Development Level

Tbio 24 | 11,445
Tchem 8 | 1,598
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased circulating insulin ... 1 | 76
decreased grip strength 1 | 116
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
increased fasted circulating g... 1 | 76
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 25 | 8,520
Carcinoma 19 | 11,493
glioblastoma 17 | 5,792
medulloblastoma, large-cell 17 | 6,241
Cancer 16 | 2,499
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
Breast cancer 15 | 3,578
lung cancer 15 | 4,740
atypical teratoid / rhabdoid tumor 14 | 5,112
malignant mesothelioma 12 | 3,232
non-small cell lung cancer 12 | 2,890
group 3 medulloblastoma 11 | 4,104
pancreatic cancer 11 | 2,398
adult high grade glioma 10 | 3,801
Astrocytoma, Pilocytic 9 | 3,081
lung adenocarcinoma 9 | 2,716
oligodendroglioma 9 | 2,850
primary pancreatic ductal adenocarcinoma 9 | 1,109
ductal carcinoma in situ 8 | 1,745
adrenocortical carcinoma 7 | 1,428
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
juvenile dermatomyositis 7 | 1,187
subependymal giant cell astrocytoma 7 | 2,287
Endometriosis 6 | 540
acute quadriplegic myopathy 6 | 1,158
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pediatric high grade glioma 6 | 1,064
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Diarrhea 5 | 253
Subcutaneous lipomas 5 | 9
Thyroid Gland Follicular Adenoma 5 | 9
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
Abdominal pain, episodic 4 | 9
Acromegaly 4 | 51
Adrenal cortical adenoma 4 | 19
Angiofibroma 4 | 7
Ataxia telangiectasia 4 | 34
Esophagitis 4 | 35
Growth hormone excess 4 | 14
Hypercalcemia 4 | 59
Hyperinsulinaemic hypoglycaemia 4 | 16
Hyperinsulinemia, fasting 4 | 7
Hyperparathyroidism 4 | 48
Increased serum parathyroid hormone 4 | 14
Insulinoma 4 | 24
Kidney cancer 4 | 2,613
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Melanoma 4 | 711
Multiple Endocrine Neoplasia Type 1 4 | 29
Multiple myeloma 4 | 1,332
Non-Functioning Pituitary Gland Neoplasm 4 | 6
Parathyroid Adenoma 4 | 19
Parathyroid hyperplasia 4 | 6
Peptic Ulcer 4 | 27
Pick disease 4 | 1,894
Pituitary growth hormone cell adenoma 4 | 8
Prolactinoma 4 | 11
Prostatic Neoplasms 4 | 495
Schizophrenia 4 | 1,160
Stomach Neoplasms 4 | 300
Zollinger-Ellison syndrome 4 | 18
acute myeloid leukemia 4 | 783
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
intermittent abdominal pain 4 | 9
nasopharyngeal carcinoma 4 | 1,058
Adenoma 3 | 167
Amyotrophic lateral sclerosis 3 | 451
Autosomal recessive predisposition 3 | 1,442
Carcinoma, Hepatocellular 3 | 228
Liver Cirrhosis, Experimental 3 | 769
Lymphoma 3 | 81
MELANOMA, CUTANEOUS MALIGNANT, 1 3 | 13
Melanocytic nevus 3 | 43
Nevus 3 | 19
Ovarian Neoplasms 3 | 102
Squamous cell carcinoma 3 | 129
cutaneous lupus erythematosus 3 | 1,057
interstitial cystitis 3 | 2,312
ovarian neoplasm 3 | 99
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
Leukemia 2 | 104
Polycystic ovary syndrome 2 | 360
Small nose 2 | 132

Tissue

Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Liver and Pancreas 34 | 16,750
Nervous System 34 | 16,725
Skin and soft tissues 34 | 17,230
Blood and immune system 33 | 16,909
Female tissues 33 | 17,400
Male tissues 33 | 17,142
Respiratory system 33 | 16,393
Urinary Tract 33 | 16,678
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 14 | 4,145
Kinase 2 | 634

GO Process

regulation of cyclin-dependent... 35 | 35
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ISG15--protein ligase HERC5 HERC5 Tbio Enzyme -1.63055 44.5 57
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
SERTA domain-containing protein 1 SERTAD1 Tbio Non-IDG -1.23284 20.9 135
G2/mitotic-specific cyclin-B3 CCNB3 Tbio Non-IDG -1.07824 12.1 272
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.17357 1313.4 105
Cyclin-Y-like protein 2 CCNYL2 Tdark Non-IDG 0.00000 0
Hsp90 co-chaperone Cdc37 CDC37 Tbio Non-IDG -0.96438 12.8 409
Cyclin-dependent kinase 5 activator 2 CDK5R2 Tbio Enzyme -0.66336 5.03 130
Cyclin-dependent kinase 4 inhibitor B CDKN2B Tbio Enzyme -2.61258 428.8 451
Cyclin-dependent kinase 4 inhibitor C CDKN2C Tbio Enzyme -1.97718 112.7 386