Development Level

Tbio 104 | 10,625
Tdark 34 | 7,003
Tchem 11 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 13 | 633
embryonic lethality prior to t... 7 | 187
abnormal behavior 6 | 226
decreased bone mineral content 6 | 157
decreased grip strength 6 | 123
preweaning lethality, incomple... 6 | 260
abnormal embryo size 5 | 112
decreased lean body mass 5 | 195
decreased heart weight 4 | 44
embryonic lethality prior to o... 4 | 148
abnormal bone structure 3 | 131
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating triglyce... 3 | 83
embryonic growth retardation 3 | 28
hyperactivity 3 | 108
increased or absent threshold ... 3 | 128
short tibia 3 | 82
abnormal heart left ventricle ... 2 | 20
abnormal neural tube closure 2 | 37
anophthalmia 2 | 20
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating aspartat... 2 | 27
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased hemoglobin content 2 | 53
decreased respiratory quotient 2 | 12
decreased rib number 2 | 59
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
immune system phenotype 2 | 17
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased grip strength 2 | 83
increased heart weight 2 | 37
increased mean corpuscular vol... 2 | 91
small thymus 2 | 11
tremors 2 | 34
trunk curl 2 | 15
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal craniofacial morpholo... 1 | 12
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal head shape 1 | 4
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal placenta morphology 1 | 4
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal spinal cord morpholog... 1 | 8
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased CD5-positive Ly6C-po... 1 | 4
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
edema 1 | 11
hypoactivity 1 | 89
increased CD4-positive NK T ce... 1 | 3
increased NK T cell number 1 | 11
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
increased memory-marker CD4-po... 1 | 3
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
microphthalmia 1 | 15
narrow eye opening 1 | 15
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
shortened PQ interval 1 | 6
small adrenal glands 1 | 15
small heart 1 | 8
small spleen 1 | 11
straub tail 1 | 26
thrombocytopenia 1 | 46
urinary bladder obstruction 1 | 2
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 104 | 8,484
medulloblastoma, large-cell 73 | 6,234
osteosarcoma 73 | 7,933
glioblastoma 61 | 5,572
psoriasis 57 | 6,685
atypical teratoid / rhabdoid tumor 53 | 4,369
lung cancer 52 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,289
primitive neuroectodermal tumor 37 | 3,031
Breast cancer 31 | 3,094
non-small cell lung cancer 31 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
pediatric high grade glioma 29 | 2,712
pilocytic astrocytoma 29 | 3,086
malignant mesothelioma 28 | 3,162
Cancer 27 | 2,346
medulloblastoma 26 | 1,524
oligodendroglioma 25 | 2,849
subependymal giant cell astrocytoma 25 | 2,287
adrenocortical carcinoma 24 | 1,427
Carcinoma 23 | 2,147
astrocytic glioma 23 | 2,241
ependymoma 23 | 2,514
pancreatic cancer 23 | 2,300
spina bifida 23 | 1,064
adult high grade glioma 22 | 2,148
lung adenocarcinoma 22 | 2,713
group 4 medulloblastoma 21 | 1,875
invasive ductal carcinoma 21 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
Multiple myeloma 17 | 1,327
Pick disease 17 | 1,893
group 3 medulloblastoma 16 | 2,254
lung carcinoma 16 | 2,844
ulcerative colitis 16 | 2,087
posterior fossa group A ependymoma 15 | 1,511
Atopic dermatitis 14 | 944
breast carcinoma 14 | 1,614
interstitial cystitis 14 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Endometriosis 13 | 535
Rheumatoid Arthritis 13 | 1,160
colon cancer 13 | 1,475
ductal carcinoma in situ 13 | 1,745
juvenile dermatomyositis 13 | 1,189
pituitary cancer 13 | 1,972
acute quadriplegic myopathy 12 | 1,157
astrocytoma 12 | 1,493
atypical teratoid/rhabdoid tumor 12 | 1,095
tuberculosis and treatment for 6 months 11 | 686
IGA Glomerulonephritis 10 | 454
acute myeloid leukemia 10 | 780
cystic fibrosis 10 | 1,665
esophageal adenocarcinoma 9 | 737
posterior fossa group B ependymoma 9 | 1,530
primary Sjogren syndrome 9 | 789
sonic hedgehog group medulloblastoma 9 | 1,482
cutaneous lupus erythematosus 8 | 1,056
primary pancreatic ductal adenocarcinoma 8 | 1,271
tuberculosis 8 | 1,557
Intellectual disability 7 | 573
dermatomyositis 7 | 933
diabetes mellitus 7 | 1,663
nasopharyngeal carcinoma 7 | 1,056
active Crohn's disease 6 | 918
gastric carcinoma 6 | 832
hepatocellular carcinoma 6 | 532
non primary Sjogren syndrome sicca 6 | 840
Alzheimer's disease 5 | 644
Hypertension 5 | 287
Mammary Neoplasms 5 | 410
Parkinson's disease 5 | 364
progressive supranuclear palsy 5 | 674
Amyotrophic Lateral Sclerosis 4 | 431
Gaucher disease type 1 4 | 171
Neurodegenerative disease 4 | 383
Peripheral Neuropathy 4 | 303
Prostatic Neoplasms 4 | 471
Stevens-Johnson syndrome 4 | 78
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 664
gastric cancer 4 | 430
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
Colorectal Neoplasms 3 | 217
Disease Progression 3 | 125
Duchenne muscular dystrophy 3 | 602
Influenza 3 | 142
Melanoma 3 | 261
Multiple Sclerosis 3 | 498
Polycystic Ovary Syndrome 3 | 332
Pseudohypoaldosteronism 3 | 22
Renal Cell Carcinoma 3 | 199
Stomach Neoplasms 3 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
hereditary spastic paraplegia 3 | 313
inflammatory breast cancer 3 | 404
sarcoidosis 3 | 358
systemic lupus erythematosus 3 | 156
tuberculosis and treatment for 3 months 3 | 327

Tissue

Liver and Pancreas 150 | 18,136
Blood and immune system 149 | 17,995
Digestive Tract 149 | 18,473
Female tissues 149 | 18,647
Male tissues 149 | 17,969
Nervous System 149 | 18,561
Cardiovascular System 148 | 17,958
Endocrine System 148 | 18,512
Skin and soft tissues 148 | 18,115
Urinary Tract 148 | 18,444
Respiratory system 147 | 17,484

Target Family

Non-IDG 73 | 11,971
Enzyme 71 | 4,146
Kinase 5 | 634
Epigenetic 1 | 242

GO Process

protein ubiquitination involve... 150 | 150
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 Tbio Enzyme -1.57709 42.8 121
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Kelch domain-containing protein 8A KLHDC8A Tdark Non-IDG 0.00000 72
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 21
E3 ubiquitin-protein ligase HACE1 HACE1 Tbio Enzyme -0.48192 4.63 95