Development Level

Tbio 29 | 11,445
Tclin 26 | 613
Tchem 10 | 1,598
Tdark 3 | 6,588

Collection

Ion Channel: IDG Consortium (T... 7 | 99

IMPC Phenotype

impaired glucose tolerance 3 | 75
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
enlarged spleen 2 | 41
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal joint morphology 1 | 23
abnormal limb bud morphology 1 | 17
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hypoactivity 1 | 132
increased circulating serum al... 1 | 22
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

Carcinoma 61 | 11,493
psoriasis 34 | 6,694
ependymoma 30 | 4,679
medulloblastoma, large-cell 29 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
Kidney cancer 25 | 2,613
glioblastoma 25 | 5,792
Astrocytoma, Pilocytic 23 | 3,081
osteosarcoma 23 | 7,950
group 3 medulloblastoma 21 | 4,104
ovarian cancer 21 | 8,520
adult high grade glioma 20 | 3,801
primitive neuroectodermal tumor 20 | 3,035
lung cancer 19 | 4,740
oligodendroglioma 18 | 2,850
lung carcinoma 17 | 2,843
Schizophrenia 16 | 1,160
Autosomal recessive predisposition 14 | 1,442
astrocytic glioma 14 | 2,597
Multiple Sclerosis 12 | 540
Breast cancer 11 | 3,578
Epilepsy 11 | 792
cystic fibrosis 11 | 1,696
malignant mesothelioma 11 | 3,232
subependymal giant cell astrocytoma 11 | 2,287
Eaton-Lambert syndrome 10 | 40
Pendred Syndrome 10 | 22
Pick disease 10 | 1,894
Diastrophic dysplasia 9 | 21
pituitary cancer 9 | 1,972
colon cancer 8 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung adenocarcinoma 8 | 2,716
ulcerative colitis 8 | 1,819
Atrial Fibrillation 7 | 124
Intellectual disability 7 | 1,016
Seizures 7 | 596
group 4 medulloblastoma 7 | 1,855
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Liver cancer 6 | 604
Melanoma 6 | 711
Nonsyndromic deafness 6 | 142
astrocytoma 6 | 1,146
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
Abnormality of retinal pigmentation 5 | 111
Autistic Disorder 5 | 364
Difficulties with night vision 5 | 87
Dull intelligence 5 | 645
Endometriosis 5 | 540
Hypertension 5 | 396
Long QT syndrome 5 | 39
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Night Blindness 5 | 101
Paroxysmal atrial fibrillation 5 | 14
Photodysphoria 5 | 121
Photophobia 5 | 121
Poor school performance 5 | 645
Retinal pigment epithelial abnormality 5 | 111
Skin cancer 5 | 469
acute quadriplegic myopathy 5 | 1,158
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
Alcoholic Intoxication, Chronic 4 | 289
Angina Pectoris 4 | 32
Anteverted nostril 4 | 191
Bipolar Disorder 4 | 666
Cancer 4 | 2,499
Cataract 4 | 297
Chronic heart failure 4 | 46
Chronic obstructive pulmonary disease 4 | 184
Cleft Palate 4 | 271
Cognitive delay 4 | 608
Electroretinogram abnormal 4 | 95
Feeding difficulties 4 | 127
General anesthesia 4 | 53
Global developmental delay 4 | 608
Hypertensive disorder 4 | 56
Lens Opacities 4 | 231
Liddle syndrome 4 | 14
Mental Depression 4 | 333
Mental and motor retardation 4 | 608
Nicotine dependence 4 | 54
Obesity 4 | 678
Ophthalmoplegia 4 | 106
Psychotic Disorders 4 | 151
Retinitis Pigmentosa 4 | 226
Vascular disease 4 | 319
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
non primary Sjogren syndrome sicca 4 | 891
sonic hedgehog group medulloblastoma 4 | 467
Glaucoma 3 | 239
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074

Tissue

Endocrine System 68 | 18,159
Nervous System 64 | 16,725
Female tissues 63 | 17,400
Digestive Tract 62 | 17,369
Male tissues 62 | 17,142
Skin and soft tissues 62 | 17,230
Liver and Pancreas 61 | 16,750
Urinary Tract 60 | 16,678
Blood and immune system 56 | 16,909
Respiratory system 56 | 16,393
Cardiovascular System 47 | 15,192

Target Family

Ion Channel 37 | 344
Non-IDG 12 | 12,091
Transporter 12 | 473
Enzyme 5 | 4,145
GPCR 1 | 408
Kinase 1 | 634

GO Process

regulation of membrane potenti... 68 | 68
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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