Development Level

Tbio 251 | 11,651
Tdark 76 | 6,593
Tchem 18 | 1,388
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, incomple... 19 | 499
preweaning lethality, complete... 17 | 979
abnormal behavior 11 | 298
abnormal bone structure 7 | 187
decreased bone mineral density 7 | 126
increased or absent threshold ... 7 | 101
male infertility 7 | 123
decreased body weight 6 | 161
decreased startle reflex 6 | 75
decreased total body fat amoun... 6 | 207
decreased bone mineral content 5 | 151
decreased circulating chloride... 5 | 30
embryonic lethality prior to t... 5 | 278
hypoactivity 5 | 132
increased circulating HDL chol... 5 | 80
increased lean body mass 5 | 172
increased mean corpuscular hem... 5 | 96
increased mean corpuscular vol... 5 | 92
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
enlarged heart 4 | 210
female infertility 4 | 60
increased heart weight 4 | 62
abnormal bone mineralization 3 | 38
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased blood urea nitrogen ... 3 | 51
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased mean corpuscular hem... 3 | 50
decreased red blood cell distr... 3 | 41
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating phosphat... 3 | 26
increased fasted circulating g... 3 | 76
increased hematocrit 3 | 46
increased mean platelet volume 3 | 45
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal coat appearance 2 | 31
abnormal gait 2 | 69
abnormal retinal blood vessel ... 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased basophil cell number 2 | 16
decreased cardiac muscle contr... 2 | 11
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart rate 2 | 18
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
dilated heart left ventricle 2 | 11
embryonic growth retardation 2 | 106
impaired righting response 2 | 26
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased eosinophil cell numb... 2 | 11
increased lymphocyte cell numb... 2 | 32
prenatal lethality 2 | 28
abnormal cornea morphology 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal vocalization 1 | 21
cystolithiasis 1 | 3
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating potassiu... 1 | 20
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
increased circulating bilirubi... 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 219 | 11,493
ovarian cancer 207 | 8,520
osteosarcoma 158 | 7,950
medulloblastoma, large-cell 126 | 6,241
glioblastoma 122 | 5,792
atypical teratoid / rhabdoid tumor 110 | 5,112
psoriasis 106 | 6,694
lung cancer 95 | 4,740
ependymoma 79 | 4,679
Breast cancer 76 | 3,578
adult high grade glioma 72 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 67 | 3,291
Cancer 65 | 2,499
group 3 medulloblastoma 63 | 4,104
primitive neuroectodermal tumor 60 | 3,035
malignant mesothelioma 59 | 3,232
Kidney cancer 55 | 2,613
oligodendroglioma 55 | 2,850
Astrocytoma, Pilocytic 52 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 52 | 2,989
astrocytic glioma 51 | 2,597
group 4 medulloblastoma 47 | 1,855
invasive ductal carcinoma 46 | 2,951
subependymal giant cell astrocytoma 46 | 2,287
pancreatic cancer 45 | 2,398
non-small cell lung cancer 44 | 2,890
Multiple myeloma 43 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
lung adenocarcinoma 40 | 2,716
tuberculosis 38 | 2,010
breast carcinoma 36 | 1,638
lung carcinoma 35 | 2,843
Pick disease 33 | 1,894
juvenile dermatomyositis 33 | 1,187
spina bifida 33 | 1,074
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
acute quadriplegic myopathy 30 | 1,158
pituitary cancer 30 | 1,972
adrenocortical carcinoma 29 | 1,428
diabetes mellitus 29 | 1,728
ulcerative colitis 28 | 1,819
Rheumatoid arthritis 25 | 1,191
ductal carcinoma in situ 24 | 1,745
Intellectual disability 22 | 1,016
interstitial cystitis 21 | 2,312
Autosomal recessive predisposition 20 | 1,442
astrocytoma 19 | 1,146
tuberculosis and treatment for 6 months 19 | 409
colon cancer 18 | 1,478
dermatomyositis 18 | 966
pediatric high grade glioma 18 | 1,064
medulloblastoma 17 | 720
primary pancreatic ductal adenocarcinoma 17 | 1,109
Waldenstrons macroglobulinemia 16 | 765
cystic fibrosis 16 | 1,696
Amyotrophic lateral sclerosis 15 | 451
Atopic dermatitis 15 | 952
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Parkinson's disease 15 | 392
Poor school performance 15 | 645
Short stature 15 | 531
acute myeloid leukemia 15 | 783
gastric carcinoma 15 | 807
hepatocellular carcinoma 15 | 547
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Schizophrenia 14 | 1,160
active Crohn's disease 14 | 922
cutaneous lupus erythematosus 14 | 1,057
non primary Sjogren syndrome sicca 14 | 891
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Prostatic Neoplasms 13 | 495
aldosterone-producing adenoma 13 | 665
nasopharyngeal carcinoma 13 | 1,058
Liver Cirrhosis, Experimental 12 | 769
Alzheimer's disease 11 | 658
Multiple Sclerosis 11 | 540
Muscle hypotonia 11 | 571
Neurodegenerative disease 11 | 414
active ulcerative colitis 11 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
pancreatic carcinoma 11 | 562
primary Sjogren syndrome 11 | 735
Cryptorchidism 10 | 296
Duchenne muscular dystrophy 10 | 601
Epilepsy 10 | 792
Kidney disease 10 | 430
Liver cancer 10 | 604
esophageal adenocarcinoma 10 | 737
gastric cancer 10 | 459
progressive supranuclear palsy 10 | 676
sonic hedgehog group medulloblastoma 10 | 467
Bipolar Disorder 9 | 666
Depressed nasal bridge 9 | 195
Seizures 9 | 596

Tissue

Endocrine System 341 | 18,159
Digestive Tract 334 | 17,369
Skin and soft tissues 333 | 17,230
Female tissues 332 | 17,400
Male tissues 332 | 17,142
Nervous System 332 | 16,725
Liver and Pancreas 330 | 16,750
Urinary Tract 328 | 16,678
Blood and immune system 327 | 16,909
Respiratory system 327 | 16,393
Cardiovascular System 325 | 15,192

Target Family

Non-IDG 229 | 12,091
Enzyme 98 | 4,145
Transcription Factor 9 | 1,400
Epigenetic 7 | 242
Kinase 4 | 634

GO Process

protein ubiquitination 347 | 347
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
BTB/POZ domain-containing protein 18 BTBD18 Tdark Non-IDG -0.42597 2.79 11
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
WW domain-containing adapter protein with coiled-coil WAC Tbio Non-IDG -1.93384 84.9 87
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81
E3 ubiquitin-protein ligase DTX1 DTX1 Tbio Enzyme -2.07595 115.2 134
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Ras-related protein Rab-40A RAB40A Tdark Non-IDG -0.72564 4.56 104
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53