Development Level

Tbio 60 | 11,445
Tdark 13 | 6,588
Tchem 2 | 1,598
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
abnormal brain morphology 1 | 13
abnormal coat- hair morphology 1 | 19
abnormal eye anterior chamber ... 1 | 9
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cataract 1 | 92
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mature B cell number 1 | 1
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
male infertility 1 | 123
short tibia 1 | 97
syndactyly 1 | 23
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 71 | 11,493
medulloblastoma, large-cell 41 | 6,241
osteosarcoma 41 | 7,950
ovarian cancer 41 | 8,520
glioblastoma 36 | 5,792
Kidney cancer 35 | 2,613
atypical teratoid / rhabdoid tumor 35 | 5,112
ependymoma 27 | 4,679
psoriasis 27 | 6,694
adult high grade glioma 26 | 3,801
group 3 medulloblastoma 26 | 4,104
primitive neuroectodermal tumor 24 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Astrocytoma, Pilocytic 20 | 3,081
invasive ductal carcinoma 20 | 2,951
lung cancer 20 | 4,740
non-small cell lung cancer 20 | 2,890
Breast cancer 19 | 3,578
malignant mesothelioma 19 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
subependymal giant cell astrocytoma 18 | 2,287
Cancer 16 | 2,499
astrocytic glioma 16 | 2,597
lung adenocarcinoma 16 | 2,716
lung carcinoma 16 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
oligodendroglioma 15 | 2,850
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,855
Pick disease 13 | 1,894
pancreatic cancer 13 | 2,398
spina bifida 12 | 1,074
breast carcinoma 11 | 1,638
interstitial cystitis 11 | 2,312
tuberculosis 11 | 2,010
Intellectual disability 10 | 1,016
pituitary cancer 10 | 1,972
ulcerative colitis 10 | 1,819
Liver cancer 9 | 604
cystic fibrosis 9 | 1,696
Aarskog syndrome 7 | 12
aldosterone-producing adenoma 7 | 665
colon cancer 7 | 1,478
cutaneous lupus erythematosus 7 | 1,057
active Crohn's disease 6 | 922
primary Sjogren syndrome 6 | 735
Chronic Lymphocytic Leukemia 5 | 262
Endometrial cancer 5 | 311
Melanoma 5 | 711
Short stature 5 | 531
Skin cancer 5 | 469
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
medulloblastoma 5 | 720
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Blepharoptosis 4 | 231
Breast Neoplasms 4 | 445
Cryptorchidism 4 | 296
Curvature of spine 4 | 282
Downward slant of palpebral fissure 4 | 158
Dull intelligence 4 | 645
Joint hyperflexibility 4 | 78
Liver Cirrhosis, Experimental 4 | 769
Low intelligence 4 | 645
Low-set, posteriorly rotated ears 4 | 110
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neuropathy 4 | 261
Orbital separation excessive 4 | 244
Pectus excavatum 4 | 100
Poor school performance 4 | 645
Schizophrenia 4 | 1,160
Short neck 4 | 140
Strabismus 4 | 270
acute quadriplegic myopathy 4 | 1,158
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
mucosa-associated lymphoid tissue lymphoma 4 | 484
nasopharyngeal carcinoma 4 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
Bipolar Disorder 3 | 666
Byzanthine arch palate 3 | 194
Delayed bone age 3 | 136
Dysarthria 3 | 192
Exophthalmos 3 | 112
Hepatomegaly 3 | 285
Lymphangioma, Cystic 3 | 21
Multiple Sclerosis 3 | 540
Neurodegenerative disease 3 | 414
Polycystic ovary syndrome 3 | 360
Triangular face 3 | 58
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 77 | 16,909
Digestive Tract 77 | 17,369
Endocrine System 77 | 18,159
Female tissues 77 | 17,400
Male tissues 77 | 17,142
Respiratory system 77 | 16,393
Urinary Tract 77 | 16,678
Liver and Pancreas 76 | 16,750
Skin and soft tissues 75 | 17,230
Nervous System 74 | 16,725
Cardiovascular System 73 | 15,192

Target Family

Non-IDG 71 | 12,091
Kinase 4 | 634
Enzyme 2 | 4,145

GO Process

regulation of Rho protein sign... 77 | 77
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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