Development Level

Tbio 170 | 10,625
Tdark 73 | 7,003
Tchem 15 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, incomple... 13 | 260
abnormal behavior 11 | 226
decreased lean body mass 9 | 195
decreased grip strength 8 | 123
decreased bone mineral density 7 | 126
increased mean corpuscular vol... 7 | 91
increased or absent threshold ... 7 | 128
abnormal bone structure 6 | 131
decreased bone mineral content 6 | 157
abnormal bone mineralization 5 | 55
decreased body weight 4 | 174
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased heart weight 4 | 44
decreased rib number 4 | 59
decreased startle reflex 4 | 48
decreased total body fat amoun... 4 | 186
hyperactivity 4 | 108
hypoactivity 4 | 89
preweaning lethality, complete... 4 | 633
abnormal tooth morphology 3 | 24
decreased circulating choleste... 3 | 85
decreased prepulse inhibition 3 | 52
embryonic lethality prior to t... 3 | 187
increased effector memory CD4-... 3 | 15
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal heart left ventricle ... 2 | 20
abnormal retina morphology 2 | 100
abnormal retinal blood vessel ... 2 | 18
abnormal snout morphology 2 | 18
decreased B cell number 2 | 30
decreased CD4-positive, alpha ... 2 | 19
decreased circulating fructosa... 2 | 31
decreased circulating iron lev... 2 | 25
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased heart rate 2 | 10
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased vertical activity 2 | 22
enlarged heart 2 | 111
female infertility 2 | 34
increased NK cell number 2 | 19
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased effector memory CD8-... 2 | 14
increased fasted circulating g... 2 | 68
increased heart rate 2 | 17
increased heart weight 2 | 37
increased monocyte cell number 2 | 27
increased red blood cell distr... 2 | 21
male infertility 2 | 62
abnormal defecation 1 | 1
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased cardiac muscle contr... 1 | 5
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased mean corpuscular vol... 1 | 50
decreased red blood cell distr... 1 | 11
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased eosinophil cell numb... 1 | 9
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
straub tail 1 | 26
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 149 | 8,484
osteosarcoma 127 | 7,933
medulloblastoma, large-cell 104 | 6,234
glioblastoma 92 | 5,572
atypical teratoid / rhabdoid tumor 84 | 4,369
psoriasis 82 | 6,685
lung cancer 60 | 4,466
malignant mesothelioma 50 | 3,162
primitive neuroectodermal tumor 50 | 3,031
Breast cancer 49 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 49 | 3,289
pilocytic astrocytoma 49 | 3,086
ependymoma 46 | 2,514
oligodendroglioma 45 | 2,849
astrocytic glioma 41 | 2,241
pediatric high grade glioma 41 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
subependymal giant cell astrocytoma 37 | 2,287
Cancer 36 | 2,346
Carcinoma 36 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,956
invasive ductal carcinoma 35 | 2,950
adult high grade glioma 32 | 2,148
non-small cell lung cancer 32 | 2,798
medulloblastoma 31 | 1,524
Multiple myeloma 30 | 1,327
group 3 medulloblastoma 30 | 2,254
group 4 medulloblastoma 30 | 1,875
pancreatic cancer 29 | 2,300
ulcerative colitis 29 | 2,087
lung adenocarcinoma 28 | 2,713
Pick disease 27 | 1,893
adrenocortical carcinoma 25 | 1,427
lung carcinoma 25 | 2,844
spina bifida 25 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
juvenile dermatomyositis 22 | 1,189
pituitary cancer 22 | 1,972
tuberculosis and treatment for 6 months 22 | 686
Rheumatoid Arthritis 21 | 1,160
acute quadriplegic myopathy 19 | 1,157
breast carcinoma 19 | 1,614
interstitial cystitis 19 | 2,299
sonic hedgehog group medulloblastoma 19 | 1,482
diabetes mellitus 18 | 1,663
posterior fossa group A ependymoma 18 | 1,511
tuberculosis 18 | 1,557
ductal carcinoma in situ 16 | 1,745
posterior fossa group B ependymoma 15 | 1,530
colon cancer 14 | 1,475
Parkinson's disease 13 | 364
active Crohn's disease 13 | 918
astrocytoma 13 | 1,493
atypical teratoid/rhabdoid tumor 13 | 1,095
dermatomyositis 13 | 933
hepatocellular carcinoma 13 | 532
Amyotrophic Lateral Sclerosis 12 | 431
Atopic dermatitis 12 | 944
Waldenstrons macroglobulinemia 12 | 765
aldosterone-producing adenoma 12 | 664
cystic fibrosis 12 | 1,665
gastric carcinoma 12 | 832
non primary Sjogren syndrome sicca 11 | 840
primary pancreatic ductal adenocarcinoma 11 | 1,271
Intellectual disability 10 | 573
cutaneous lupus erythematosus 10 | 1,056
pancreatic carcinoma 10 | 567
primary Sjogren syndrome 10 | 789
Mammary Neoplasms 9 | 410
Neurodegenerative disease 9 | 383
Prostatic Neoplasms 9 | 471
acute myeloid leukemia 9 | 780
Multiple Sclerosis 8 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
esophageal adenocarcinoma 8 | 737
gastric cancer 8 | 430
Alzheimer's disease 7 | 644
Obesity 7 | 616
glioblastoma multiforme 7 | 347
nasopharyngeal carcinoma 7 | 1,056
Duchenne muscular dystrophy 6 | 602
Hypertension 6 | 287
Kidney disease 6 | 396
inflammatory breast cancer 6 | 404
progressive supranuclear palsy 6 | 674
sarcoidosis 6 | 358
tuberculosis and treatment for 3 months 6 | 327
Chronic obstructive pulmonary disease 5 | 146
Down syndrome 5 | 548
Heart disease 5 | 279
IGA Glomerulonephritis 5 | 454
Pseudohypoaldosteronism 5 | 22
Renal Cell Carcinoma 5 | 199
Vascular disease 5 | 281
active ulcerative colitis 5 | 477
interstitial lung disease 5 | 291
Endometriosis 4 | 535
Prostate cancer 4 | 172
chronic rhinosinusitis 4 | 512
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Nervous System 258 | 18,561
Digestive Tract 257 | 18,473
Female tissues 257 | 18,647
Urinary Tract 257 | 18,444
Cardiovascular System 256 | 17,958
Liver and Pancreas 256 | 18,136
Skin and soft tissues 256 | 18,115
Blood and immune system 255 | 17,995
Endocrine System 255 | 18,512
Male tissues 255 | 17,969
Respiratory system 254 | 17,484

Target Family

Non-IDG 162 | 11,971
Enzyme 82 | 4,146
Transcription Factor 8 | 1,400
Epigenetic 5 | 242
Kinase 3 | 634

GO Process

protein ubiquitination 260 | 260
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
Kelch-like protein 23 KLHL23 Tdark Non-IDG -0.01424 1.64 48
Kelch-like protein 10 KLHL10 Tdark Non-IDG -0.62839 4.48 35
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Kelch-like protein 26 KLHL26 Tdark Non-IDG 0.60 0.08 76
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 KCTD13 Tbio Non-IDG -0.85155 7.65 69