Development Level

Tbio 264 | 11,445
Tdark 68 | 6,588
Tchem 11 | 1,598
Tclin 5 | 613

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 16 | 499
decreased bone mineral content 8 | 151
embryonic lethality prior to t... 7 | 278
abnormal behavior 6 | 298
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
decreased bone mineral density 6 | 126
decreased total body fat amoun... 6 | 207
embryonic lethality prior to o... 6 | 239
increased mean corpuscular hem... 6 | 96
abnormal retina morphology 5 | 71
cataract 5 | 92
decreased red blood cell distr... 5 | 41
hyperactivity 5 | 148
increased circulating alkaline... 5 | 122
abnormal lens morphology 4 | 81
decreased caudal vertebrae num... 4 | 53
decreased circulating glucose ... 4 | 126
decreased circulating triglyce... 4 | 79
decreased grip strength 4 | 116
decreased mean corpuscular hem... 4 | 50
decreased vertical activity 4 | 208
increased bone mineral content 4 | 108
increased circulating HDL chol... 4 | 80
increased lean body mass 4 | 172
increased mean corpuscular vol... 4 | 92
increased prepulse inhibition 4 | 32
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
thrombocytopenia 4 | 56
abnormal joint morphology 3 | 23
absent pinna reflex 3 | 23
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased leukocyte cell numbe... 3 | 73
edema 3 | 59
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased circulating serum al... 3 | 22
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 36
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal iris morphology 2 | 13
abnormal kidney morphology 2 | 65
abnormal limb morphology 2 | 13
abnormal optic disc morphology 2 | 10
abnormal radius morphology 2 | 8
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal tail morphology 2 | 25
abnormal thoracic cage shape 2 | 3
abnormal ulna morphology 2 | 8
abnormal vertebrae morphology 2 | 18
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased total retina thickne... 2 | 17
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased anti-nuclear antigen... 2 | 19
increased circulating LDL chol... 2 | 13
increased circulating fructosa... 2 | 13
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased startle reflex 2 | 112
microphthalmia 2 | 26
pallor 2 | 34
prenatal lethality 2 | 28
syndactyly 2 | 23
abnormal body wall morphology 1 | 9
abnormal retinal inner nuclear... 1 | 8
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
tremors 1 | 39
vertebral fusion 1 | 23

Disease

ovarian cancer 213 | 8,520
Carcinoma 191 | 11,493
osteosarcoma 158 | 7,950
medulloblastoma, large-cell 145 | 6,241
glioblastoma 137 | 5,792
psoriasis 123 | 6,694
atypical teratoid / rhabdoid tumor 109 | 5,112
ependymoma 105 | 4,679
lung cancer 86 | 4,740
adult high grade glioma 82 | 3,801
group 3 medulloblastoma 79 | 4,104
Astrocytoma, Pilocytic 73 | 3,081
Breast cancer 73 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 64 | 2,955
astrocytic glioma 63 | 2,597
malignant mesothelioma 63 | 3,232
primitive neuroectodermal tumor 62 | 3,035
oligodendroglioma 60 | 2,850
invasive ductal carcinoma 59 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,989
lung carcinoma 56 | 2,843
non-small cell lung cancer 55 | 2,890
Kidney cancer 54 | 2,613
subependymal giant cell astrocytoma 54 | 2,287
tuberculosis 52 | 2,010
Pick disease 46 | 1,894
lung adenocarcinoma 45 | 2,716
group 4 medulloblastoma 40 | 1,855
breast carcinoma 39 | 1,638
diabetes mellitus 37 | 1,728
pancreatic cancer 37 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
ulcerative colitis 37 | 1,819
Multiple myeloma 36 | 1,332
interstitial cystitis 36 | 2,312
juvenile dermatomyositis 36 | 1,187
pituitary cancer 33 | 1,972
Autosomal recessive predisposition 31 | 1,442
astrocytoma 31 | 1,146
Cancer 29 | 2,499
acute quadriplegic myopathy 29 | 1,158
ductal carcinoma in situ 29 | 1,745
Intellectual disability 28 | 1,016
colon cancer 27 | 1,478
adrenocortical carcinoma 26 | 1,428
dermatomyositis 24 | 966
pediatric high grade glioma 24 | 1,064
Rheumatoid arthritis 23 | 1,191
spina bifida 22 | 1,074
active Crohn's disease 21 | 922
active ulcerative colitis 21 | 764
cutaneous lupus erythematosus 21 | 1,057
non primary Sjogren syndrome sicca 21 | 891
progressive supranuclear palsy 21 | 676
acute myeloid leukemia 20 | 783
cystic fibrosis 20 | 1,696
primary pancreatic ductal adenocarcinoma 20 | 1,109
Waldenstrons macroglobulinemia 18 | 765
Schizophrenia 17 | 1,160
medulloblastoma 17 | 720
Cognitive delay 16 | 608
Dull intelligence 16 | 645
Global developmental delay 16 | 608
Liver cancer 16 | 604
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental and motor retardation 16 | 608
Mental deficiency 16 | 645
Poor school performance 16 | 645
Muscle hypotonia 15 | 571
Obesity 15 | 678
Atopic dermatitis 14 | 952
Liver Cirrhosis, Experimental 14 | 769
aldosterone-producing adenoma 14 | 665
pancreatic carcinoma 14 | 562
Neurodegenerative disease 13 | 414
esophageal adenocarcinoma 13 | 737
Alzheimer's disease 12 | 658
Bipolar Disorder 12 | 666
Duchenne muscular dystrophy 12 | 601
Epilepsy 12 | 792
Melanoma 12 | 711
Short stature 12 | 531
Parkinson's disease 11 | 392
gastric carcinoma 11 | 807
nasopharyngeal carcinoma 11 | 1,058
Amyotrophic lateral sclerosis 10 | 451
Cerebral atrophy 10 | 178
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
hereditary spastic paraplegia 10 | 318
primary Sjogren syndrome 10 | 735
Acquired metabolic disease 9 | 336
Bardet-Biedl syndrome 9 | 51
Multiple Sclerosis 9 | 540
Seizures 9 | 596
Skin cancer 9 | 469
head and neck cancer and chronic obstructive pulmonary disease 9 | 239
hepatocellular carcinoma 9 | 547
tuberculosis and treatment for 6 months 9 | 409

Tissue

Endocrine System 346 | 18,159
Female tissues 346 | 17,400
Skin and soft tissues 346 | 17,230
Digestive Tract 345 | 17,369
Liver and Pancreas 345 | 16,750
Male tissues 345 | 17,142
Urinary Tract 345 | 16,678
Nervous System 344 | 16,725
Blood and immune system 342 | 16,909
Respiratory system 341 | 16,393
Cardiovascular System 329 | 15,192

Target Family

Non-IDG 264 | 12,091
Enzyme 70 | 4,145
Transporter 7 | 473
GPCR 2 | 408
Ion Channel 2 | 344
Transcription Factor 2 | 1,400
Kinase 1 | 634

GO Process

protein transport 348 | 348
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Ras-related protein Rab-20 RAB20 Tbio Enzyme -0.97781 11.5 171
Calcium-dependent secretion activator 2 CADPS2 Tbio Non-IDG -1.18033 15.0 36
Protein spire homolog 2 SPIRE2 Tbio Non-IDG -0.76971 5.22 91
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
DnaJ homolog subfamily C member 15 DNAJC15 Tbio Non-IDG -1.67016 50.2 31
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Extracellular matrix protein FRAS1 FRAS1 Tbio Non-IDG -1.51346 36.5 22