Development Level

Tbio 6 | 11,445
Tchem 3 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
anophthalmia 1 | 33
brachydactyly 1 | 19
cataract 1 | 92
decreased circulating alanine ... 1 | 47
decreased heart left ventricle... 1 | 28
increased circulating alanine ... 1 | 13
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

ovarian cancer 7 | 8,520
Carcinoma 6 | 11,493
medulloblastoma, large-cell 6 | 6,241
adrenocortical carcinoma 5 | 1,428
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
lung adenocarcinoma 5 | 2,716
non-small cell lung cancer 5 | 2,890
Breast cancer 4 | 3,578
Cancer 4 | 2,499
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
psoriasis 4 | 6,694
Atopic dermatitis 3 | 952
Endometriosis 3 | 540
Kidney cancer 3 | 2,613
adult high grade glioma 3 | 3,801
ependymoma 3 | 4,679
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
primitive neuroectodermal tumor 3 | 3,035
Autosomal recessive predisposition 2 | 1,442
Delayed bone age 2 | 136
Fetal Growth Retardation 2 | 189
Hypoplastic mandible condyle 2 | 275
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Seckel syndrome 2 | 34
Small head 2 | 374
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
Acquired metabolic disease 1 | 336
Bilateral fifth finger clinodactyly 1 | 110
Breast Neoplasms 1 | 445
Cachexia 1 | 50
Congenital small ears 1 | 48
Cortical gyral simplification 1 | 19
Craniosynostosis 1 | 74
Curvature of little finger 1 | 110
Decreased projection of maxilla 1 | 66
Deficiency of upper jaw bones 1 | 66
Downward slant of palpebral fissure 1 | 158
Endometrial cancer 1 | 311
Epilepsy 1 | 792
Failure to gain weight 1 | 365
Gastroesophageal reflux disease 1 | 110
Glioma 1 | 74
Heartburn 1 | 78
Hip Dislocation, Congenital 1 | 48
Hyperplasia of nose 1 | 23
Hypertrophy of nose 1 | 23
Hypoplasia of the maxilla 1 | 66
Hypoplastic feet 1 | 66
Hypotrophic maxilla 1 | 66
Impaired cognition 1 | 96
Imperforate anus 1 | 25
Joint hyperflexibility 1 | 78
Large nose 1 | 23
Leukemia 1 | 104
Liver Cirrhosis, Experimental 1 | 769
Long philtrum 1 | 137
Mammary Neoplasms 1 | 425
Maxillary retrognathia 1 | 66
Meier-Gorlin syndrome 1 | 10
Melanoma 1 | 711
Mental impairment 1 | 95
Microcephaly 1 | 166
Motor delay 1 | 147
Neuronal ceroid lipofuscinosis 1 | 28
Neutropenia 1 | 72
No development of motor milestones 1 | 147
Patellar aplasia 1 | 8
Pediatric failure to thrive 1 | 365
Polycystic ovary syndrome 1 | 360
Retrusion of upper jaw bones 1 | 66
Round face 1 | 45
Round, full face 1 | 45
Seizures 1 | 596
Skin cancer 1 | 469
Skull malformation 1 | 38
Slender, gracile long tubular bones 1 | 21
Testicular cancer 1 | 25
Triangular face 1 | 58
Varicocele 1 | 26
active Crohn's disease 1 | 922
colon cancer 1 | 1,478
pediatric high grade glioma 1 | 1,064
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 4 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

GO Process

regulation of mitotic metaphas... 9 | 9
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Ubiquitin-conjugating enzyme E2 C UBE2C Tbio Non-IDG -1.93680 92.1 352
Centromere-associated protein E CENPE Tchem Non-IDG -2.14817 140.2 166
E3 ubiquitin-protein ligase HECW2 HECW2 Tbio Enzyme -0.88176 7.59 142
Serine/threonine-protein kinase Nek6 NEK6 Tchem Kinase -1.53724 36.6 188
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856
Cell division control protein 6 homolog CDC6 Tbio Non-IDG -2.51683 336.8 574
Anaphase-promoting complex subunit CDC26 CDC26 Tbio Enzyme -0.79588 4.56 54