Development Level

Tchem 34 | 1,890
Tbio 28 | 10,625
Tdark 4 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
preweaning lethality, incomple... 4 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal limb bud morphology 2 | 15
abnormal limb morphology 2 | 7
abnormal retinal pigmentation 2 | 61
abnormal tail morphology 2 | 17
decreased body weight 2 | 174
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
hemorrhage 2 | 12
abnormal body wall morphology 1 | 7
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal facial morphology 1 | 9
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal snout morphology 1 | 18
abnormal vibrissa morphology 1 | 17
brachydactyly 1 | 2
cleft palate 1 | 6
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased CD11b-low dendritic ... 1 | 3
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating glycerol... 1 | 19
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased pro-B cell number 1 | 2
decreased total body fat amoun... 1 | 186
edema 1 | 11
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hydrops fetalis 1 | 22
hyperactivity 1 | 108
increased CD11b-high dendritic... 1 | 5
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased pro-B cell number 1 | 1
increased total body fat amoun... 1 | 57
oligodactyly 1 | 14
respiratory system phenotype 1 | 2

Disease

osteosarcoma 39 | 7,933
ovarian cancer 39 | 8,484
psoriasis 26 | 6,685
medulloblastoma, large-cell 24 | 6,234
Cancer 20 | 2,346
lung cancer 20 | 4,466
glioblastoma 19 | 5,572
invasive ductal carcinoma 19 | 2,950
malignant mesothelioma 18 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
lung adenocarcinoma 16 | 2,713
non-small cell lung cancer 16 | 2,798
pancreatic cancer 15 | 2,300
atypical teratoid / rhabdoid tumor 14 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
lung carcinoma 14 | 2,844
Alzheimer's disease 13 | 644
cystic fibrosis 13 | 1,665
ependymoma 13 | 2,514
pilocytic astrocytoma 13 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
oligodendroglioma 12 | 2,849
Breast cancer 11 | 3,094
interstitial cystitis 11 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
pediatric high grade glioma 11 | 2,712
ulcerative colitis 11 | 2,087
adult high grade glioma 10 | 2,148
cutaneous lupus erythematosus 10 | 1,056
Atopic dermatitis 9 | 944
Carcinoma 9 | 2,147
breast carcinoma 9 | 1,614
diabetes mellitus 9 | 1,663
pituitary cancer 9 | 1,972
Multiple myeloma 8 | 1,327
Pick disease 8 | 1,893
atypical teratoid/rhabdoid tumor 8 | 1,095
juvenile dermatomyositis 8 | 1,189
primitive neuroectodermal tumor 8 | 3,031
subependymal giant cell astrocytoma 8 | 2,287
Neurodegenerative disease 7 | 383
adrenocortical carcinoma 7 | 1,427
colon cancer 7 | 1,475
group 3 medulloblastoma 7 | 2,254
posterior fossa group B ependymoma 7 | 1,530
primary pancreatic ductal adenocarcinoma 7 | 1,271
IGA Glomerulonephritis 6 | 454
Vascular disease 6 | 281
astrocytic glioma 6 | 2,241
group 4 medulloblastoma 6 | 1,875
medulloblastoma 6 | 1,524
nasopharyngeal carcinoma 6 | 1,056
progressive supranuclear palsy 6 | 674
tuberculosis 6 | 1,557
Atherosclerosis 5 | 275
Cerebrovascular disease 5 | 231
Hypertension 5 | 287
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 918
ductal carcinoma in situ 5 | 1,745
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
posterior fossa group A ependymoma 5 | 1,511
sonic hedgehog group medulloblastoma 5 | 1,482
Amyloidosis 4 | 68
Arthritis 4 | 248
Dementia 4 | 129
Down syndrome 4 | 548
Frontotemporal dementia 4 | 41
Hidradenitis suppurativa 4 | 12
Kidney disease 4 | 396
Mammary Neoplasms 4 | 410
Obesity 4 | 616
Parkinson's disease 4 | 364
Polydactyly 4 | 93
Rheumatoid Arthritis 4 | 1,160
astrocytoma 4 | 1,493
chronic rhinosinusitis 4 | 512
gastric cancer 4 | 430
glioblastoma multiforme 4 | 347
nephrosclerosis 4 | 329
pancreatic carcinoma 4 | 567
primary Sjogren syndrome 4 | 789
spina bifida 4 | 1,064
Cardiomyopathy 3 | 110
Dermatitis 3 | 107
Disseminated intravascular coagulation 3 | 32
Duchenne muscular dystrophy 3 | 602
Endometriosis 3 | 535
Heart disease 3 | 279
Hypersensitivity reaction type II disease 3 | 235
Hypertensive disease 3 | 193
Intellectual disability 3 | 573
Schizophrenia 3 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
dermatomyositis 3 | 933
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 832
mucosa-associated lymphoid tissue lymphoma 3 | 480
periodontitis 3 | 269
tuberculosis and treatment for 6 months 3 | 686

Tissue

Blood and immune system 66 | 17,995
Cardiovascular System 66 | 17,958
Digestive Tract 66 | 18,473
Endocrine System 66 | 18,512
Female tissues 66 | 18,647
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Nervous System 66 | 18,561
Respiratory system 66 | 17,484
Skin and soft tissues 66 | 18,115
Urinary Tract 66 | 18,444

Target Family

Enzyme 52 | 4,146
Non-IDG 11 | 11,971
Ion Channel 1 | 341
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Process

protein processing 66 | 66
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83
Cysteine protease ATG4A ATG4A Tbio Enzyme -0.98696 7.89 199
Peroxisomal leader peptide-processing protease TYSND1 Tbio Enzyme -0.49732 3.53 45
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.45918 3.20 40
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17963 1388.1 188
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
Methionine aminopeptidase 2 METAP2 Tchem Enzyme -1.90718 91.8 157
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.26683 181.8 641
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.59494 38.2 10