Development Level

Tbio 561 | 11,178
Tdark 475 | 6,569
Tchem 89 | 1,885
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 70 | 979
preweaning lethality, incomple... 30 | 499
embryonic lethality prior to t... 25 | 278
embryonic lethality prior to o... 21 | 239
abnormal embryo size 18 | 220
abnormal behavior 13 | 298
decreased lean body mass 11 | 135
decreased total body fat amoun... 11 | 207
increased lean body mass 10 | 172
increased startle reflex 10 | 112
increased total body fat amoun... 10 | 134
abnormal bone structure 9 | 187
decreased body weight 9 | 161
decreased grip strength 9 | 116
decreased vertical activity 9 | 208
decreased circulating serum al... 8 | 82
enlarged heart 8 | 210
hypoactivity 8 | 132
abnormal heart morphology 7 | 162
hyperactivity 7 | 148
increased circulating alkaline... 7 | 122
increased or absent threshold ... 7 | 101
male infertility 7 | 123
abnormal eye morphology 6 | 68
decreased mean corpuscular vol... 6 | 79
embryonic growth retardation 6 | 106
impaired glucose tolerance 6 | 75
improved glucose tolerance 6 | 79
increased bone mineral content 6 | 108
increased mean corpuscular hem... 6 | 96
abnormal gait 5 | 69
abnormal neural tube closure 5 | 46
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased circulating choleste... 5 | 93
decreased circulating total pr... 5 | 49
decreased erythrocyte cell num... 5 | 62
decreased fasted circulating g... 5 | 65
increased bone mineral density 5 | 72
prenatal lethality prior to he... 5 | 87
short tibia 5 | 97
small superior vagus ganglion 5 | 74
small testis 5 | 58
abnormal forebrain development 4 | 20
decreased body length 4 | 101
decreased bone mineral density 4 | 126
decreased caudal vertebrae num... 4 | 53
decreased circulating alanine ... 4 | 47
decreased circulating triglyce... 4 | 79
decreased neutrophil cell numb... 4 | 42
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased circulating triglyce... 4 | 42
pale yolk sac 4 | 25
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal midbrain development 3 | 20
abnormal retina morphology 3 | 71
abnormal testis morphology 3 | 43
abnormal tooth morphology 3 | 24
decreased bone mineral content 3 | 151
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased circulating amylase ... 3 | 28
decreased circulating fructosa... 3 | 30
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased heart left ventricle... 3 | 28
decreased mean platelet volume 3 | 25
enlarged spleen 3 | 41
hydrometra 3 | 53
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 36
increased mean platelet volume 3 | 45
pallor 3 | 34
prolonged QRS complex duration 3 | 8
thin ventricular wall 3 | 24
vertebral transformation 3 | 12
abnormal behavioral response t... 2 | 66
abnormal cranium morphology 2 | 36
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
corneal opacity 2 | 32
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
increased body length 2 | 32
increased circulating aspartat... 2 | 15
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
long tibia 2 | 25
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 773 | 11,192
osteosarcoma 519 | 7,766
ovarian cancer 477 | 8,297
medulloblastoma, large-cell 334 | 6,086
glioblastoma 304 | 5,635
psoriasis 298 | 6,514
group 3 medulloblastoma 286 | 4,002
atypical teratoid / rhabdoid tumor 268 | 4,971
lung cancer 265 | 4,607
ependymoma 219 | 4,559
Kidney cancer 189 | 2,548
primitive neuroectodermal tumor 182 | 2,957
Breast cancer 181 | 3,469
malignant mesothelioma 180 | 3,135
adult high grade glioma 165 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,204
oligodendroglioma 147 | 2,768
Cancer 139 | 2,388
intraductal papillary-mucinous carcinoma (IPMC) 137 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 129 | 2,872
astrocytic glioma 124 | 2,530
group 4 medulloblastoma 124 | 1,806
Astrocytoma, Pilocytic 110 | 3,006
Pick disease 101 | 1,856
lung carcinoma 95 | 2,755
invasive ductal carcinoma 94 | 2,867
pancreatic cancer 90 | 2,322
tuberculosis 90 | 1,963
subependymal giant cell astrocytoma 88 | 2,230
adrenocortical carcinoma 86 | 1,385
non-small cell lung cancer 83 | 2,799
interstitial cystitis 82 | 2,237
lung adenocarcinoma 80 | 2,627
pancreatic ductal adenocarcinoma liver metastasis 75 | 1,911
pituitary cancer 75 | 1,915
spina bifida 73 | 1,053
Multiple myeloma 71 | 1,296
astrocytoma 71 | 1,113
diabetes mellitus 70 | 1,683
Rheumatoid arthritis 67 | 1,156
juvenile dermatomyositis 66 | 1,147
acute quadriplegic myopathy 63 | 1,133
cystic fibrosis 63 | 1,629
pediatric high grade glioma 63 | 1,035
breast carcinoma 59 | 1,589
acute myeloid leukemia 56 | 760
colon cancer 55 | 1,428
ulcerative colitis 53 | 1,765
ductal carcinoma in situ 52 | 1,686
Intellectual disability 51 | 998
Schizophrenia 50 | 1,136
non primary Sjogren syndrome sicca 49 | 861
dermatomyositis 47 | 941
Waldenstrons macroglobulinemia 45 | 742
hepatocellular carcinoma 43 | 536
primary pancreatic ductal adenocarcinoma 41 | 1,071
medulloblastoma 40 | 702
tuberculosis and treatment for 6 months 40 | 399
Breast Neoplasms 36 | 423
Mammary Neoplasms 36 | 403
Obesity 36 | 655
aldosterone-producing adenoma 36 | 646
progressive supranuclear palsy 36 | 656
cutaneous lupus erythematosus 34 | 1,016
Short stature 33 | 514
active Crohn's disease 33 | 882
primary Sjogren syndrome 32 | 710
Liver cancer 31 | 589
gastric cancer 31 | 445
nasopharyngeal carcinoma 31 | 1,024
Prostatic Neoplasms 30 | 472
pancreatic carcinoma 30 | 555
sonic hedgehog group medulloblastoma 30 | 459
Alzheimer's disease 29 | 640
Dull intelligence 29 | 634
Low intelligence 29 | 634
Melanoma 29 | 689
Mental Retardation 29 | 634
Mental deficiency 29 | 634
Poor school performance 29 | 634
Amyotrophic lateral sclerosis 28 | 437
active ulcerative colitis 28 | 736
Autosomal recessive predisposition 27 | 1,407
Cognitive delay 27 | 596
Epilepsy 27 | 775
Global developmental delay 27 | 596
Mental and motor retardation 27 | 596
Polycystic ovary syndrome 27 | 348
Atopic dermatitis 26 | 915
Muscle hypotonia 26 | 562
gastric carcinoma 26 | 781
Acquired metabolic disease 25 | 329
Bipolar Disorder 24 | 646
Orbital separation excessive 24 | 240
Broad flat nasal bridge 23 | 232
Nasal bridge wide 23 | 232
Seizures 23 | 584
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 492
Mandibular hypoplasia 22 | 273
Micrognathism 22 | 273

