Development Level

Tchem 48 | 1,388
Tbio 28 | 11,651
Tdark 4 | 6,593
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 11 | 125
RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal bone structure 4 | 187
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 3 | 499
abnormal pelvic girdle bone mo... 2 | 12
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vertebrae morphology 1 | 18
abnormal zygomatic bone morpho... 1 | 3
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased urine microalbumin l... 1 | 2
long tibia 1 | 25
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 66 | 11,493
ovarian cancer 54 | 8,520
osteosarcoma 46 | 7,950
psoriasis 35 | 6,694
medulloblastoma, large-cell 34 | 6,241
lung cancer 33 | 4,740
Cancer 29 | 2,499
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 26 | 5,112
malignant mesothelioma 26 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
ependymoma 22 | 4,679
Breast cancer 20 | 3,578
group 3 medulloblastoma 20 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Kidney cancer 19 | 2,613
non-small cell lung cancer 19 | 2,890
pancreatic cancer 19 | 2,398
primitive neuroectodermal tumor 19 | 3,035
oligodendroglioma 18 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
adult high grade glioma 15 | 3,801
astrocytic glioma 15 | 2,597
lung carcinoma 14 | 2,843
Astrocytoma, Pilocytic 13 | 3,081
Blastic phase chronic myeloid leukemia 13 | 58
Chronic Myelocytic Leukemia Accelerated Phase 13 | 59
subependymal giant cell astrocytoma 13 | 2,287
invasive ductal carcinoma 12 | 2,951
Pick disease 11 | 1,894
cystic fibrosis 11 | 1,696
dermatomyositis 11 | 966
Renal Cell Carcinoma 10 | 214
adrenocortical carcinoma 10 | 1,428
interstitial cystitis 10 | 2,312
tuberculosis 10 | 2,010
Intellectual disability 9 | 1,016
Multiple myeloma 9 | 1,332
Rheumatoid arthritis 9 | 1,191
group 4 medulloblastoma 9 | 1,855
Breast Neoplasms 8 | 445
Epilepsy 8 | 792
Gastrointestinal stromal tumor 8 | 62
HER2-positive carcinoma of breast 8 | 21
Pancreatic Neuroendocrine Tumor 8 | 45
acute quadriplegic myopathy 8 | 1,158
breast carcinoma 8 | 1,638
diabetes mellitus 8 | 1,728
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
primary pancreatic ductal adenocarcinoma 8 | 1,109
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mammary Neoplasms 7 | 425
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
juvenile dermatomyositis 7 | 1,187
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074
Atopic dermatitis 6 | 952
Endometriosis 6 | 540
Lung Neoplasms 6 | 232
Muscle hypotonia 6 | 571
Waldenstrons macroglobulinemia 6 | 765
astrocytoma 6 | 1,146
ductal carcinoma in situ 6 | 1,745
medulloblastoma 6 | 720
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Congenital Epicanthus 5 | 177
Downward slant of palpebral fissure 5 | 158
Hemangioma 5 | 69
Schizophrenia 5 | 1,160
Seizures 5 | 596
Short nose 5 | 132
Small nose 5 | 132
acute myeloid leukemia 5 | 783
colon cancer 5 | 1,478
nasopharyngeal carcinoma 5 | 1,058
pancreatic carcinoma 5 | 562
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Curvature of spine 4 | 282
Large auricle 4 | 87
Large protruding ears 4 | 87
Large, floppy ears 4 | 87
Liver Cirrhosis, Experimental 4 | 769
Long philtrum 4 | 137
Macrotia 4 | 87
Orbital separation excessive 4 | 244
Parkinson's disease 4 | 392
Short neck 4 | 140
Skin cancer 4 | 469
Strabismus 4 | 270
atypical teratoid/rhabdoid tumor 4 | 357
cutaneous lupus erythematosus 4 | 1,057
pediatric high grade glioma 4 | 1,064
posterior fossa group B ependymoma 4 | 416
progressive supranuclear palsy 4 | 676
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 80 | 18,159
Digestive Tract 79 | 17,369
Female tissues 79 | 17,400
Male tissues 78 | 17,142
Liver and Pancreas 77 | 16,750
Nervous System 77 | 16,725
Respiratory system 77 | 16,393
Skin and soft tissues 77 | 17,230
Urinary Tract 76 | 16,678
Blood and immune system 75 | 16,909
Cardiovascular System 75 | 15,192

Target Family

Kinase 56 | 634
Non-IDG 17 | 12,091
Transcription Factor 5 | 1,400
Enzyme 3 | 4,145
Epigenetic 1 | 242

GO Process

regulation of mitotic cell cyc... 82 | 82
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Protein AATF AATF Tbio Non-IDG -2.20561 160.5 230
F-box only protein 5 FBXO5 Tbio Non-IDG -1.71993 56.0 137
THAP domain-containing protein 1 THAP1 Tbio Transcription Factor -1.99752 104.3 67
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
Mitogen-activated protein kinase kinase kinase 3 MAP3K3 Tchem Kinase -1.73612 54.7 183
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Cyclin-dependent kinase 19 CDK19 Tchem Kinase -1.35400 18.0 154
Mitogen-activated protein kinase kinase kinase kinase 3 MAP4K3 Tchem Kinase -1.15845 15.3 254