Development Level

Tbio 13 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal vitreous body morphol... 1 | 10
decreased circulating glucose ... 1 | 126
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 8 | 11,493
ovarian cancer 6 | 8,520
Neurodegenerative disease 5 | 414
Parkinson's disease 5 | 392
Nerve Degeneration 4 | 121
Parkinson Disease 4 | 64
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
Dementia 3 | 175
Hyperreflexia 3 | 209
Optic Atrophy 3 | 242
Parkinsonian Disorders 3 | 56
Schizophrenia 3 | 1,160
adult high grade glioma 3 | 3,801
lung cancer 3 | 4,740
osteosarcoma 3 | 7,950
psoriasis 3 | 6,694
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Autosomal recessive predisposition 2 | 1,442
Cancer 2 | 2,499
Enophthalmos 2 | 75
Huntington's disease 2 | 76
Major Depressive Disorder 2 | 301
Manganese Poisoning 2 | 11
Movement disease 2 | 11
Multiple myeloma 2 | 1,332
Muscle Rigidity 2 | 49
Muscle Spasticity 2 | 195
PARKINSON DISEASE 19, JUVENILE-ONSET 2 | 10
Paraparesis 2 | 6
Physical aggression 2 | 76
Postural instability 2 | 19
Rheumatoid arthritis 2 | 1,191
Secondary Parkinson Disease 2 | 10
Young onset Parkinson disease 2 | 10
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
invasive ductal carcinoma 2 | 2,951
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
Abnormal brain FDG positron emission tomography 1 | 9
Abnormal lower motor neuron morphology 1 | 6
Autosomal dominant late onset Parkinson disease 1 | 7
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 1 | 13
Behavioral variant of frontotemporal dementia 1 | 8
Bronchioloalveolar Adenocarcinoma 1 | 14
Cervical Dystonia 1 | 26
Collapse of vertebra 1 | 14
Compression fracture of vertebral column 1 | 14
Compulsive hoarding 1 | 7
Cranial nerve palsies 1 | 11
Developmental arithmetic disorder 1 | 8
Dysphasia 1 | 23
EMG positive sharp waves 1 | 2
EMG: myopathic abnormalities 1 | 22
EMG: myotonic discharges 1 | 2
Echolalia 1 | 12
Excess nuchal skin 1 | 30
Fatigable weakness of respiratory muscles 1 | 28
Fatigable weakness of swallowing muscles 1 | 28
Fatty replacement of skeletal muscle 1 | 3
Foot dorsiflexor weakness 1 | 27
Foot-drop 1 | 27
Frontotemporal cerebral atrophy 1 | 8
Gait, Drop Foot 1 | 24
Hyperorality 1 | 7
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia 1 | 13
Irritation - emotion 1 | 68
Leprosy 1 | 73
Leri-Weill dyschondrosteosis 1 | 7
Limited shoulder movement 1 | 3
Limited wrist extension 1 | 2
Long bone fractures 1 | 2
Long tract signs 1 | 3
Memory Disorders 1 | 40
Mutism 1 | 17
NONAKA MYOPATHY 1 | 2
Neurodegeneration with brain iron accumulation 1 | 20
PARKINSON DISEASE 17 1 | 1
Posterior fossa compression syndrome 1 | 2
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Reflex, Ankle, Absent 1 | 8
Restlessness 1 | 14
Restrictive behavior 1 | 7
Restrictive behavior, interests, and activities 1 | 7
Rimmed vacuoles on biopsy 1 | 15
Shoulder girdle weakness 1 | 10
Shoulder weakness 1 | 10
Spasmodic torticollis 1 | 17
Supranuclear gaze palsy 1 | 6
Torticollis 1 | 18
Variation in muscle fiber size 1 | 16
Weakness of hip flexors 1 | 2
Xerostomia 1 | 42

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634
Transporter 1 | 473

GO Process

regulation of mitochondrion or... 13 | 13
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vacuolar protein sorting-associated protein 35 VPS35 Tbio Non-IDG -2.02621 104.1 124
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
Serine/threonine-protein kinase PINK1, mitochondrial PINK1 Tbio Kinase -2.81574 706.5 546
Mitochondrial fission 1 protein FIS1 Tbio Non-IDG -2.19572 143.4 224
Golgi phosphoprotein 3 GOLPH3 Tbio Non-IDG -3.64962 4208.3 168
Storkhead-box protein 1 STOX1 Tbio Non-IDG -1.28985 20.3 45
Presenilins-associated rhomboid-like protein, mitochondrial PARL Tbio Enzyme -1.50388 31.7 100
Mitochondrial fission factor MFF Tbio Non-IDG -2.26188 175.4 119
Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 Tbio Enzyme -2.41710 245.8 150
Dynamin-1-like protein DNM1L Tbio Non-IDG -2.65717 476.9 426