Development Level

Tbio 122 | 11,445
Tdark 15 | 6,588
Tchem 3 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 5 | 499
abnormal behavior 3 | 298
decreased body weight 3 | 161
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased total body fat amoun... 2 | 207
hypoactivity 2 | 132
increased circulating calcium ... 2 | 34
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
microphthalmia 2 | 26
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 1
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 113 | 11,493
osteosarcoma 86 | 7,950
ovarian cancer 85 | 8,520
glioblastoma 70 | 5,792
medulloblastoma, large-cell 68 | 6,241
atypical teratoid / rhabdoid tumor 60 | 5,112
psoriasis 56 | 6,694
adult high grade glioma 55 | 3,801
ependymoma 53 | 4,679
Kidney cancer 51 | 2,613
lung cancer 51 | 4,740
group 3 medulloblastoma 47 | 4,104
primitive neuroectodermal tumor 47 | 3,035
invasive ductal carcinoma 43 | 2,951
subependymal giant cell astrocytoma 43 | 2,287
non-small cell lung cancer 42 | 2,890
Astrocytoma, Pilocytic 41 | 3,081
Breast cancer 39 | 3,578
lung carcinoma 39 | 2,843
lung adenocarcinoma 36 | 2,716
oligodendroglioma 36 | 2,850
astrocytic glioma 35 | 2,597
malignant mesothelioma 34 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
group 4 medulloblastoma 31 | 1,855
Cancer 29 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
Pick disease 27 | 1,894
interstitial cystitis 27 | 2,312
ulcerative colitis 27 | 1,819
cystic fibrosis 25 | 1,696
ductal carcinoma in situ 24 | 1,745
pituitary cancer 24 | 1,972
pancreatic cancer 23 | 2,398
breast carcinoma 20 | 1,638
Intellectual disability 19 | 1,016
acute quadriplegic myopathy 17 | 1,158
colon cancer 15 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
tuberculosis 15 | 2,010
cutaneous lupus erythematosus 13 | 1,057
spina bifida 13 | 1,074
primary Sjogren syndrome 12 | 735
Liver Cirrhosis, Experimental 11 | 769
Melanoma 11 | 711
pediatric high grade glioma 11 | 1,064
Rheumatoid arthritis 10 | 1,191
Schizophrenia 10 | 1,160
gastric carcinoma 10 | 807
juvenile dermatomyositis 10 | 1,187
primary pancreatic ductal adenocarcinoma 10 | 1,109
Liver cancer 9 | 604
Waldenstrons macroglobulinemia 9 | 765
aldosterone-producing adenoma 9 | 665
astrocytoma 9 | 1,146
dermatomyositis 9 | 966
mucosa-associated lymphoid tissue lymphoma 9 | 484
Amyotrophic lateral sclerosis 8 | 451
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Multiple myeloma 8 | 1,332
Poor school performance 8 | 645
active Crohn's disease 8 | 922
active ulcerative colitis 8 | 764
adrenocortical carcinoma 8 | 1,428
fibroadenoma 8 | 559
gastric cancer 8 | 459
Endometriosis 7 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
diabetes mellitus 7 | 1,728
esophageal adenocarcinoma 7 | 737
hepatocellular carcinoma 7 | 547
nasopharyngeal carcinoma 7 | 1,058
non primary Sjogren syndrome sicca 7 | 891
Alzheimer's disease 6 | 658
Cryptorchidism 6 | 296
Endometrial cancer 6 | 311
Polycystic ovary syndrome 6 | 360
Skin cancer 6 | 469
interstitial lung disease 6 | 298
medulloblastoma 6 | 720
pancreatic carcinoma 6 | 562
progressive supranuclear palsy 6 | 676
sonic hedgehog group medulloblastoma 6 | 467
Atopic dermatitis 5 | 952
Cognitive delay 5 | 608
Epilepsy 5 | 792
Global developmental delay 5 | 608
HIV Infections 5 | 102
Mental and motor retardation 5 | 608
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Short stature 5 | 531
Strabismus 5 | 270
X- linked recessive 5 | 110
sarcoidosis 5 | 370
tuberculosis and treatment for 3 months 5 | 179

Tissue

Digestive Tract 140 | 17,369
Endocrine System 140 | 18,159
Female tissues 140 | 17,400
Liver and Pancreas 140 | 16,750
Skin and soft tissues 140 | 17,230
Blood and immune system 139 | 16,909
Male tissues 139 | 17,142
Nervous System 139 | 16,725
Respiratory system 139 | 16,393
Urinary Tract 139 | 16,678
Cardiovascular System 135 | 15,192

Target Family

Non-IDG 71 | 12,091
Enzyme 67 | 4,145
Kinase 3 | 634

GO Process

regulation of small GTPase med... 141 | 141
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho guanine nucleotide exchange factor 5 ARHGEF5 Tbio Non-IDG -0.48804 5.75 249
Beta-chimaerin CHN2 Tbio Non-IDG -1.78873 58.0 149
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.82623 8.55 107
Rho guanine nucleotide exchange factor 17 ARHGEF17 Tbio Non-IDG -1.38408 25.0 61
Rho GTPase-activating protein 6 ARHGAP6 Tbio Enzyme -0.85601 8.06 45
DEP domain-containing protein 7 DEPDC7 Tdark Non-IDG -0.44370 3.01 132
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.74771 54.3 35
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.99923 14.5 99
DEP domain-containing protein 1B DEPDC1B Tbio Non-IDG -0.81968 7.18 94