Development Level

Tbio 26 | 11,445
Tchem 22 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 3 | 220
abnormal behavior 2 | 298
abnormal limb morphology 2 | 13
abnormal tail morphology 2 | 25
embryonic lethality prior to t... 2 | 278
hemorrhage 2 | 23
abnormal body wall morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal limb bud morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cataract 1 | 92
cleft palate 1 | 8
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hyperactivity 1 | 148
increased body weight 1 | 25
increased circulating sodium l... 1 | 71
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 37 | 11,493
ovarian cancer 34 | 8,520
osteosarcoma 29 | 7,950
glioblastoma 21 | 5,792
medulloblastoma, large-cell 21 | 6,241
Cancer 19 | 2,499
psoriasis 19 | 6,694
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
invasive ductal carcinoma 17 | 2,951
malignant mesothelioma 17 | 3,232
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 16 | 4,679
lung cancer 14 | 4,740
Alzheimer's disease 13 | 658
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
non-small cell lung cancer 13 | 2,890
pancreatic cancer 13 | 2,398
adult high grade glioma 12 | 3,801
group 3 medulloblastoma 12 | 4,104
Astrocytoma, Pilocytic 11 | 3,081
cystic fibrosis 11 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung adenocarcinoma 11 | 2,716
lung carcinoma 11 | 2,843
oligodendroglioma 11 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Breast cancer 10 | 3,578
Kidney cancer 10 | 2,613
interstitial cystitis 9 | 2,312
pituitary cancer 9 | 1,972
ulcerative colitis 9 | 1,819
Autosomal recessive predisposition 8 | 1,442
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
primitive neuroectodermal tumor 8 | 3,035
Cerebrovascular disease 7 | 238
Intellectual disability 7 | 1,016
adrenocortical carcinoma 7 | 1,428
breast carcinoma 7 | 1,638
primary pancreatic ductal adenocarcinoma 7 | 1,109
subependymal giant cell astrocytoma 7 | 2,287
Dementia 6 | 175
Hypertension 6 | 396
Neurodegenerative disease 6 | 414
colon cancer 6 | 1,478
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
pediatric high grade glioma 6 | 1,064
Amyotrophic lateral sclerosis 5 | 451
Atherosclerosis 5 | 291
Atopic dermatitis 5 | 952
Ciliopathy 5 | 71
Epilepsy 5 | 792
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
Polydactyly 5 | 107
Schizophrenia 5 | 1,160
Vascular disease 5 | 319
progressive supranuclear palsy 5 | 676
tuberculosis 5 | 2,010
Alzheimer Disease 4 | 83
Amyloidosis 4 | 67
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Breast Neoplasms 4 | 445
Congenital hypoplasia of penis 4 | 176
Dull intelligence 4 | 645
Frontotemporal dementia 4 | 51
Gastrointestinal Stromal Tumors 4 | 48
Highly variable severity 4 | 157
Low intelligence 4 | 645
Mammary Neoplasms 4 | 425
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Variable expressivity 4 | 157
atypical teratoid/rhabdoid tumor 4 | 357
chronic rhinosinusitis 4 | 512
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
medulloblastoma 4 | 720
nasopharyngeal carcinoma 4 | 1,058
posterior fossa group A ependymoma 4 | 468
spina bifida 4 | 1,074
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Endometriosis 3 | 540
Hypersensitivity reaction type II disease 3 | 253
Mental Depression 3 | 333
Ventricular Septal Defects 3 | 119
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic carcinoma 3 | 562
periodontitis 3 | 293

Tissue

Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678
Blood and immune system 50 | 16,909
Male tissues 50 | 17,142
Nervous System 50 | 16,725
Respiratory system 50 | 16,393
Cardiovascular System 48 | 15,192

Target Family

Enzyme 37 | 4,145
Non-IDG 11 | 12,091
Ion Channel 1 | 344
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Process

protein processing 51 | 51
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rhomboid-related protein 2 RHBDL2 Tbio Enzyme -0.71201 6.19 56
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100
AFG3-like protein 2 AFG3L2 Tbio Enzyme -1.58716 39.9 164
Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 Tbio Enzyme -1.46124 30.0 217
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84761 677.3 204
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.75603 4.50 45
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Cathepsin S CTSS Tchem Enzyme -3.31099 1955.9 291