Development Level

Tbio 571 | 10,625
Tdark 503 | 7,003
Tchem 88 | 1,890
Tclin 8 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 45 | 633
embryonic lethality prior to t... 16 | 187
preweaning lethality, incomple... 13 | 260
decreased lean body mass 12 | 195
decreased total body fat amoun... 12 | 186
embryonic lethality prior to o... 12 | 148
abnormal behavior 9 | 226
abnormal embryo size 9 | 112
increased or absent threshold ... 9 | 128
decreased body weight 8 | 174
decreased bone mineral content 8 | 157
increased bone mineral content 8 | 92
decreased body length 7 | 108
decreased lumbar vertebrae num... 7 | 62
increased sacral vertebrae num... 7 | 62
decreased circulating total pr... 6 | 41
decreased grip strength 6 | 123
hypoactivity 6 | 89
abnormal bone structure 5 | 131
decreased circulating serum al... 5 | 79
hyperactivity 5 | 108
increased circulating alkaline... 5 | 119
increased lean body mass 5 | 107
increased startle reflex 5 | 38
increased total body fat amoun... 5 | 57
abnormal retina morphology 4 | 100
decreased bone mineral density 4 | 126
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating triglyce... 4 | 83
enlarged heart 4 | 111
hydrops fetalis 4 | 22
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
short tibia 4 | 82
small testis 4 | 37
vertebral transformation 4 | 12
abnormal eye morphology 3 | 38
abnormal forebrain development 3 | 18
abnormal gait 3 | 51
abnormal hindbrain development 3 | 24
abnormal lens morphology 3 | 73
abnormal locomotor activation 3 | 26
abnormal neural tube closure 3 | 37
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating choleste... 3 | 85
decreased circulating fructosa... 3 | 31
decreased circulating glucose ... 3 | 121
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased mean corpuscular vol... 3 | 50
decreased rib number 3 | 59
decreased threshold for audito... 3 | 32
enlarged spleen 3 | 26
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased grip strength 3 | 83
increased heart rate 3 | 17
pale yolk sac 3 | 12
prenatal lethality prior to he... 3 | 64
thrombocytopenia 3 | 46
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal heart left ventricle ... 2 | 20
abnormal iris morphology 2 | 12
abnormal limb bud morphology 2 | 15
abnormal midbrain development 2 | 22
abnormal retinal blood vessel ... 2 | 18
abnormal sacral vertebrae morp... 2 | 5
abnormal seminal vesicle morph... 2 | 47
abnormal testis morphology 2 | 30
abnormal tooth morphology 2 | 24
absent heartbeat 2 | 6
anophthalmia 2 | 20
cataract 2 | 26
corneal opacity 2 | 25
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating insulin ... 2 | 75
decreased monocyte cell number 2 | 28
impaired glucose tolerance 2 | 52
increased B cell number 2 | 23
increased body length 2 | 20
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating phosphat... 2 | 24
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
irregularly shaped pupil 2 | 7
male infertility 2 | 62
polydactyly 2 | 22
shortened RR interval 2 | 19
small adrenal glands 2 | 15
small superior vagus ganglion 2 | 20

