Development Level

Tbio 568 | 11,445
Tdark 474 | 6,588
Tchem 83 | 1,598
Tclin 10 | 613

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 70 | 979
preweaning lethality, incomple... 30 | 499
embryonic lethality prior to t... 25 | 278
embryonic lethality prior to o... 21 | 239
abnormal embryo size 18 | 220
abnormal behavior 13 | 298
decreased lean body mass 11 | 135
decreased total body fat amoun... 11 | 207
increased lean body mass 10 | 172
increased startle reflex 10 | 112
increased total body fat amoun... 10 | 134
abnormal bone structure 9 | 187
decreased body weight 9 | 161
decreased grip strength 9 | 116
decreased vertical activity 9 | 208
decreased circulating serum al... 8 | 82
enlarged heart 8 | 210
hypoactivity 8 | 132
abnormal heart morphology 7 | 162
hyperactivity 7 | 148
increased circulating alkaline... 7 | 122
increased or absent threshold ... 7 | 101
male infertility 7 | 123
abnormal eye morphology 6 | 68
decreased mean corpuscular vol... 6 | 79
embryonic growth retardation 6 | 106
impaired glucose tolerance 6 | 75
improved glucose tolerance 6 | 79
increased bone mineral content 6 | 108
increased mean corpuscular hem... 6 | 96
abnormal gait 5 | 69
abnormal neural tube closure 5 | 46
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased circulating choleste... 5 | 93
decreased circulating total pr... 5 | 49
decreased erythrocyte cell num... 5 | 62
decreased fasted circulating g... 5 | 65
increased bone mineral density 5 | 72
prenatal lethality prior to he... 5 | 87
short tibia 5 | 97
small superior vagus ganglion 5 | 74
small testis 5 | 58
abnormal forebrain development 4 | 20
decreased body length 4 | 101
decreased bone mineral density 4 | 126
decreased caudal vertebrae num... 4 | 53
decreased circulating alanine ... 4 | 47
decreased circulating triglyce... 4 | 79
decreased neutrophil cell numb... 4 | 42
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased circulating triglyce... 4 | 42
pale yolk sac 4 | 25
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal midbrain development 3 | 20
abnormal retina morphology 3 | 71
abnormal testis morphology 3 | 43
abnormal tooth morphology 3 | 24
decreased bone mineral content 3 | 151
decreased circulating HDL chol... 3 | 68
decreased circulating alkaline... 3 | 46
decreased circulating amylase ... 3 | 28
decreased circulating fructosa... 3 | 30
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased heart left ventricle... 3 | 28
decreased mean platelet volume 3 | 25
enlarged spleen 3 | 41
hydrometra 3 | 53
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 36
increased mean platelet volume 3 | 45
pallor 3 | 34
prolonged QRS complex duration 3 | 8
thin ventricular wall 3 | 24
vertebral transformation 3 | 12
abnormal behavioral response t... 2 | 66
abnormal cranium morphology 2 | 36
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
corneal opacity 2 | 32
decreased circulating LDL chol... 2 | 38
decreased circulating calcium ... 2 | 36
increased body length 2 | 32
increased circulating aspartat... 2 | 15
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
long tibia 2 | 25
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 791 | 11,493
osteosarcoma 534 | 7,950
ovarian cancer 493 | 8,520
medulloblastoma, large-cell 351 | 6,241
glioblastoma 317 | 5,792
psoriasis 306 | 6,694
group 3 medulloblastoma 296 | 4,104
atypical teratoid / rhabdoid tumor 281 | 5,112
lung cancer 275 | 4,740
ependymoma 225 | 4,679
Kidney cancer 195 | 2,613
primitive neuroectodermal tumor 191 | 3,035
malignant mesothelioma 187 | 3,232
Breast cancer 184 | 3,578
adult high grade glioma 170 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 161 | 3,291
oligodendroglioma 154 | 2,850
Cancer 150 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 145 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 136 | 2,955
astrocytic glioma 132 | 2,597
group 4 medulloblastoma 127 | 1,855
Astrocytoma, Pilocytic 114 | 3,081
Pick disease 101 | 1,894
invasive ductal carcinoma 101 | 2,951
lung carcinoma 98 | 2,843
pancreatic cancer 94 | 2,398
subependymal giant cell astrocytoma 93 | 2,287
tuberculosis 91 | 2,010
non-small cell lung cancer 90 | 2,890
adrenocortical carcinoma 88 | 1,428
interstitial cystitis 88 | 2,312
lung adenocarcinoma 84 | 2,716
pituitary cancer 80 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 78 | 1,962
spina bifida 75 | 1,074
diabetes mellitus 73 | 1,728
Multiple myeloma 72 | 1,332
astrocytoma 72 | 1,146
Rheumatoid arthritis 68 | 1,191
cystic fibrosis 68 | 1,696
juvenile dermatomyositis 68 | 1,187
acute quadriplegic myopathy 66 | 1,158
pediatric high grade glioma 66 | 1,064
breast carcinoma 62 | 1,638
colon cancer 60 | 1,478
acute myeloid leukemia 57 | 783
ductal carcinoma in situ 55 | 1,745
ulcerative colitis 54 | 1,819
Intellectual disability 53 | 1,016
Schizophrenia 52 | 1,160
non primary Sjogren syndrome sicca 50 | 891
dermatomyositis 48 | 966
Waldenstrons macroglobulinemia 46 | 765
hepatocellular carcinoma 44 | 547
primary pancreatic ductal adenocarcinoma 43 | 1,109
medulloblastoma 42 | 720
tuberculosis and treatment for 6 months 41 | 409
Obesity 38 | 678
aldosterone-producing adenoma 38 | 665
Breast Neoplasms 36 | 445
Mammary Neoplasms 36 | 425
active Crohn's disease 36 | 922
progressive supranuclear palsy 36 | 676
Short stature 35 | 531
cutaneous lupus erythematosus 34 | 1,057
nasopharyngeal carcinoma 34 | 1,058
primary Sjogren syndrome 34 | 735
gastric cancer 33 | 459
Liver cancer 32 | 604
Epilepsy 31 | 792
Prostatic Neoplasms 31 | 495
active ulcerative colitis 31 | 764
sonic hedgehog group medulloblastoma 31 | 467
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Poor school performance 30 | 645
pancreatic carcinoma 30 | 562
Alzheimer's disease 29 | 658
Amyotrophic lateral sclerosis 29 | 451
Autosomal recessive predisposition 29 | 1,442
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Melanoma 29 | 711
Mental and motor retardation 29 | 608
Muscle hypotonia 29 | 571
Bipolar Disorder 28 | 666
Polycystic ovary syndrome 28 | 360
Atopic dermatitis 27 | 952
Seizures 27 | 596
gastric carcinoma 27 | 807
Acquired metabolic disease 25 | 336
Orbital separation excessive 25 | 244
autosomal dominant Emery-Dreifuss muscular dystrophy 25 | 510
Broad flat nasal bridge 24 | 236
Nasal bridge wide 24 | 236
Strabismus 24 | 270
atypical teratoid/rhabdoid tumor 24 | 357

