Development Level

Tchem 94 | 1,890
Tbio 81 | 10,625
Tdark 16 | 7,003
Tclin 8 | 602

IMPC Term

abnormal bone mineralization 4 | 55
preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased total body fat amoun... 3 | 186
short tibia 3 | 82
abnormal cranium morphology 2 | 32
abnormal eye morphology 2 | 38
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal vibrissa morphology 2 | 17
anophthalmia 2 | 20
decreased circulating aspartat... 2 | 27
decreased circulating triglyce... 2 | 83
decreased heart weight 2 | 44
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
hyperactivity 2 | 108
increased B cell number 2 | 23
increased CD8-positive, alpha-... 2 | 11
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal body size 1 | 1
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal esophagus morphology 1 | 4
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal incisor morphology 1 | 3
abnormal joint morphology 1 | 14
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal placenta size 1 | 10
abnormal radius morphology 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal spinal cord morpholog... 1 | 8
abnormal stomach morphology 1 | 4
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
absent heartbeat 1 | 6
absent lymph nodes 1 | 3
convulsive seizures 1 | 11
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating phosphat... 1 | 15
decreased gamma-delta T cell n... 1 | 18
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased KLRG1-positive NK ce... 1 | 9
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
oligodactyly 1 | 14
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
short tail 1 | 4
small testis 1 | 37
thick tail 1 | 1
tremors 1 | 34

Disease

ovarian cancer 101 | 8,484
osteosarcoma 92 | 7,933
psoriasis 81 | 6,685
glioblastoma 60 | 5,572
lung cancer 53 | 4,466
medulloblastoma, large-cell 53 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 51 | 3,289
Cancer 48 | 2,346
non-small cell lung cancer 44 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,956
atypical teratoid / rhabdoid tumor 41 | 4,369
Breast cancer 40 | 3,094
invasive ductal carcinoma 40 | 2,950
lung carcinoma 40 | 2,844
diabetes mellitus 39 | 1,663
malignant mesothelioma 39 | 3,162
cystic fibrosis 37 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
pancreatic cancer 37 | 2,300
lung adenocarcinoma 36 | 2,713
ulcerative colitis 36 | 2,087
pilocytic astrocytoma 35 | 3,086
interstitial cystitis 30 | 2,299
oligodendroglioma 29 | 2,849
adult high grade glioma 27 | 2,148
subependymal giant cell astrocytoma 27 | 2,287
breast carcinoma 25 | 1,614
pediatric high grade glioma 25 | 2,712
Atopic dermatitis 24 | 944
Alzheimer's disease 22 | 644
Carcinoma 22 | 2,147
cutaneous lupus erythematosus 20 | 1,056
ductal carcinoma in situ 20 | 1,745
posterior fossa group A ependymoma 20 | 1,511
primary pancreatic ductal adenocarcinoma 20 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
primitive neuroectodermal tumor 19 | 3,031
Multiple myeloma 18 | 1,327
astrocytic glioma 18 | 2,241
group 4 medulloblastoma 18 | 1,875
tuberculosis 18 | 1,557
colon cancer 17 | 1,475
group 3 medulloblastoma 17 | 2,254
active Crohn's disease 16 | 918
astrocytoma 16 | 1,493
esophageal adenocarcinoma 16 | 737
Pick disease 15 | 1,893
acute quadriplegic myopathy 15 | 1,157
gastric carcinoma 15 | 832
juvenile dermatomyositis 15 | 1,189
sonic hedgehog group medulloblastoma 15 | 1,482
ependymoma 14 | 2,514
Arthritis 13 | 248
Rheumatoid Arthritis 13 | 1,160
nasopharyngeal carcinoma 13 | 1,056
pituitary cancer 13 | 1,972
Duchenne muscular dystrophy 12 | 602
Hypertension 12 | 287
Kidney disease 12 | 396
Obesity 12 | 616
Pancreatitis 12 | 97
Prostatic Neoplasms 12 | 471
Vascular disease 12 | 281
inflammatory breast cancer 12 | 404
medulloblastoma 12 | 1,524
periodontitis 12 | 269
Waldenstrons macroglobulinemia 11 | 765
dermatomyositis 11 | 933
posterior fossa group B ependymoma 11 | 1,530
primary Sjogren syndrome 11 | 789
Atherosclerosis 10 | 275
Mammary Neoplasms 10 | 410
Myocardial Infarction 10 | 126
fibroadenoma 10 | 557
spina bifida 10 | 1,064
Cerebrovascular disease 9 | 231
Lung disease 9 | 132
Neurodegenerative disease 9 | 383
adrenocortical carcinoma 9 | 1,427
Asthma 8 | 349
Coronary artery disease 8 | 240
Down syndrome 8 | 548
Heart disease 8 | 279
Multiple Sclerosis 8 | 498
Neoplasm Invasiveness 8 | 127
interstitial lung disease 8 | 291
mucosa-associated lymphoid tissue lymphoma 8 | 480
sarcoidosis 8 | 358
Cerebral Hemorrhage 7 | 27
Diabetes Mellitus, Non-Insulin-Dependent 7 | 157
Disseminated intravascular coagulation 7 | 32
Endometriosis 7 | 535
IGA Glomerulonephritis 7 | 454
Liver carcinoma 7 | 217
Periodontal disease 7 | 37
Stomach Neoplasms 7 | 282
active ulcerative colitis 7 | 477
non-small cell lung carcinoma 7 | 413
Prostate cancer 6 | 172
Spontaneous abortion 6 | 108

Tissue

Female tissues 197 | 18,647
Digestive Tract 196 | 18,473
Endocrine System 196 | 18,512
Male tissues 196 | 17,969
Urinary Tract 196 | 18,444
Blood and immune system 195 | 17,995
Nervous System 195 | 18,561
Cardiovascular System 193 | 17,958
Liver and Pancreas 193 | 18,136
Skin and soft tissues 193 | 18,115
Respiratory system 191 | 17,484

Target Family

Enzyme 155 | 4,146
Non-IDG 44 | 11,971

GO Process

proteolysis 199 | 199
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Transmembrane protease serine 7 TMPRSS7 Tdark Enzyme 0.24 0.97 63
Macrophage metalloelastase MMP12 Tchem Enzyme 0.00000 382
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83
Bone morphogenetic protein 1 BMP1 Tchem Non-IDG -2.32178 220.1 155
Cysteine protease ATG4A ATG4A Tbio Enzyme -0.98696 7.89 199
Prolyl endopeptidase PREP Tchem Enzyme -2.51026 335.2 140
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129