Development Level

Tbio 10 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal placenta size 1 | 20
abnormal rib morphology 1 | 10
convulsive seizures 1 | 13
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hypoactivity 1 | 132
pallor 1 | 34

Disease

Carcinoma 15 | 11,493
ovarian cancer 11 | 8,520
Cancer 10 | 2,499
glioblastoma 10 | 5,792
osteosarcoma 10 | 7,950
adult high grade glioma 9 | 3,801
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
psoriasis 7 | 6,694
Breast cancer 6 | 3,578
tuberculosis 6 | 2,010
Kidney cancer 5 | 2,613
invasive ductal carcinoma 5 | 2,951
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
primitive neuroectodermal tumor 5 | 3,035
Osteoporosis 4 | 363
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Hypertensive disease 3 | 292
Increase in blood pressure 3 | 119
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
pancreatic cancer 3 | 2,398
Amyotrophic lateral sclerosis 2 | 451
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Bladder Neoplasm 2 | 112
Brachydactyly 2 | 156
Cardiomegaly 2 | 116
Cleft Palate 2 | 271
Cocaine-Related Disorders 2 | 92
Colorectal Neoplasms 2 | 243
Coronary artery disease 2 | 268
Depressive disorder 2 | 409
Familial primary pulmonary hypertension 2 | 11
Impaired left ventricular function 2 | 16
Intellectual disability 2 | 1,016
Left-Sided Heart Failure 2 | 16
Linear atrophy 2 | 15
Mental Depression 2 | 333
Obesity 2 | 678
Peripheral T-cell lymphoma 2 | 25
Primary cutaneous T-cell lymphoma 2 | 29
Rheumatoid arthritis 2 | 1,191
Short stature 2 | 531
Skin Neoplasms 2 | 69
Skin cancer 2 | 469
Urinary Bladder Neoplasms 2 | 114
chronic lymphosyte leukemia 2 | 204
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Abnormality of the iris 1 | 14
Adrenal hyperplasia 1 | 13
Aneurysm, Dissecting 1 | 8
Aortic aneurysm, familial thoracic 3 1 | 13
Ascending aortic dissection 1 | 13
Blastic phase chronic myeloid leukemia 1 | 58
Bowed and upward slanting eyebrows 1 | 41
Carney complex 1 | 25
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Cleft uvula 1 | 27
Cutis marmorata 1 | 32
Cystic medial necrosis of aorta 1 | 13
Descending aortic dissection 1 | 13
Dissection of aorta 1 | 9
Downturned corners of mouth 1 | 48
Dyspnea on exertion 1 | 24
Dyspnea, Paroxysmal 1 | 13
Familial thoracic aortic aneurysm and aortic dissection 1 | 13
Fibrolamellar hepatocellular carcinoma 1 | 2
Idiopathic pulmonary fibrosis 1 | 23
Loeys-Dietz Aortic Aneurysm Syndrome 1 | 13
Loeys-Dietz syndrome 1 | 23
Noonan syndrome 1 | 34
Papule 1 | 43
Thick, flared eyebrows 1 | 41
Thin hypoplastic alae nasi 1 | 51
Ureteral obstruction 1 | 33
Waardenburg's syndrome 1 | 17

Tissue

Endocrine System 19 | 18,159
Nervous System 19 | 16,725
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Blood and immune system 17 | 16,909

Target Family

Non-IDG 8 | 12,091
Kinase 5 | 634
Epigenetic 4 | 242
Enzyme 1 | 4,145
Transcription Factor 1 | 1,400

GO Process

regulation of protein binding 19 | 19
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856
Histone deacetylase 4 HDAC4 Tclin Epigenetic -2.42231 255.5 825
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520
Adapter molecule crk CRK Tbio Non-IDG -2.55195 357.0 432
Paired box protein Pax-7 PAX7 Tbio Transcription Factor -2.70703 468.7 418
Angiopoietin-1 ANGPT1 Tbio Non-IDG -2.85203 755.4 416
TGF-beta receptor type-1 TGFBR1 Tchem Kinase -2.94747 847.9 413
Low density lipoprotein receptor adapter protein 1 LDLRAP1 Tbio Non-IDG -2.44381 269.9 357
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331