Development Level

Tbio 59 | 11,445
Tchem 17 | 1,598
Tclin 8 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal eye morphology 3 | 68
abnormal lens morphology 3 | 81
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
enlarged heart 3 | 210
increased startle reflex 3 | 112
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating phosphat... 2 | 26
increased red blood cell distr... 2 | 34
abnormal behavioral response t... 1 | 66
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal hair growth 1 | 10
abnormal iris morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal pupil morphology 1 | 2
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
absent optic nerve 1 | 2
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac output 1 | 3
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased total retina thickne... 1 | 4
increased vertical activity 1 | 24
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Carcinoma 67 | 11,493
ovarian cancer 53 | 8,520
psoriasis 53 | 6,694
osteosarcoma 39 | 7,950
malignant mesothelioma 34 | 3,232
medulloblastoma, large-cell 32 | 6,241
Cancer 28 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Obesity 26 | 678
diabetes mellitus 26 | 1,728
glioblastoma 26 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
lung cancer 25 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Breast cancer 23 | 3,578
invasive ductal carcinoma 23 | 2,951
atypical teratoid / rhabdoid tumor 22 | 5,112
group 3 medulloblastoma 22 | 4,104
ductal carcinoma in situ 21 | 1,745
Kidney cancer 20 | 2,613
interstitial cystitis 17 | 2,312
non-small cell lung cancer 17 | 2,890
Pick disease 16 | 1,894
pancreatic cancer 16 | 2,398
tuberculosis 16 | 2,010
breast carcinoma 15 | 1,638
cystic fibrosis 15 | 1,696
lung carcinoma 15 | 2,843
oligodendroglioma 15 | 2,850
pituitary cancer 15 | 1,972
Liver Cirrhosis, Experimental 14 | 769
adrenocortical carcinoma 14 | 1,428
adult high grade glioma 14 | 3,801
ependymoma 14 | 4,679
primitive neuroectodermal tumor 14 | 3,035
Rheumatoid arthritis 13 | 1,191
acute quadriplegic myopathy 13 | 1,158
lung adenocarcinoma 13 | 2,716
subependymal giant cell astrocytoma 13 | 2,287
active ulcerative colitis 12 | 764
astrocytic glioma 12 | 2,597
astrocytoma 12 | 1,146
colon cancer 12 | 1,478
Atherosclerosis 11 | 291
Fatty liver disease 11 | 103
Hepatomegaly 11 | 285
Lipid metabolism disorder 11 | 114
ulcerative colitis 11 | 1,819
Astrocytoma, Pilocytic 10 | 3,081
Atopic dermatitis 10 | 952
Autosomal recessive predisposition 10 | 1,442
Multiple myeloma 10 | 1,332
Prostatic Neoplasms 10 | 495
Seizures 10 | 596
active Crohn's disease 10 | 922
juvenile dermatomyositis 10 | 1,187
Carcinoma, Hepatocellular 9 | 228
Coronary artery disease 9 | 268
Epilepsy 9 | 792
Liver carcinoma 9 | 240
Heart disease 8 | 306
Liver disease 8 | 237
aldosterone-producing adenoma 8 | 665
cutaneous lupus erythematosus 8 | 1,057
esophageal adenocarcinoma 8 | 737
non primary Sjogren syndrome sicca 8 | 891
spina bifida 8 | 1,074
Bipolar Disorder 7 | 666
Breast Neoplasms 7 | 445
Diabetes Mellitus, Experimental 7 | 108
Endometriosis 7 | 540
Hypertension 7 | 396
Hypertensive disease 7 | 292
Mammary Neoplasms 7 | 425
Muscle hypotonia 7 | 571
Polycystic ovary syndrome 7 | 360
Schizophrenia 7 | 1,160
Waldenstrons macroglobulinemia 7 | 765
dermatomyositis 7 | 966
mucosa-associated lymphoid tissue lymphoma 7 | 484
Cardiomegaly 6 | 116
Chemical and Drug Induced Liver Injury 6 | 195
Elevated hepatic transaminases 6 | 81
Hepatic enzyme increased 6 | 81
Hypoglycemia 6 | 152
Intellectual disability 6 | 1,016
Kidney Failure, Chronic 6 | 46
Liver Dysfunction 6 | 99
Liver enzymes abnormal 6 | 81
Liver function test increased 6 | 81
Liver function tests abnormal finding 6 | 81
Subclinical abnormal liver function tests 6 | 81
Transaminases increased 6 | 81
fibroadenoma 6 | 559
gastric carcinoma 6 | 807
nasopharyngeal carcinoma 6 | 1,058
pancreatic carcinoma 6 | 562
primary pancreatic ductal adenocarcinoma 6 | 1,109
Mental Depression 5 | 333

Tissue

Digestive Tract 86 | 17,369
Endocrine System 86 | 18,159
Skin and soft tissues 86 | 17,230
Female tissues 85 | 17,400
Liver and Pancreas 85 | 16,750
Male tissues 85 | 17,142
Nervous System 83 | 16,725
Blood and immune system 82 | 16,909
Respiratory system 82 | 16,393
Urinary Tract 82 | 16,678
Cardiovascular System 76 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 22 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 5 | 242
Nuclear Receptor 5 | 48
Transporter 3 | 473
Kinase 2 | 634
GPCR 1 | 408

GO Process

regulation of lipid metabolic ... 87 | 87
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DnaJ homolog subfamily C member 15 DNAJC15 Tbio Non-IDG -1.67016 50.2 31
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Serine/threonine-protein phosphatase 4 regulatory subunit 3B PPP4R3B Tbio Enzyme -1.46618 28.8 121
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Alpha-1-antichymotrypsin SERPINA3 Tbio Non-IDG -2.94780 812.7 276
T-lymphoma invasion and metastasis-inducing protein 2 TIAM2 Tbio Non-IDG -1.27322 19.7 151
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30
5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 Tbio Enzyme -1.80580 61.7 153