Development Level

Tbio 134 | 10,625
Tchem 20 | 1,890
Tdark 20 | 7,003
Tclin 7 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavior 5 | 226
decreased lean body mass 5 | 195
preweaning lethality, incomple... 5 | 260
decreased bone mineral content 4 | 157
decreased startle reflex 3 | 48
hyperactivity 3 | 108
increased or absent threshold ... 3 | 128
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
hypoactivity 2 | 89
increased fasted circulating g... 2 | 68
limb grasping 2 | 35
short tibia 2 | 82
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal forebrain development 1 | 18
abnormal heart left ventricle ... 1 | 20
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal scapula morphology 1 | 3
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive NK T ce... 1 | 4
decreased CD5-positive Ly6C-po... 1 | 4
decreased Ly6C-positive NK T c... 1 | 2
decreased NK T cell number 1 | 28
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating fructosa... 1 | 31
decreased circulating total pr... 1 | 41
decreased fluid intake 1 | 2
decreased food intake 1 | 6
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased memory-marker CD4-ne... 1 | 4
decreased memory-marker CD4-po... 1 | 4
decreased respiratory quotient 1 | 12
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
female infertility 1 | 34
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased KLRG1+ CD8 alpha bet... 1 | 2
increased Ly6C-positive NK T c... 1 | 1
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating triglyce... 1 | 24
increased effector memory CD8-... 1 | 14
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
increased rib number 1 | 41
male infertility 1 | 62
microcephaly 1 | 3
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
shortened QT interval 1 | 4
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 132 | 8,484
osteosarcoma 86 | 7,933
glioblastoma 66 | 5,572
medulloblastoma, large-cell 65 | 6,234
psoriasis 63 | 6,685
lung cancer 62 | 4,466
atypical teratoid / rhabdoid tumor 50 | 4,369
Multiple myeloma 48 | 1,327
Breast cancer 40 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,289
malignant mesothelioma 32 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
Cancer 29 | 2,346
oligodendroglioma 29 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
subependymal giant cell astrocytoma 28 | 2,287
astrocytic glioma 26 | 2,241
group 4 medulloblastoma 26 | 1,875
pilocytic astrocytoma 26 | 3,086
juvenile dermatomyositis 25 | 1,189
primitive neuroectodermal tumor 25 | 3,031
Carcinoma 24 | 2,147
adult high grade glioma 24 | 2,148
dermatomyositis 24 | 933
pediatric high grade glioma 24 | 2,712
Pick disease 23 | 1,893
ependymoma 23 | 2,514
non-small cell lung cancer 23 | 2,798
pancreatic cancer 21 | 2,300
group 3 medulloblastoma 20 | 2,254
invasive ductal carcinoma 19 | 2,950
ulcerative colitis 19 | 2,087
astrocytoma 18 | 1,493
medulloblastoma 18 | 1,524
tuberculosis 18 | 1,557
acute quadriplegic myopathy 17 | 1,157
lung adenocarcinoma 17 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
HIV Infections 16 | 100
pituitary cancer 16 | 1,972
tuberculosis and treatment for 6 months 16 | 686
lung carcinoma 15 | 2,844
spina bifida 15 | 1,064
Waldenstrons macroglobulinemia 14 | 765
primary Sjogren syndrome 13 | 789
acute myeloid leukemia 12 | 780
cutaneous lupus erythematosus 12 | 1,056
primary pancreatic ductal adenocarcinoma 12 | 1,271
Rheumatoid Arthritis 11 | 1,160
diabetes mellitus 11 | 1,663
esophageal adenocarcinoma 11 | 737
interstitial cystitis 11 | 2,299
progressive supranuclear palsy 11 | 674
sonic hedgehog group medulloblastoma 11 | 1,482
adrenocortical carcinoma 10 | 1,427
non primary Sjogren syndrome sicca 10 | 840
posterior fossa group A ependymoma 10 | 1,511
breast carcinoma 9 | 1,614
cystic fibrosis 9 | 1,665
ductal carcinoma in situ 9 | 1,745
IGA Glomerulonephritis 8 | 454
gastric carcinoma 8 | 832
Alzheimer's disease 7 | 644
active Crohn's disease 7 | 918
aldosterone-producing adenoma 7 | 664
colon cancer 7 | 1,475
hepatocellular carcinoma 7 | 532
Atopic dermatitis 6 | 944
Duchenne muscular dystrophy 6 | 602
Intellectual disability 6 | 573
Multiple Sclerosis 6 | 498
atypical teratoid/rhabdoid tumor 6 | 1,095
nasopharyngeal carcinoma 6 | 1,056
sarcoidosis 6 | 358
Amyotrophic Lateral Sclerosis 5 | 431
Mantle cell lymphoma 5 | 18
Neurodegenerative disease 5 | 383
Parkinson's disease 5 | 364
gastric cancer 5 | 430
posterior fossa group B ependymoma 5 | 1,530
systemic lupus erythematosus 5 | 156
Diffuse large B-cell lymphoma 4 | 41
Endometriosis 4 | 535
Male infertility 4 | 170
Mammary Neoplasms 4 | 410
Osteoporosis 4 | 257
Squamous cell carcinoma of esophagus 4 | 82
Stevens-Johnson syndrome 4 | 78
Stomach Neoplasms 4 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
glioblastoma multiforme 4 | 347
tuberculosis and treatment for 3 months 4 | 327
Cockayne syndrome 3 | 54
Colonic Neoplasms 3 | 126
Disease Progression 3 | 125
Down syndrome 3 | 548
Peripheral Neuropathy 3 | 303
Prostatic Neoplasms 3 | 471
chronic rhinosinusitis 3 | 512
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 180 | 17,995
Digestive Tract 180 | 18,473
Endocrine System 180 | 18,512
Female tissues 180 | 18,647
Liver and Pancreas 180 | 18,136
Nervous System 180 | 18,561
Urinary Tract 180 | 18,444
Cardiovascular System 179 | 17,958
Male tissues 179 | 17,969
Skin and soft tissues 179 | 18,115
Respiratory system 178 | 17,484

Target Family

Enzyme 113 | 4,146
Non-IDG 63 | 11,971
Epigenetic 3 | 242
Transcription Factor 2 | 1,400

GO Process

protein polyubiquitination 181 | 181
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apoptosis regulator Bcl-2 BCL2 Tclin Non-IDG -2.14885 123.8 1935
E3 ubiquitin-protein ligase parkin PARK2 Tbio Enzyme -2.95958 955.5 485
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.63770 438.1 349
E3 ubiquitin-protein ligase HUWE1 HUWE1 Tbio Enzyme -2.06884 113.9 106
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.45381 312.7 133
Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Tbio Non-IDG -1.71927 53.7 272