Development Level

Tbio 5 | 11,178
Tdark 4 | 6,569
Tchem 1 | 1,885

IMPC Phenotype

decreased basophil cell number 1 | 16
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
preweaning lethality, complete... 1 | 979

Disease

ovarian cancer 7 | 8,297
Multiple myeloma 5 | 1,296
osteosarcoma 4 | 7,766
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
Carcinoma 3 | 11,192
Breast cancer 2 | 3,469
Congenital disorder of glycosylation 2 | 54
Craniofacial Abnormalities 2 | 141
Isolated growth hormone deficiency 2 | 30
Pituitary hypoplasia 2 | 19
Waldenstrons macroglobulinemia 2 | 742
adult high grade glioma 2 | 3,701
atypical teratoid / rhabdoid tumor 2 | 4,971
dermatomyositis 2 | 941
glioblastoma 2 | 5,635
group 4 medulloblastoma 2 | 1,806
invasive ductal carcinoma 2 | 2,867
medulloblastoma, large-cell 2 | 6,086
pituitary cancer 2 | 1,915
primary pancreatic ductal adenocarcinoma 2 | 1,071
psoriasis 2 | 6,514
ulcerative colitis 2 | 1,765
Antithrombin III deficiency 1 | 14
Arsenic Poisoning 1 | 60
Barrett's esophagus 1 | 173
Bone cancer 1 | 15
Bulging forehead 1 | 64
Cardiomyopathies 1 | 109
Cataract 8 multiple types 1 | 33
Colorectal Neoplasms 1 | 235
Concave bridge of nose 1 | 191
Contracture 1 | 95
Contracture of joint 1 | 92
Cystic kidney 1 | 30
Decreased tendon reflex 1 | 121
Depressed nasal bridge 1 | 191
Depressed nasal root/bridge 1 | 191
Dermatologic disorders 1 | 88
DiGeorge syndrome 1 | 46
Diarrhea 1 | 245
Elevated hepatic transaminases 1 | 79
Epilepsy 1 | 775
Esotropia 1 | 31
Exocrine pancreatic insufficiency 1 | 30
Factor XI Deficiency 1 | 8
Failure to gain weight 1 | 359
Fibrosis, Liver 1 | 32
Flexion contracture 1 | 92
Flexion contractures of joints 1 | 92
Galactosemia 1 | 19
Generalized osteopenia 1 | 94
Hepatic enzyme increased 1 | 79
Hepatomegaly 1 | 280
Hyperkyphosis 1 | 109
Hypoalbuminemia 1 | 24
Hypocholesterolemia 1 | 6
Hypothyroidism 1 | 115
IgG Deficiency 1 | 22
Immunoglobulin A deficiency (disorder) 1 | 19
Increased number of platelets 1 | 14
Isoelectric focusing of serum transferrin consistent with CDG type I 1 | 10
Kyphosis deformity of spine 1 | 112
Large auricle 1 | 85
Large dysplastic ears 1 | 85
Large pinnae 1 | 85
Large prominent ears 1 | 85
Large protruding ears 1 | 85
Large, floppy ears 1 | 85
Liver Dysfunction 1 | 97
Liver enzymes abnormal 1 | 79
Liver function test increased 1 | 79
Liver function tests abnormal finding 1 | 79
Macrotia 1 | 85
Muscle Weakness 1 | 168
Myopathy 1 | 185
Nephrotic Syndrome 1 | 76
Osteopenia 1 | 94
Ovarian Failure, Premature 1 | 8
Pediatric failure to thrive 1 | 359
Peripheral Neuropathy 1 | 131
Polycystic ovary syndrome 1 | 348
Polyneuropathy 1 | 63
Primary hypogonadism 1 | 35
Prominent forehead 1 | 64
Proteinuria 1 | 143
Renal cyst 1 | 30
Seizures 1 | 584
Shwachman-Diamond syndrome 1 | 17
Skin Diseases 1 | 66
Spinocerebellar ataxia type 2 1 | 23
Steatohepatitis 1 | 44
Subclinical abnormal liver function tests 1 | 79
Thin upper lip vermilion 1 | 67
Thrombocytosis 1 | 36
Transaminases increased 1 | 79
Type 2 diabetes mellitus 1 | 268
Vomiting 1 | 116
Yellow fever 1 | 16
active Crohn's disease 1 | 882
tuberculosis and treatment for 3 months 1 | 175

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 5 | 4,145
Non-IDG 5 | 12,091

GO Process

protein targeting to ER 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
Signal recognition particle 14 kDa protein SRP14 Tbio Non-IDG -1.25810 14.5 106
Signal recognition particle 54 kDa protein SRP54 Tbio Non-IDG -2.15322 140.3 140
Phosphomannomutase 2 PMM2 Tchem Enzyme -2.12990 128.2 153
Signal peptidase complex subunit 2 SPCS2 Tdark Enzyme -0.26503 1.68 51
Signal peptidase complex subunit 3 SPCS3 Tdark Enzyme -0.52720 4.04 50
Signal recognition particle subunit SRP68 SRP68 Tbio Non-IDG -1.13992 13.4 83
Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Tbio Non-IDG -2.46663 293.5 120
Protein transport protein Sec61 subunit gamma SEC61G Tdark Non-IDG -0.37085 2.28 35
Phosphomannomutase 1 PMM1 Tbio Enzyme -1.61681 38.9 50