Development Level

Tbio 7 | 11,445
Tchem 1 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased circulating glucose ... 2 | 126
abnormal retina morphology 1 | 71
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
preweaning lethality, complete... 1 | 979
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 7 | 11,493
Cockayne syndrome 4 | 60
Xeroderma pigmentosum 4 | 43
Arthralgia 3 | 90
Atrophic condition of skin 3 | 25
Autosomal recessive predisposition 3 | 1,442
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Cancer 3 | 2,499
Cataract 3 | 297
Conjunctival telangiectasis 3 | 14
Cryptorchidism 3 | 296
Dental abnormalities 3 | 60
Developmental regression 3 | 95
Dry skin 3 | 75
Electroencephalogram abnormal 3 | 101
Erythema 3 | 58
Failure to gain weight 3 | 365
Fatigue 3 | 182
Fever 3 | 138
Flushing 3 | 60
Freckles 3 | 33
Hyperkeratosis 3 | 50
Hyperpigmented macules 3 | 42
Hypogonadism 3 | 173
Impaired cognition 3 | 96
Keratitis 3 | 62
Lens Opacities 3 | 231
Loss of developmental milestones 3 | 95
Melanoma 3 | 711
Mental deterioration in childhood 3 | 95
Mental impairment 3 | 95
Neurodevelopmental regression 3 | 95
Optic Atrophy 3 | 242
Papilloma 3 | 44
Pediatric failure to thrive 3 | 365
Photosensitivity of skin 3 | 51
Poikiloderma 3 | 14
Progressive mental retardation 3 | 37
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Sensorineural Hearing Loss (disorder) 3 | 284
Squamous cell carcinoma of skin 3 | 11
Strabismus 3 | 270
Telangiectasia of the skin 3 | 39
Thin skin 3 | 47
Tooth Abnormalities 3 | 69
Xerosis 3 | 75
hypopigmented skin patch 3 | 59
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
psoriasis 3 | 6,694
Abnormally small eyeball 2 | 97
Arteriosclerosis 2 | 11
Brittle hair 2 | 25
Cachexia 2 | 50
Carcinoma, Squamous Cell 2 | 110
Cerebellar Ataxia 2 | 304
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital deafness 2 | 185
Conjunctivitis 2 | 53
Conjunctivitis, recurrent 2 | 37
Deafness 2 | 198
Decreased size of eyeball 2 | 97
Defective DNA repair after ultraviolet radiation damage 2 | 7
Disease Progression 2 | 136
Dull intelligence 2 | 645
Ectropion 2 | 38
Entropion 2 | 22
Fractured hair 2 | 25
Fragile hair 2 | 25
Hardened artery wall 2 | 6
Hearing Loss, Partial 2 | 185
Hydrocephalus 2 | 152
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Microphthalmos 2 | 100
Muscle Spasticity 2 | 195
Numerous pigmented freckles 2 | 4
Peripheral demyelinating neuropathy 2 | 7
Photodysphoria 2 | 121
Photophobia 2 | 121
Photosensitive trichothiodystrophy 2 | 30
Poor school performance 2 | 645
Precociously senile appearance 2 | 18
Reduced tensile strength of hair 2 | 25
Retinal Diseases 2 | 55
Short stature 2 | 531
Small head 2 | 374
Spider Veins 2 | 17
Stomach Neoplasms 2 | 300
Telangiectasis 2 | 36
Xeroderma pigmentosum-Cockayne syndrome complex 2 | 4
hearing impairment 2 | 199
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 3 | 12,091
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Process

regulation of mitotic cell cyc... 8 | 8
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATPase family AAA domain-containing protein 5 ATAD5 Tbio Enzyme -1.60534 42.9 117
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
DNA damage-binding protein 1 DDB1 Tbio Non-IDG -2.34719 202.5 353
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.21142 154.0 208
Serine/threonine-protein kinase Nek11 NEK11 Tchem Kinase -0.69544 5.52 155
Ubiquitin D UBD Tbio Non-IDG -2.35231 223.1 210
TFIIH basal transcription factor complex helicase XPB subunit ERCC3 Tbio Enzyme -1.96419 91.4 163