Development Level

Tbio 95 | 11,445
Tchem 55 | 1,598
Tclin 21 | 613
Tdark 6 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
decreased vertical activity 5 | 208
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
enlarged heart 3 | 210
impaired glucose tolerance 3 | 75
increased startle reflex 3 | 112
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased T cell number 2 | 15
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased total body fat amoun... 2 | 134
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal iris transilluminatio... 1 | 2
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
absent testes 1 | 6
anophthalmia 1 | 33
cornea ulcer 1 | 1
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
fused cornea and lens 1 | 5
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased CD4-positive, alpha ... 1 | 4
increased basophil cell number 1 | 7
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating triglyce... 1 | 42
increased coping response 1 | 4
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased vertical activity 1 | 24
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
prenatal lethality 1 | 28
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 103 | 11,493
Cancer 99 | 2,499
ovarian cancer 99 | 8,520
osteosarcoma 93 | 7,950
psoriasis 79 | 6,694
lung cancer 73 | 4,740
medulloblastoma, large-cell 66 | 6,241
glioblastoma 62 | 5,792
malignant mesothelioma 60 | 3,232
interstitial cystitis 54 | 2,312
pancreatic cancer 53 | 2,398
non-small cell lung cancer 49 | 2,890
atypical teratoid / rhabdoid tumor 48 | 5,112
Breast cancer 46 | 3,578
lung adenocarcinoma 45 | 2,716
lung carcinoma 45 | 2,843
ependymoma 42 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
invasive ductal carcinoma 40 | 2,951
tuberculosis 40 | 2,010
group 3 medulloblastoma 39 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
ulcerative colitis 36 | 1,819
Kidney cancer 35 | 2,613
adult high grade glioma 32 | 3,801
subependymal giant cell astrocytoma 32 | 2,287
cystic fibrosis 30 | 1,696
pituitary cancer 30 | 1,972
Rheumatoid arthritis 29 | 1,191
cutaneous lupus erythematosus 29 | 1,057
oligodendroglioma 28 | 2,850
Astrocytoma, Pilocytic 27 | 3,081
colon cancer 27 | 1,478
group 4 medulloblastoma 26 | 1,855
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
primitive neuroectodermal tumor 25 | 3,035
ductal carcinoma in situ 24 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Autosomal recessive predisposition 22 | 1,442
Schizophrenia 22 | 1,160
breast carcinoma 22 | 1,638
diabetes mellitus 22 | 1,728
Liver Cirrhosis, Experimental 21 | 769
Pick disease 21 | 1,894
primary pancreatic ductal adenocarcinoma 21 | 1,109
Kidney disease 19 | 430
astrocytoma 19 | 1,146
juvenile dermatomyositis 19 | 1,187
active Crohn's disease 18 | 922
Blastic phase chronic myeloid leukemia 17 | 58
Chronic Myelocytic Leukemia Accelerated Phase 17 | 59
Chronic phase chronic myeloid leukemia 17 | 45
Hypersensitivity reaction type II disease 17 | 253
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 17 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 17 | 47
adrenocortical carcinoma 17 | 1,428
dermatomyositis 17 | 966
nasopharyngeal carcinoma 17 | 1,058
spina bifida 17 | 1,074
Multiple Sclerosis 16 | 540
astrocytic glioma 16 | 2,597
Hypertension 15 | 396
gastric carcinoma 15 | 807
pancreatic carcinoma 15 | 562
primary Sjogren syndrome 15 | 735
Arthritis 14 | 290
Prostatic Neoplasms 14 | 495
Seizures 14 | 596
Asthma 13 | 385
Atopic dermatitis 13 | 952
Depressive disorder 13 | 409
Epilepsy 13 | 792
Splenomegaly 13 | 190
active ulcerative colitis 13 | 764
esophageal adenocarcinoma 13 | 737
Anemia 12 | 365
Atherosclerosis 12 | 291
Bipolar Disorder 12 | 666
Hypertensive disease 12 | 292
Intellectual disability 12 | 1,016
Lung Neoplasms 12 | 232
acute myeloid leukemia 12 | 783
acute quadriplegic myopathy 12 | 1,158
mucosa-associated lymphoid tissue lymphoma 12 | 484
Arthritis, Rheumatoid 11 | 174
Immune system cancer 11 | 140
Lymphoid leukemia 11 | 160
Obesity 11 | 678
Stomach Neoplasms 11 | 300
Thrombocytopenia 11 | 197
pediatric high grade glioma 11 | 1,064
Coronary artery disease 10 | 268
Lung disease 10 | 142
Mental Depression 10 | 333
Short stature 10 | 531
Waldenstrons macroglobulinemia 10 | 765
nephrosclerosis 10 | 333
Crohn's disease 9 | 321

Tissue

Digestive Tract 173 | 17,369
Female tissues 171 | 17,400
Endocrine System 170 | 18,159
Male tissues 170 | 17,142
Skin and soft tissues 170 | 17,230
Blood and immune system 169 | 16,909
Liver and Pancreas 169 | 16,750
Urinary Tract 169 | 16,678
Respiratory system 168 | 16,393
Nervous System 167 | 16,725
Cardiovascular System 156 | 15,192

Target Family

Non-IDG 82 | 12,091
Kinase 36 | 634
Transcription Factor 25 | 1,400
Enzyme 23 | 4,145
GPCR 4 | 408
Ion Channel 3 | 344
Epigenetic 2 | 242
Nuclear Receptor 2 | 48

GO Process

regulation of cell proliferati... 177 | 177
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Homeobox protein ARX ARX Tbio Transcription Factor -2.21255 163.7 328
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Gastrokine-2 GKN2 Tbio Non-IDG -2.35485 155.7 66
Calcium and integrin-binding protein 1 CIB1 Tbio Non-IDG -2.08897 121.1 264
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
Marginal zone B- and B1-cell-specific protein MZB1 Tbio Non-IDG -1.11106 17.1 71
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231