Development Level

Tbio 11 | 11,651
Tchem 7 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
decreased leukocyte cell numbe... 1 | 73
decreased red blood cell distr... 1 | 41
edema 1 | 59
embryonic growth retardation 1 | 106
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
osteosarcoma 13 | 7,950
glioblastoma 12 | 5,792
medulloblastoma, large-cell 12 | 6,241
atypical teratoid / rhabdoid tumor 11 | 5,112
ovarian cancer 10 | 8,520
adult high grade glioma 9 | 3,801
ependymoma 8 | 4,679
interstitial cystitis 8 | 2,312
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung cancer 7 | 4,740
oligodendroglioma 7 | 2,850
psoriasis 7 | 6,694
Astrocytoma, Pilocytic 6 | 3,081
Cancer 6 | 2,499
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung carcinoma 6 | 2,843
malignant mesothelioma 6 | 3,232
primitive neuroectodermal tumor 6 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Bipolar Disorder 4 | 666
Breast cancer 4 | 3,578
Lung Neoplasms 4 | 232
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
tuberculosis 4 | 2,010
Carcinoma, Squamous Cell 3 | 110
Head and Neck Neoplasms 3 | 26
Kidney cancer 3 | 2,613
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Ovarian Neoplasms 3 | 102
Rheumatoid arthritis 3 | 1,191
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
active Crohn's disease 3 | 922
chronic rhinosinusitis 3 | 512
cystic fibrosis 3 | 1,696
ovarian neoplasm 3 | 99
primary Sjogren syndrome 3 | 735
subependymal giant cell astrocytoma 3 | 2,287
Adenocarcinoma 2 | 122
Amyotrophic lateral sclerosis 2 | 451
Arthritis 2 | 290
Autistic Disorder 2 | 364
Autosomal recessive predisposition 2 | 1,442
Brain Ischemia 2 | 110
CEROID LIPOFUSCINOSIS, NEURONAL, 6 2 | 6
Carcinoma of thyroid 2 | 17
Cardiomyopathies 2 | 110
Cholestasis, Extrahepatic 2 | 25
Cocaine-Related Disorders 2 | 92
Disease Models, Animal 2 | 155
Endometriosis 2 | 540
Female infertility 2 | 30
Gastrointestinal system disease 2 | 54
Gliosis 2 | 56
Hyperalgesia 2 | 83
Hypertensive disease 2 | 292
Hypertrophy 2 | 17
Infertility, Female 2 | 28
Kidney Neoplasm 2 | 29
Kidney Neoplasms 2 | 37
Kidney disease 2 | 430
Liver Neoplasms, Experimental 2 | 59
Lung disease 2 | 142
Melanoma 2 | 711
Nerve Degeneration 2 | 121
Pneumonia, Pneumococcal 2 | 6
Prostatic Neoplasms 2 | 495
Radiation Injuries, Experimental 2 | 11
Sepsis 2 | 24
Streptococcal pneumonia 2 | 6
Substance Withdrawal Syndrome 2 | 55
Trigeminal Neuralgia 2 | 24
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
mucosa-associated lymphoid tissue lymphoma 2 | 484
sarcoidosis 2 | 370
spina bifida 2 | 1,074

Tissue

Blood and immune system 19 | 16,909
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678
Cardiovascular System 18 | 15,192

Target Family

Kinase 9 | 634
Enzyme 5 | 4,145
Non-IDG 5 | 12,091

GO Process

regulation of phosphatidylinos... 19 | 19
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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