Development Level

Tbio 246 | 10,625
Tdark 42 | 7,003
Tchem 33 | 1,890
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 13 | 633
abnormal behavior 9 | 226
preweaning lethality, incomple... 8 | 260
abnormal embryo size 4 | 112
decreased lean body mass 4 | 195
decreased leukocyte cell numbe... 4 | 54
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
decreased bone mineral density 3 | 126
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
hyperactivity 3 | 108
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
short tibia 3 | 82
abnormal eye morphology 2 | 38
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
abnormal tooth morphology 2 | 24
anophthalmia 2 | 20
corneal opacity 2 | 25
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating free fat... 2 | 39
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased B cell number 2 | 23
increased Ly6C high monocyte n... 2 | 12
increased circulating serum al... 2 | 25
increased exploration in new e... 2 | 56
microphthalmia 2 | 15
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal craniofacial morpholo... 1 | 12
abnormal eye size 1 | 11
abnormal forelimb morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
absent heartbeat 1 | 6
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased macrophage cell numb... 1 | 4
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating potassiu... 1 | 31
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
pale yolk sac 1 | 12
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
small spleen 1 | 11
small superior vagus ganglion 1 | 20
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 183 | 8,484
osteosarcoma 166 | 7,933
psoriasis 139 | 6,685
medulloblastoma, large-cell 134 | 6,234
glioblastoma 114 | 5,572
lung cancer 96 | 4,466
atypical teratoid / rhabdoid tumor 95 | 4,369
malignant mesothelioma 83 | 3,162
Cancer 76 | 2,346
Breast cancer 73 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,289
primitive neuroectodermal tumor 57 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,988
pediatric high grade glioma 53 | 2,712
invasive ductal carcinoma 51 | 2,950
lung adenocarcinoma 51 | 2,713
group 3 medulloblastoma 47 | 2,254
oligodendroglioma 47 | 2,849
group 4 medulloblastoma 45 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,956
non-small cell lung cancer 44 | 2,798
Multiple myeloma 42 | 1,327
subependymal giant cell astrocytoma 42 | 2,287
lung carcinoma 40 | 2,844
medulloblastoma 40 | 1,524
pancreatic cancer 40 | 2,300
astrocytoma 39 | 1,493
ulcerative colitis 39 | 2,087
ependymoma 38 | 2,514
interstitial cystitis 38 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,795
Pick disease 37 | 1,893
astrocytic glioma 37 | 2,241
pilocytic astrocytoma 37 | 3,086
Rheumatoid Arthritis 36 | 1,160
adult high grade glioma 36 | 2,148
diabetes mellitus 36 | 1,663
Carcinoma 34 | 2,147
juvenile dermatomyositis 34 | 1,189
pituitary cancer 34 | 1,972
tuberculosis 34 | 1,557
dermatomyositis 33 | 933
cystic fibrosis 31 | 1,665
colon cancer 30 | 1,475
primary pancreatic ductal adenocarcinoma 29 | 1,271
acute quadriplegic myopathy 27 | 1,157
breast carcinoma 26 | 1,614
ductal carcinoma in situ 26 | 1,745
adrenocortical carcinoma 25 | 1,427
sonic hedgehog group medulloblastoma 25 | 1,482
posterior fossa group A ependymoma 22 | 1,511
primary Sjogren syndrome 22 | 789
Obesity 21 | 616
Waldenstrons macroglobulinemia 21 | 765
Intellectual disability 20 | 573
spina bifida 20 | 1,064
aldosterone-producing adenoma 18 | 664
Down syndrome 17 | 548
active Crohn's disease 17 | 918
acute myeloid leukemia 17 | 780
cutaneous lupus erythematosus 17 | 1,056
nasopharyngeal carcinoma 17 | 1,056
posterior fossa group B ependymoma 17 | 1,530
Atopic dermatitis 15 | 944
pancreatic carcinoma 15 | 567
Endometriosis 14 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
atypical teratoid/rhabdoid tumor 13 | 1,095
gastric carcinoma 13 | 832
hepatocellular carcinoma 13 | 532
non primary Sjogren syndrome sicca 13 | 840
tuberculosis and treatment for 6 months 13 | 686
Mammary Neoplasms 12 | 410
esophageal adenocarcinoma 12 | 737
progressive supranuclear palsy 12 | 674
Alzheimer's disease 11 | 644
Amyotrophic Lateral Sclerosis 11 | 431
Acquired metabolic disease 10 | 267
Myocardial Ischemia 10 | 169
Peripheral Neuropathy 10 | 303
Prostatic Neoplasms 10 | 471
Stomach Neoplasms 10 | 282
hereditary spastic paraplegia 10 | 313
Cleft palate 9 | 125
Kidney disease 9 | 396
Polycystic Ovary Syndrome 9 | 332
Schizophrenia 9 | 501
gastric cancer 9 | 430
non-small cell lung carcinoma 9 | 413
ovarian neoplasm 9 | 97
Adenoid Cystic Carcinoma 8 | 99
Duchenne muscular dystrophy 8 | 602
Juvenile arthritis 8 | 124
Liver carcinoma 8 | 217
Parkinson's disease 8 | 364
active ulcerative colitis 8 | 477
chronic rhinosinusitis 8 | 512
inflammatory breast cancer 8 | 404
mucosa-associated lymphoid tissue lymphoma 8 | 480
tuberculosis and treatment for 3 months 8 | 327

Tissue

Female tissues 324 | 18,647
Nervous System 324 | 18,561
Digestive Tract 323 | 18,473
Endocrine System 323 | 18,512
Skin and soft tissues 321 | 18,115
Urinary Tract 321 | 18,444
Cardiovascular System 319 | 17,958
Liver and Pancreas 318 | 18,136
Male tissues 318 | 17,969
Blood and immune system 317 | 17,995
Respiratory system 313 | 17,484

Target Family

Transcription Factor 160 | 1,400
Non-IDG 99 | 11,971
Enzyme 27 | 4,146
Epigenetic 18 | 242
Kinase 6 | 634
Nuclear Receptor 5 | 48
TF/Epigenetic 5 | 38
Transporter 2 | 473
GPCR 1 | 406
Ion Channel 1 | 341

GO Process

regulation of transcription fr... 324 | 324
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
BarH-like 1 homeobox protein BARHL1 Tbio Transcription Factor -1.06351 11.8 78
Zinc finger protein 367 ZNF367 Tbio Transcription Factor 0.02 1.24 64
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Zinc finger protein 865 ZNF865 Tdark Transcription Factor 0.00000 30
Krueppel-like factor 9 KLF9 Tbio Transcription Factor -1.87911 88.8 139
Zinc finger BED domain-containing protein 6 ZBED6 Tdark Non-IDG -0.79472 9.28 0