Tissue

Endocrine System 1,077 | 18,159
Skin and soft tissues 1,041 | 17,230
Female tissues 1,039 | 17,400
Digestive Tract 1,037 | 17,369
Male tissues 1,032 | 17,142
Nervous System 1,026 | 16,725
Blood and immune system 1,024 | 16,909
Urinary Tract 1,013 | 16,678
Liver and Pancreas 1,008 | 16,750
Respiratory system 1,002 | 16,393
Cardiovascular System 976 | 15,192

Target Family

Transcription Factor 600 | 1,400
Non-IDG 348 | 12,091
Epigenetic 64 | 242
Enzyme 59 | 4,145
Kinase 31 | 634
TF/Epigenetic 14 | 38
Nuclear Receptor 12 | 48
GPCR 3 | 408
Transporter 3 | 473
oGPCR 1 | 421

GO Process

regulation of transcription, D... 1,135 | 1,135
transcription, DNA-templated 1,742 | 1,742
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Zinc finger protein 526 ZNF526 Tdark Transcription Factor 0.70 0.20 51
Protein SOX-15 SOX15 Tbio Transcription Factor -1.31464 23.3 166
Protein atonal homolog 7 ATOH7 Tbio Transcription Factor -3.08645 1060.6 178
Zinc finger protein 470 ZNF470 Tdark Transcription Factor -1.12959 14.5 10
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159
Protein SSX4 SSX4 Tbio Non-IDG -1.23634 10.5 148
Protein SSX5 SSX5 Tdark Non-IDG -0.42114 1.53 177
Protein lin-28 homolog A LIN28A Tbio Transcription Factor -2.44709 277.0 494