Development Level

Tbio 5 | 11,445
Tchem 1 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to o... 2 | 239
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
microphthalmia 1 | 26

Disease

psoriasis 7 | 6,694
Carcinoma 6 | 11,493
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
glioblastoma 5 | 5,792
invasive ductal carcinoma 5 | 2,951
medulloblastoma, large-cell 5 | 6,241
Breast cancer 4 | 3,578
Lesch-Nyhan syndrome 4 | 12
Purine nucleoside phosphorylase deficiency 4 | 11
adult high grade glioma 4 | 3,801
cystic fibrosis 4 | 1,696
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Poor school performance 3 | 645
breast carcinoma 3 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
osteosarcoma 3 | 7,950
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Absent speech 2 | 43
Arthritis, Gouty 2 | 9
Cognitive delay 2 | 608
Deglutition Disorders 2 | 132
Epilepsy 2 | 792
Global developmental delay 2 | 608
Gout 2 | 106
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hyperuricemia 2 | 49
Influenza 2 | 142
Influenza, Human 2 | 51
Kidney Failure 2 | 111
Mental and motor retardation 2 | 608
Microphthalmia with limb anomalies 2 | 40
Motor delay 2 | 147
Multiple Sclerosis 2 | 540
No development of motor milestones 2 | 147
Nystagmus 2 | 317
Opisthotonus 2 | 14
Poor growth 2 | 114
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Seizures 2 | 596
Systemic lupus erythematosus 2 | 194
Uric acid concentration in urine above normal 2 | 3
Very poor growth 2 | 114
Waldenstrons macroglobulinemia 2 | 765
West Nile encephalitis 2 | 9
X- linked recessive 2 | 110
Xanthinuria 2 | 10
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung carcinoma 2 | 2,843
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
nonverbal 2 | 43
posterior fossa group B ependymoma 2 | 416
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
Arts syndrome 1 | 26
Candidiasis 1 | 55
Charcot-Marie-Tooth disease 1 | 62
Childhood onset 1 | 38
Congenital heart disease 1 | 93
Decreased nerve conduction velocity 1 | 35
Dental caries 1 | 164
Eczema herpeticum 1 | 7
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Hepatitis C 1 | 94
Hyperactive behavior 1 | 91
Hyperhomocysteinemia 1 | 37
Immunologic Deficiency Syndromes 1 | 113
Muscle Weakness 1 | 170
Myoclonus 1 | 74
Neural Tube Defects 1 | 31
Neural tube defect, folate-sensitive 1 | 4
Recurrent infections 1 | 48
Recurrent upper respiratory tract infection 1 | 21
Thin upper lip vermilion 1 | 67
Weight Gain 1 | 100
neural tube defect 1 | 9

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Enzyme 7 | 4,145
Kinase 1 | 634

GO Process

purine nucleotide biosynthetic... 8 | 8
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
2'-5'-oligoadenylate synthase 1 OAS1 Tbio Enzyme -2.01318 92.3 238
Adenylosuccinate lyase ADSL Tbio Enzyme -3.32293 2023.8 144
2'-5'-oligoadenylate synthase 2 OAS2 Tbio Enzyme -1.41496 20.8 293
Hypoxanthine-guanine phosphoribosyltransferase HPRT1 Tchem Enzyme -3.37307 2350.7 381
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 MTHFD2L Tdark Enzyme -0.45230 2.70 114
Amidophosphoribosyltransferase PPAT Tclin Enzyme -1.75730 56.1 198
Ribose-phosphate pyrophosphokinase 1 PRPS1 Tbio Kinase -1.80381 66.0 97