Development Level

Tchem 19 | 1,598
Tbio 13 | 11,445
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
embryonic growth retardation 1 | 106
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 24 | 8,520
Carcinoma 23 | 11,493
psoriasis 22 | 6,694
osteosarcoma 21 | 7,950
malignant mesothelioma 17 | 3,232
medulloblastoma, large-cell 17 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Breast cancer 11 | 3,578
Cancer 11 | 2,499
Carcinoma, Hepatocellular 11 | 228
Liver carcinoma 11 | 240
Pick disease 11 | 1,894
atypical teratoid / rhabdoid tumor 11 | 5,112
ductal carcinoma in situ 11 | 1,745
glioblastoma 11 | 5,792
Obesity 10 | 678
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung cancer 10 | 4,740
invasive ductal carcinoma 9 | 2,951
Fatty liver disease 8 | 103
active Crohn's disease 8 | 922
interstitial cystitis 8 | 2,312
diabetes mellitus 7 | 1,728
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
Autosomal recessive predisposition 6 | 1,442
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
group 4 medulloblastoma 6 | 1,855
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Atherosclerosis 5 | 291
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
Lipid metabolism disorder 5 | 114
acute quadriplegic myopathy 5 | 1,158
ependymoma 5 | 4,679
pediatric high grade glioma 5 | 1,064
Cataract 4 | 297
Cognitive delay 4 | 608
Epilepsy 4 | 792
Global developmental delay 4 | 608
Kidney Failure, Chronic 4 | 46
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Porokeratosis of Mibelli 4 | 4
Seizures 4 | 596
Small head 4 | 374
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
Chagas disease 3 | 39
Congenital deafness 3 | 185
Deafness 3 | 198
Dull intelligence 3 | 645
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Fetal Growth Retardation 3 | 189
Hearing Loss, Partial 3 | 185
Heart failure 3 | 162
Hydrolethalus syndrome 3 | 128
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Lens Opacities 3 | 231
Liver Cirrhosis, Experimental 3 | 769
Liver cancer 3 | 604
Low intelligence 3 | 645
Low set ears 3 | 181
Melanoma 3 | 711
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
Poor school performance 3 | 645
Schizophrenia 3 | 1,160
Short stature 3 | 531
Ulnar polydactyly of fingers 3 | 47
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
chronic rhinosinusitis 3 | 512
esophageal adenocarcinoma 3 | 737
gastric cancer 3 | 459
hearing impairment 3 | 199
hepatocellular carcinoma 3 | 547
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
tuberculosis 3 | 2,010

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678
Nervous System 33 | 16,725
Respiratory system 33 | 16,393

Target Family

Enzyme 22 | 4,145
Transcription Factor 6 | 1,400
Non-IDG 5 | 12,091
Kinase 1 | 634

GO Process

regulation of cholesterol bios... 34 | 34
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
SEC14-like protein 2 SEC14L2 Tbio Non-IDG -1.94705 87.1 159
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Acetyl-CoA carboxylase 2 ACACB Tchem Enzyme -2.25387 171.9 125
Lathosterol oxidase SC5D Tbio Enzyme -1.42233 28.3 26
Elongation of very long chain fatty acids protein 6 ELOVL6 Tchem Non-IDG -1.88496 74.1 147