Tissue

Endocrine System 1,077 | 18,159
Skin and soft tissues 1,041 | 17,230
Female tissues 1,039 | 17,400
Digestive Tract 1,037 | 17,369
Male tissues 1,032 | 17,142
Nervous System 1,026 | 16,725
Blood and immune system 1,024 | 16,909
Urinary Tract 1,013 | 16,678
Liver and Pancreas 1,008 | 16,750
Respiratory system 1,002 | 16,393
Cardiovascular System 976 | 15,192

Target Family

Transcription Factor 600 | 1,400
Non-IDG 348 | 12,091
Epigenetic 64 | 242
Enzyme 59 | 4,145
Kinase 31 | 634
TF/Epigenetic 14 | 38
Nuclear Receptor 12 | 48
GPCR 3 | 408
Transporter 3 | 473
oGPCR 1 | 421

GO Process

regulation of transcription, D... 1,135 | 1,135
transcription, DNA-templated 1,742 | 1,742
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Y-box-binding protein 2 YBX2 Tbio Transcription Factor -1.99119 94.8 236
Putative pituitary tumor-transforming gene 3 protein PTTG3P Tdark Non-IDG 0.00000 0
Securin-2 PTTG2 Tdark Non-IDG -0.58734 3.76 86
Homeobox protein notochord NOTO Tdark Transcription Factor -2.36366 209.2 26
Zinc finger protein 134 ZNF134 Tdark Transcription Factor -0.11090 1.20 158
Lysine-specific demethylase hairless HR Tbio Enzyme -1.13301 12.4 99
TFIIA-alpha and beta-like factor GTF2A1L Tbio Non-IDG -0.66901 3.86 222
Zinc finger protein 142 ZNF142 Tbio Transcription Factor 0.05 0.69 17
Zinc finger protein 138 ZNF138 Tdark Transcription Factor 1.15 0.03 69
Zinc finger protein 135 ZNF135 Tbio Transcription Factor -2.08875 114.1 68