 67
Diarrhea 2 | 253
Epilepsy 2 | 792
Hypertension 2 | 396
Kidney disease 2 | 430
Leishmaniasis 2 | 47
Listeriosis 2 | 18
Lung disease 2 | 142
Reperfusion Injury 2 | 86
Seizures 2 | 596
Status Epilepticus 2 | 98
Toxic encephalopathy 2 | 141
Urinary Bladder Neoplasms 2 | 114
active ulcerative colitis 2 | 764

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 7 | 4,145
Kinase 7 | 634

GO Process

regulation of tumor necrosis f... 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 Tbio Non-IDG -1.58319 39.4 224
Homeodomain-interacting protein kinase 1 HIPK1 Tbio Kinase -0.65413 5.10 194
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518
Receptor of activated protein C kinase 1 RACK1 Tbio Non-IDG -2.60480 437.9 300
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.62553 373.2 500
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351