Development Level

Tbio 44 | 11,651
Tchem 11 | 1,388
Tdark 8 | 6,593
Tclin 4 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal bone structure 3 | 187
decreased hemoglobin content 3 | 68
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
abnormal lens morphology 2 | 81
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased red blood cell distr... 2 | 34
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
absent startle reflex 1 | 24
bleb 1 | 2
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating lactate ... 1 | 3
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
enlarged heart 1 | 210
enlarged kidney 1 | 14
head bobbing 1 | 5
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
sclerocornea 1 | 2
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 44 | 11,493
ovarian cancer 37 | 8,520
glioblastoma 29 | 5,792
Cancer 28 | 2,499
osteosarcoma 28 | 7,950
medulloblastoma, large-cell 27 | 6,241
psoriasis 27 | 6,694
lung cancer 24 | 4,740
atypical teratoid / rhabdoid tumor 23 | 5,112
Breast cancer 19 | 3,578
ependymoma 17 | 4,679
oligodendroglioma 17 | 2,850
group 3 medulloblastoma 16 | 4,104
malignant mesothelioma 16 | 3,232
Astrocytoma, Pilocytic 15 | 3,081
pancreatic cancer 15 | 2,398
primitive neuroectodermal tumor 15 | 3,035
adult high grade glioma 14 | 3,801
Autosomal recessive predisposition 13 | 1,442
Multiple myeloma 13 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Kidney cancer 12 | 2,613
breast carcinoma 11 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
astrocytic glioma 10 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
invasive ductal carcinoma 10 | 2,951
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
Neurodegenerative disease 9 | 414
Pick disease 9 | 1,894
diabetes mellitus 9 | 1,728
subependymal giant cell astrocytoma 9 | 2,287
Adenocarcinoma 8 | 122
Intellectual disability 8 | 1,016
Schizophrenia 8 | 1,160
astrocytoma 8 | 1,146
ductal carcinoma in situ 8 | 1,745
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
Carcinoma, Hepatocellular 7 | 228
Liver cancer 7 | 604
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Melanoma 7 | 711
Parkinson's disease 7 | 392
acute quadriplegic myopathy 7 | 1,158
pituitary cancer 7 | 1,972
Breast Neoplasms 6 | 445
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mammary Neoplasms 6 | 425
Mental and motor retardation 6 | 608
Ovarian Neoplasms 6 | 102
Squamous cell carcinoma 6 | 129
adrenocortical carcinoma 6 | 1,428
colon cancer 6 | 1,478
esophageal adenocarcinoma 6 | 737
medulloblastoma 6 | 720
nasopharyngeal carcinoma 6 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
Adenoma 5 | 167
Amyotrophic lateral sclerosis 5 | 451
Atopic dermatitis 5 | 952
Carcinoma, Squamous Cell 5 | 110
Colorectal Neoplasms 5 | 243
DOID:2627 5 | 94
Dull intelligence 5 | 645
Immune system cancer 5 | 140
Low intelligence 5 | 645
Lymphoid leukemia 5 | 160
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Mesothelioma, Malignant 5 | 105
Neuroblastoma 5 | 80
Obesity 5 | 678
Poor school performance 5 | 645
Prostatic Neoplasms 5 | 495
Short stature 5 | 531
Stomach Neoplasms 5 | 300
Vascular disease 5 | 319
active ulcerative colitis 5 | 764
dermatomyositis 5 | 966
gastric cancer 5 | 459
group 4 medulloblastoma 5 | 1,855
ovarian neoplasm 5 | 99
pediatric high grade glioma 5 | 1,064
tuberculosis 5 | 2,010
Depressive disorder 4 | 409
Down syndrome 4 | 499
Endometriosis 4 | 540
Epilepsy 4 | 792
Prostate cancer 4 | 175
Seizures 4 | 596
aldosterone-producing adenoma 4 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 66 | 18,159
Digestive Tract 64 | 17,369
Female tissues 64 | 17,400
Blood and immune system 63 | 16,909
Nervous System 63 | 16,725
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678
Liver and Pancreas 62 | 16,750
Male tissues 62 | 17,142
Respiratory system 62 | 16,393
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 20 | 4,145
Epigenetic 5 | 242
Transcription Factor 4 | 1,400
Kinase 3 | 634
GPCR 1 | 408
Transporter 1 | 473

GO Process

regulation of protein stabilit... 67 | 67
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
CDKN2A-interacting protein CDKN2AIP Tbio Non-IDG -0.74312 7.49 147
F-box only protein 4 FBXO4 Tbio Non-IDG -1.07080 11.1 225
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Dolichol phosphate-mannose biosynthesis regulatory protein DPM2 Tdark Non-IDG -0.95378 9.57 34
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
E3 ubiquitin-protein ligase CHIP STUB1 Tbio Enzyme -2.96877 926.8 351
Lysosome-associated membrane glycoprotein 2 LAMP2 Tbio Non-IDG -2.57929 343.7 905
Aspartyl/asparaginyl beta-hydroxylase ASPH Tbio Enzyme -2.70558 505.4 235
Ubiquitin carboxyl-terminal hydrolase 19 USP19 Tbio Enzyme -1.25950 22.1 126