Development Level

Tbio 31 | 11,651
Tchem 18 | 1,388
Tclin 16 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal gait 2 | 69
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
prolonged ST segment 2 | 36
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal eating behavior 1 | 1
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal forced expiratory flo... 1 | 1
abnormal heart morphology 1 | 162
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
head bobbing 1 | 5
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38

Disease

Carcinoma 45 | 11,493
Hypertension 40 | 396
psoriasis 35 | 6,694
lung cancer 30 | 4,740
glioblastoma 29 | 5,792
ovarian cancer 29 | 8,520
Hypertensive disease 27 | 292
diabetes mellitus 27 | 1,728
atypical teratoid / rhabdoid tumor 25 | 5,112
medulloblastoma, large-cell 25 | 6,241
Cancer 24 | 2,499
ependymoma 24 | 4,679
osteosarcoma 24 | 7,950
adult high grade glioma 23 | 3,801
invasive ductal carcinoma 23 | 2,951
lung carcinoma 23 | 2,843
Heart disease 21 | 306
Heart failure 20 | 162
Cerebrovascular disease 19 | 238
Kidney disease 19 | 430
ductal carcinoma in situ 19 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
lung adenocarcinoma 19 | 2,716
Autosomal recessive predisposition 18 | 1,442
Breast cancer 18 | 3,578
Obesity 18 | 678
breast carcinoma 18 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
non-small cell lung cancer 18 | 2,890
pancreatic cancer 18 | 2,398
Astrocytoma, Pilocytic 17 | 3,081
Coronary artery disease 17 | 268
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
malignant mesothelioma 17 | 3,232
Kidney cancer 16 | 2,613
Schizophrenia 16 | 1,160
colon cancer 16 | 1,478
group 3 medulloblastoma 16 | 4,104
Depressive disorder 15 | 409
primitive neuroectodermal tumor 15 | 3,035
Atherosclerosis 14 | 291
Bipolar Disorder 14 | 666
oligodendroglioma 14 | 2,850
tuberculosis 14 | 2,010
ulcerative colitis 14 | 1,819
Major Depressive Disorder 13 | 301
Myocardial Infarction 13 | 151
cystic fibrosis 13 | 1,696
Alzheimer's disease 11 | 658
Cardiomegaly 11 | 116
Mental Depression 11 | 333
Osteoporosis 11 | 363
Seizures 11 | 596
adrenocortical carcinoma 11 | 1,428
astrocytic glioma 11 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
Anemia 10 | 365
Asthma 10 | 385
Diabetes Mellitus, Experimental 10 | 108
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Diabetes Mellitus, Type 2 10 | 142
Hyperglycemia 10 | 137
Liver Cirrhosis, Experimental 10 | 769
Lung disease 10 | 142
Melanoma 10 | 711
Pick disease 10 | 1,894
Pulmonary hypertension 10 | 86
subependymal giant cell astrocytoma 10 | 2,287
Adenoma 9 | 167
Arthritis 9 | 290
Atopic dermatitis 9 | 952
Breast Neoplasms 9 | 445
Hypotension 9 | 82
Mammary Neoplasms 9 | 425
Pain 9 | 103
Prostatic Neoplasms 9 | 495
Unipolar Depression 9 | 250
Fibrosis 8 | 44
Hyperinsulinism 8 | 133
Inflammation 8 | 120
Kidney Diseases 8 | 114
Liver Cirrhosis 8 | 181
Liver disease 8 | 237
Migraine 8 | 83
Myocardial Ischemia 8 | 169
Reperfusion Injury 8 | 86
active Crohn's disease 8 | 922
juvenile dermatomyositis 8 | 1,187
nephrosclerosis 8 | 333
Atrial Fibrillation 7 | 124
Colonic Neoplasms 7 | 142
Epilepsy 7 | 792
Essential Hypertension 7 | 94
Hypothyroidism 7 | 122
Parkinson's disease 7 | 392
Stomach Neoplasms 7 | 300
esophageal adenocarcinoma 7 | 737
primary pancreatic ductal adenocarcinoma 7 | 1,109

Tissue

Endocrine System 65 | 18,159
Male tissues 63 | 17,142
Digestive Tract 62 | 17,369
Liver and Pancreas 62 | 16,750
Female tissues 61 | 17,400
Skin and soft tissues 61 | 17,230
Urinary Tract 60 | 16,678
Blood and immune system 59 | 16,909
Respiratory system 58 | 16,393
Nervous System 57 | 16,725
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 22 | 4,145
GPCR 7 | 408
Kinase 5 | 634
Ion Channel 3 | 344
Transporter 2 | 473
Nuclear Receptor 1 | 48

GO Process

regulation of blood pressure 65 | 65
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tbio Enzyme -1.62910 39.1 51
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103
Natriuretic peptides A NPPA Tchem Non-IDG -3.25145 1788.9 509
Type-2 angiotensin II receptor AGTR2 Tchem GPCR -3.30172 1972.1 147
Endoplasmic reticulum aminopeptidase 1 ERAP1 Tchem Enzyme -2.32434 221.0 216
Natriuretic peptides B NPPB Tbio Non-IDG -3.36837 2242.8 945
Pro-opiomelanocortin POMC Tbio Non-IDG -4.56004 36591.2 1334