Development Level

Tbio 25 | 11,445
Tdark 6 | 6,588
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
hyperactivity 2 | 148
increased circulating bilirubi... 2 | 16
abnormal adrenal gland morphol... 1 | 1
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal thymus morphology 1 | 7
absent startle reflex 1 | 24
aorta dilation 1 | 3
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
hypoactivity 1 | 132
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prolonged QT interval 1 | 38
shortened QT interval 1 | 4
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small thymus 1 | 16
thrombocytosis 1 | 27

Disease

ovarian cancer 18 | 8,520
lung cancer 14 | 4,740
osteosarcoma 11 | 7,950
Carcinoma 10 | 11,493
Multiple myeloma 9 | 1,332
medulloblastoma, large-cell 8 | 6,241
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
Deafness dystonia syndrome 5 | 21
Dystonia 5 | 164
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
Astrocytoma, Pilocytic 4 | 3,081
Barth syndrome 4 | 23
Breast cancer 4 | 3,578
Rheumatoid arthritis 4 | 1,191
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Neurodegenerative disease 3 | 414
Optic Atrophy 3 | 242
Pick disease 3 | 1,894
breast carcinoma 3 | 1,638
group 3 medulloblastoma 3 | 4,104
medulloblastoma 3 | 720
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Acquired scoliosis 2 | 281
Adenocarcinoma of lung 2 | 142
Arthralgia 2 | 90
Axonal degeneration/regeneration 2 | 7
Babinski Reflex 2 | 100
Cancer 2 | 2,499
Charcot-Marie-Tooth disease 2 | 62
Congenital clubfoot 2 | 109
Congenital pes cavus 2 | 88
Contracture 2 | 96
Contracture of joint 2 | 93
Curvature of spine 2 | 282
Decreased motor NCV 2 | 22
Decreased number of large and small myelinated fibers 2 | 20
Decreased tendon reflex 2 | 122
Disease Models, Animal 2 | 155
Distal amyotrophy 2 | 51
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Foot dorsiflexor weakness 2 | 27
Foot-drop 2 | 27
Gait, Drop Foot 2 | 24
Hammer Toe 2 | 23
Hoarse voice due to vocal cord paresis 2 | 3
Infantile onset 2 | 238
Muscle weakness of limb 2 | 21
Neuropathy 2 | 261
Onion bulb formation 2 | 19
Paresthesia 2 | 32
Partial Paralysis (Paresis) Vocal Cords 2 | 3
Polyneuropathy 2 | 64
Proximal muscle weakness 2 | 47
Proximal neurogenic muscle weakness 2 | 47
Reflex, Deep Tendon, Absent 2 | 92
Slow progression 2 | 89
Vocal cord paresis in severe cases 2 | 3
Waldenstrons macroglobulinemia 2 | 765
Weakness of vocal cord 2 | 3
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Axonal regeneration 1 | 3
Decreased circulating ACTH level 1 | 12
Decreased fertility in females 1 | 20
Hypertrophic nerve changes 1 | 5
Joint swelling 1 | 26
Large hand 1 | 18
Myocardial Perfusion Imaging Adjunct 1 | 25
Platelet Aggregation Inhibition 1 | 22
Prevention of Cerebral Thrombosis 1 | 29
Rosacea 1 | 25
Spinal canal stenosis 1 | 12
menstrual periods stopped for over 6 months 1 | 13

Tissue

Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 12 | 4,145
Transporter 1 | 473

GO Process

protein targeting to mitochond... 33 | 33
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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