Development Level

Tbio 16 | 11,651
Tchem 6 | 1,388

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
absent pinna reflex 1 | 23
cataract 1 | 92
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased lactate dehydrogenas... 1 | 16
increased eosinophil cell numb... 1 | 11
increased lean body mass 1 | 172
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 13 | 11,493
ovarian cancer 13 | 8,520
osteosarcoma 11 | 7,950
Autosomal recessive predisposition 8 | 1,442
lung cancer 8 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Multiple myeloma 7 | 1,332
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
Acidosis, Lactic 6 | 97
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
ependymoma 6 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
Breast cancer 5 | 3,578
Cancer 5 | 2,499
Lactic acidemia 5 | 95
Lactic acidosis 5 | 51
Leigh disease 5 | 100
Pyruvate decarboxylase deficiency 5 | 16
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
non-small cell lung cancer 5 | 2,890
psoriasis 5 | 6,694
Epilepsy 4 | 792
Hypoglycemia 4 | 152
Kidney cancer 4 | 2,613
Liver Cirrhosis, Experimental 4 | 769
Schizophrenia 4 | 1,160
Seizures 4 | 596
Small head 4 | 374
active ulcerative colitis 4 | 764
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
group 3 medulloblastoma 4 | 4,104
primitive neuroectodermal tumor 4 | 3,035
Bipolar Disorder 3 | 666
Cerebellar Ataxia 3 | 304
Dull intelligence 3 | 645
Dystonia 3 | 164
Dystonic disease 3 | 106
Hyper-beta-alaninemia 3 | 9
Increased blood alanine 3 | 9
Increased serum alanine 3 | 9
Increased serum lactate 3 | 60
Increased serum pyruvate 3 | 9
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Myocardial Infarction 3 | 151
Pick disease 3 | 1,894
Poor school performance 3 | 645
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
hereditary spastic paraplegia 3 | 318
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
ulcerative colitis 3 | 1,819
Abnormal ocular motility 2 | 19
Atopic dermatitis 2 | 952
Blepharoptosis 2 | 231
Breast Neoplasms 2 | 445
Creatine phosphokinase serum increased 2 | 110
Down syndrome 2 | 499
Elevated creatine kinase 2 | 110
Endometriosis 2 | 540
Feeding difficulties 2 | 127
Highly variable severity 2 | 157
Infantile onset 2 | 238
Lethargy 2 | 77
Mammary Neoplasms 2 | 425
Mental Depression 2 | 333
Myocardial Ischemia 2 | 169
Neonatal Hypotonia 2 | 64
Neoplasm Invasiveness 2 | 161
Obesity 2 | 678
Prenatal onset 2 | 139
Prostatic Neoplasms 2 | 495
Renal Cell Carcinoma 2 | 214
Rheumatoid arthritis 2 | 1,191
Variable expressivity 2 | 157
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
cutaneous lupus erythematosus 2 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
nasopharyngeal carcinoma 2 | 1,058
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Endocrine System 22 | 18,159
Digestive Tract 21 | 17,369
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678
Blood and immune system 20 | 16,909
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Cardiovascular System 19 | 15,192
Respiratory system 19 | 16,393

Target Family

Enzyme 14 | 4,145
Non-IDG 4 | 12,091
Transporter 3 | 473
Kinase 1 | 634

GO Process

pyruvate metabolic process 22 | 22
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Monocarboxylate transporter 3 SLC16A8 Tbio Transporter -1.52718 33.5 105
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial PDHA2 Tbio Enzyme -1.11924 13.9 89
Acyl-coenzyme A thioesterase 12 ACOT12 Tbio Enzyme -1.10413 12.4 95
L-lactate dehydrogenase A-like 6B LDHAL6B Tbio Enzyme -1.70845 50.7 108
Monocarboxylate transporter 4 SLC16A3 Tchem Transporter -1.33148 17.9 161
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -3.03454 1030.5 577
Basigin BSG Tbio Non-IDG -3.08142 1335.4 1225
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB Tbio Enzyme -1.71672 48.4 149
L-lactate dehydrogenase B chain LDHB Tchem Enzyme -2.50076 306.0 241
Pyruvate dehydrogenase protein X component, mitochondrial PDHX Tbio Enzyme -2.44833 258.7 215