Disease

osteosarcoma 539 | 7,933
ovarian cancer 499 | 8,484
medulloblastoma, large-cell 362 | 6,234
psoriasis 314 | 6,685
glioblastoma 313 | 5,572
atypical teratoid / rhabdoid tumor 257 | 4,369
lung cancer 255 | 4,466
primitive neuroectodermal tumor 195 | 3,031
malignant mesothelioma 180 | 3,162
group 3 medulloblastoma 174 | 2,254
Breast cancer 160 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 160 | 3,289
Carcinoma 157 | 2,147
oligodendroglioma 153 | 2,849
ependymoma 148 | 2,514
group 4 medulloblastoma 148 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 144 | 2,988
pediatric high grade glioma 140 | 2,712
Cancer 135 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 134 | 2,956
astrocytic glioma 124 | 2,241
pilocytic astrocytoma 116 | 3,086
invasive ductal carcinoma 107 | 2,950
Pick disease 105 | 1,893
adult high grade glioma 104 | 2,148
lung carcinoma 102 | 2,844
subependymal giant cell astrocytoma 94 | 2,287
interstitial cystitis 93 | 2,299
medulloblastoma 91 | 1,524
sonic hedgehog group medulloblastoma 91 | 1,482
lung adenocarcinoma 90 | 2,713
astrocytoma 87 | 1,493
non-small cell lung cancer 87 | 2,798
pituitary cancer 86 | 1,972
adrenocortical carcinoma 85 | 1,427
pancreatic cancer 84 | 2,300
spina bifida 79 | 1,064
tuberculosis 76 | 1,557
pancreatic ductal adenocarcinoma liver metastasis 75 | 1,795
Multiple myeloma 71 | 1,327
diabetes mellitus 70 | 1,663
Rheumatoid Arthritis 68 | 1,160
cystic fibrosis 68 | 1,665
juvenile dermatomyositis 66 | 1,189
acute quadriplegic myopathy 65 | 1,157
breast carcinoma 65 | 1,614
posterior fossa group A ependymoma 64 | 1,511
ulcerative colitis 63 | 2,087
colon cancer 62 | 1,475
posterior fossa group B ependymoma 60 | 1,530
tuberculosis and treatment for 6 months 60 | 686
acute myeloid leukemia 58 | 780
ductal carcinoma in situ 57 | 1,745
atypical teratoid/rhabdoid tumor 53 | 1,095
dermatomyositis 49 | 933
non primary Sjogren syndrome sicca 49 | 840
Waldenstrons macroglobulinemia 44 | 765
primary pancreatic ductal adenocarcinoma 43 | 1,271
hepatocellular carcinoma 41 | 532
Intellectual disability 38 | 573
aldosterone-producing adenoma 38 | 664
active Crohn's disease 36 | 918
cutaneous lupus erythematosus 36 | 1,056
primary Sjogren syndrome 36 | 789
gastric cancer 34 | 430
nasopharyngeal carcinoma 34 | 1,056
Mammary Neoplasms 33 | 410
progressive supranuclear palsy 33 | 674
pancreatic carcinoma 32 | 567
Alzheimer's disease 30 | 644
Amyotrophic Lateral Sclerosis 30 | 431
Prostatic Neoplasms 30 | 471
Atopic dermatitis 29 | 944
Polycystic Ovary Syndrome 29 | 332
Obesity 26 | 616
gastric carcinoma 26 | 832
active ulcerative colitis 24 | 477
inflammatory breast cancer 24 | 404
Schizophrenia 23 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
Down syndrome 21 | 548
Duchenne muscular dystrophy 21 | 602
Prostate cancer 21 | 172
Melanoma 20 | 261
Stomach Neoplasms 20 | 282
esophageal adenocarcinoma 20 | 737
glioblastoma multiforme 20 | 347
Acquired metabolic disease 19 | 267
Endometriosis 18 | 535
Colorectal Neoplasms 17 | 217
Crohn's disease 17 | 304
sarcoidosis 17 | 358
Adenoid Cystic Carcinoma 16 | 99
Multiple Sclerosis 16 | 498
Asthma 15 | 349
Gaucher disease type 1 15 | 171
hereditary spastic paraplegia 15 | 313
Peripheral Neuropathy 14 | 303
chronic lymphosyte leukemia 14 | 232
chronic rhinosinusitis 14 | 512

Tissue

Female tissues 1,125 | 18,647
Nervous System 1,123 | 18,561
Digestive Tract 1,121 | 18,473
Endocrine System 1,119 | 18,512
Male tissues 1,115 | 17,969
Urinary Tract 1,114 | 18,444
Blood and immune system 1,113 | 17,995
Liver and Pancreas 1,111 | 18,136
Skin and soft tissues 1,100 | 18,115
Cardiovascular System 1,098 | 17,958
Respiratory system 1,066 | 17,484

Target Family

Transcription Factor 621 | 1,400
Non-IDG 355 | 11,971
Enzyme 68 | 4,146
Epigenetic 64 | 242
Kinase 31 | 634
TF/Epigenetic 14 | 38
Nuclear Receptor 11 | 48
Transporter 3 | 473
GPCR 2 | 406
oGPCR 1 | 421

GO Process

regulation of transcription, D... 1,170 | 1,170
transcription, DNA-templated 1,779 | 1,779
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Transcription factor 24 TCF24 Tdark Non-IDG 0.30 0.09 0
Putative protein SSX6 SSX6 Tdark Non-IDG 0.60 0.17 0
Protein SSX8 SSX8 Tdark Non-IDG 0.00000 0
Protein SSX7 SSX7 Tdark Non-IDG 0.60 0.09 51
Protein SSX9 SSX9 Tdark Non-IDG 0.00000 0
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78