Development Level

Tchem 201 | 1,890
Tbio 84 | 10,625
Tclin 25 | 602
Tdark 10 | 7,003

Collection

Eligible Kinase Proteins 48 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 12 | 260
abnormal embryo size 5 | 112
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
abnormal lens morphology 4 | 73
decreased body length 4 | 108
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
increased circulating iron lev... 4 | 25
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased circulating HDL chol... 3 | 77
decreased circulating glucose ... 3 | 121
decreased fasted circulating g... 3 | 49
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
increased or absent threshold ... 3 | 128
abnormal behavior 2 | 226
abnormal kidney morphology 2 | 30
abnormal lumbar vertebrae morp... 2 | 6
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal spleen morphology 2 | 36
decreased blood urea nitrogen ... 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating glycerol... 2 | 19
decreased circulating iron lev... 2 | 25
decreased circulating magnesiu... 2 | 11
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased hematocrit 2 | 25
decreased leukocyte cell numbe... 2 | 54
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating bilirubi... 2 | 16
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mature B cell number 2 | 12
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased respiratory quotient 2 | 12
male infertility 2 | 62
short tibia 2 | 82
small superior vagus ganglion 2 | 20
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal lung morphology 1 | 15
abnormal neural tube closure 1 | 37
abnormal retinal blood vessel ... 1 | 18
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 2
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased NK cell number 1 | 19
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
long tibia 1 | 13
microphthalmia 1 | 15
premature death 1 | 5

Disease

osteosarcoma 193 | 7,933
ovarian cancer 186 | 8,484
medulloblastoma, large-cell 147 | 6,234
psoriasis 143 | 6,685
glioblastoma 125 | 5,572
Cancer 115 | 2,346
lung cancer 107 | 4,466
atypical teratoid / rhabdoid tumor 101 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
malignant mesothelioma 76 | 3,162
pilocytic astrocytoma 76 | 3,086
primitive neuroectodermal tumor 74 | 3,031
oligodendroglioma 73 | 2,849
Breast cancer 72 | 3,094
non-small cell lung cancer 70 | 2,798
pediatric high grade glioma 70 | 2,712
lung carcinoma 69 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 68 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,988
invasive ductal carcinoma 68 | 2,950
ependymoma 67 | 2,514
Carcinoma 64 | 2,147
lung adenocarcinoma 58 | 2,713
ulcerative colitis 55 | 2,087
interstitial cystitis 53 | 2,299
pancreatic cancer 53 | 2,300
Pick disease 52 | 1,893
cystic fibrosis 49 | 1,665
subependymal giant cell astrocytoma 49 | 2,287
astrocytic glioma 48 | 2,241
astrocytoma 47 | 1,493
group 4 medulloblastoma 45 | 1,875
medulloblastoma 45 | 1,524
diabetes mellitus 43 | 1,663
adult high grade glioma 42 | 2,148
group 3 medulloblastoma 42 | 2,254
tuberculosis 40 | 1,557
adrenocortical carcinoma 39 | 1,427
Renal Cell Carcinoma 38 | 199
ductal carcinoma in situ 37 | 1,745
Rheumatoid Arthritis 36 | 1,160
breast carcinoma 34 | 1,614
juvenile dermatomyositis 34 | 1,189
pituitary cancer 34 | 1,972
posterior fossa group B ependymoma 32 | 1,530
sonic hedgehog group medulloblastoma 32 | 1,482
spina bifida 32 | 1,064
acute quadriplegic myopathy 29 | 1,157
Multiple myeloma 28 | 1,327
cutaneous lupus erythematosus 27 | 1,056
posterior fossa group A ependymoma 27 | 1,511
primary pancreatic ductal adenocarcinoma 27 | 1,271
colon cancer 26 | 1,475
Chronic Myelocytic Leukemia Accelerated Phase 25 | 59
atypical teratoid/rhabdoid tumor 25 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Blastic phase chronic myeloid leukemia 24 | 58
Gastrointestinal stromal tumor 24 | 61
dermatomyositis 24 | 933
Pancreatic Neuroendocrine Tumor 23 | 45
Waldenstrons macroglobulinemia 23 | 765
acute myeloid leukemia 22 | 780
Alzheimer's disease 21 | 644
Down syndrome 21 | 548
primary Sjogren syndrome 21 | 789
Prostatic Neoplasms 20 | 471
Schizophrenia 20 | 501
Atopic dermatitis 19 | 944
Obesity 19 | 616
Parkinson's disease 19 | 364
nasopharyngeal carcinoma 19 | 1,056
Peripheral Neuropathy 18 | 303
Stomach Neoplasms 18 | 282
pancreatic carcinoma 18 | 567
progressive supranuclear palsy 18 | 674
tuberculosis and treatment for 6 months 18 | 686
esophageal adenocarcinoma 17 | 737
gastric carcinoma 17 | 832
IGA Glomerulonephritis 16 | 454
Mammary Neoplasms 16 | 410
Vascular disease 16 | 281
aldosterone-producing adenoma 16 | 664
Colorectal Neoplasms 15 | 217
Intellectual disability 15 | 573
Kidney disease 15 | 396
Lung Neoplasms 15 | 171
non-small cell lung carcinoma 15 | 413
Asthma 14 | 349
Chronic Lymphocytic Leukemia 14 | 242
Chronic phase chronic myeloid leukemia 14 | 45
Hypertension 14 | 287
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
Heart disease 13 | 279
non primary Sjogren syndrome sicca 13 | 840
Arthritis 12 | 248
Epilepsy 12 | 346
Multiple Sclerosis 12 | 498
Neurodegenerative disease 12 | 383
active Crohn's disease 12 | 918

Tissue

Digestive Tract 318 | 18,473
Blood and immune system 317 | 17,995
Endocrine System 317 | 18,512
Liver and Pancreas 317 | 18,136
Male tissues 317 | 17,969
Cardiovascular System 316 | 17,958
Female tissues 316 | 18,647
Nervous System 316 | 18,561
Urinary Tract 316 | 18,444
Skin and soft tissues 311 | 18,115
Respiratory system 310 | 17,484

Target Family

Kinase 261 | 634
Non-IDG 36 | 11,971
Enzyme 13 | 4,146
Transcription Factor 7 | 1,400
GPCR 1 | 406
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

GO Process

protein phosphorylation 320 | 320
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
Mitogen-activated protein kinase kinase kinase MLT MAP3K20 Tchem Kinase -1.14470 13.6 205
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767