Development Level

Tbio 67 | 11,651
Tchem 18 | 1,388
Tdark 6 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 4 | 499
decreased basophil cell number 3 | 16
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
decreased vertical activity 2 | 208
female infertility 2 | 60
increased monocyte cell number 2 | 63
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
long tibia 1 | 25
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74
urinary bladder obstruction 1 | 4

Disease

Carcinoma 62 | 11,493
ovarian cancer 62 | 8,520
osteosarcoma 49 | 7,950
Cancer 48 | 2,499
psoriasis 46 | 6,694
medulloblastoma, large-cell 44 | 6,241
glioblastoma 40 | 5,792
lung cancer 38 | 4,740
atypical teratoid / rhabdoid tumor 37 | 5,112
group 3 medulloblastoma 35 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
Breast cancer 28 | 3,578
lung adenocarcinoma 28 | 2,716
non-small cell lung cancer 28 | 2,890
primitive neuroectodermal tumor 28 | 3,035
ependymoma 27 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
adult high grade glioma 26 | 3,801
invasive ductal carcinoma 24 | 2,951
malignant mesothelioma 23 | 3,232
adrenocortical carcinoma 22 | 1,428
pancreatic cancer 19 | 2,398
breast carcinoma 18 | 1,638
Multiple myeloma 17 | 1,332
ductal carcinoma in situ 17 | 1,745
subependymal giant cell astrocytoma 17 | 2,287
tuberculosis 17 | 2,010
Kidney cancer 16 | 2,613
Waldenstrons macroglobulinemia 16 | 765
interstitial cystitis 16 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
astrocytoma 15 | 1,146
lung carcinoma 15 | 2,843
juvenile dermatomyositis 14 | 1,187
pituitary cancer 14 | 1,972
Astrocytoma, Pilocytic 13 | 3,081
astrocytic glioma 13 | 2,597
dermatomyositis 13 | 966
diabetes mellitus 13 | 1,728
oligodendroglioma 13 | 2,850
Breast Neoplasms 12 | 445
Endometriosis 12 | 540
Mammary Neoplasms 12 | 425
nasopharyngeal carcinoma 12 | 1,058
Atopic dermatitis 11 | 952
acute myeloid leukemia 11 | 783
colon cancer 11 | 1,478
group 4 medulloblastoma 10 | 1,855
Pick disease 9 | 1,894
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
Stomach Neoplasms 9 | 300
cystic fibrosis 9 | 1,696
primary pancreatic ductal adenocarcinoma 9 | 1,109
ulcerative colitis 9 | 1,819
Colonic Neoplasms 8 | 142
Liver Cirrhosis, Experimental 8 | 769
Bipolar Disorder 7 | 666
Carcinoma, Hepatocellular 7 | 228
Carcinoma, Squamous Cell 7 | 110
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Renal Cell Carcinoma 7 | 214
Squamous cell carcinoma 7 | 129
Vascular disease 7 | 319
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Arthritis 6 | 290
Heart disease 6 | 306
Intellectual disability 6 | 1,016
Leukemia 6 | 104
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Multiple Sclerosis 6 | 540
Obesity 6 | 678
Ovarian Neoplasms 6 | 102
Polycystic ovary syndrome 6 | 360
cutaneous lupus erythematosus 6 | 1,057
gastric cancer 6 | 459
ovarian neoplasm 6 | 99
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Amyotrophic lateral sclerosis 5 | 451
Cognitive delay 5 | 608
Crohn's disease 5 | 321
Depressive disorder 5 | 409
Down syndrome 5 | 499
Global developmental delay 5 | 608
Kidney disease 5 | 430
Mental and motor retardation 5 | 608
Seizures 5 | 596
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
aldosterone-producing adenoma 5 | 665
chronic rhinosinusitis 5 | 512
esophageal adenocarcinoma 5 | 737
medulloblastoma 5 | 720
non primary Sjogren syndrome sicca 5 | 891
Prostatic Neoplasms 4 | 495
nephrosclerosis 4 | 333
spina bifida 4 | 1,074

Tissue

Endocrine System 94 | 18,159
Female tissues 94 | 17,400
Blood and immune system 93 | 16,909
Digestive Tract 93 | 17,369
Liver and Pancreas 93 | 16,750
Respiratory system 93 | 16,393
Skin and soft tissues 93 | 17,230
Male tissues 92 | 17,142
Nervous System 92 | 16,725
Urinary Tract 91 | 16,678
Cardiovascular System 88 | 15,192

Target Family

Non-IDG 55 | 12,091
Transcription Factor 14 | 1,400
Enzyme 12 | 4,145
Kinase 7 | 634
Epigenetic 3 | 242
TF/Epigenetic 2 | 38
Ion Channel 1 | 344

GO Process

regulation of cell cycle 94 | 94
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
Lethal(3)malignant brain tumor-like protein 1 L3MBTL1 Tchem TF/Epigenetic -2.45676 284.5 106
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.62435 385.9 321
Period circadian protein homolog 2 PER2 Tchem Non-IDG -2.67778 457.4 219
Denticleless protein homolog DTL Tbio Non-IDG -1.63065 50.0 160
Histone-binding protein RBBP4 RBBP4 Tbio Non-IDG -1.71209 53.9 310
Ribosome biogenesis protein NOP53 NOP53 Tbio Non-IDG -1.35132 27.1 155
Receptor of activated protein C kinase 1 RACK1 Tbio Non-IDG -2.60480 437.9 300
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351