Development Level

Tchem 214 | 1,598
Tbio 79 | 11,445
Tclin 30 | 613
Tdark 11 | 6,588

Collection

Kinase: IDG Consortium (Target... 45 | 125
Kinase: IDG Consortium (Comple... 24 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 17 | 499
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 8 | 278
enlarged heart 8 | 210
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
abnormal heart morphology 5 | 162
decreased leukocyte cell numbe... 5 | 73
decreased vertical activity 5 | 208
increased circulating alkaline... 5 | 122
increased or absent threshold ... 5 | 101
abnormal behavior 4 | 298
decreased circulating glucose ... 4 | 126
decreased lymphocyte cell numb... 4 | 83
decreased total body fat amoun... 4 | 207
increased bone mineral content 4 | 108
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased fasted circulating g... 3 | 65
decreased large unstained cell... 3 | 11
decreased lean body mass 3 | 135
decreased mean platelet volume 3 | 25
decreased startle reflex 3 | 75
enlarged spleen 3 | 41
increased blood urea nitrogen ... 3 | 48
increased circulating iron lev... 3 | 30
increased erythrocyte cell num... 3 | 39
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
male infertility 3 | 123
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal urinary bladder morph... 2 | 11
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating glycerol... 2 | 16
decreased circulating iron lev... 2 | 32
decreased circulating magnesiu... 2 | 13
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
edema 2 | 59
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating sodium l... 2 | 71
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
increased startle reflex 2 | 112
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
thrombocytosis 1 | 27

Disease

Carcinoma 278 | 11,493
osteosarcoma 201 | 7,950
ovarian cancer 199 | 8,520
medulloblastoma, large-cell 156 | 6,241
psoriasis 147 | 6,694
glioblastoma 143 | 5,792
atypical teratoid / rhabdoid tumor 130 | 5,112
Cancer 129 | 2,499
lung cancer 122 | 4,740
ependymoma 115 | 4,679
group 3 medulloblastoma 94 | 4,104
adult high grade glioma 90 | 3,801
Kidney cancer 87 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 86 | 3,291
Breast cancer 84 | 3,578
malignant mesothelioma 83 | 3,232
primitive neuroectodermal tumor 80 | 3,035
Astrocytoma, Pilocytic 78 | 3,081
oligodendroglioma 77 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 72 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 72 | 2,989
invasive ductal carcinoma 72 | 2,951
non-small cell lung cancer 72 | 2,890
lung carcinoma 69 | 2,843
astrocytic glioma 62 | 2,597
lung adenocarcinoma 62 | 2,716
pancreatic cancer 62 | 2,398
Pick disease 57 | 1,894
interstitial cystitis 56 | 2,312
subependymal giant cell astrocytoma 54 | 2,287
tuberculosis 52 | 2,010
cystic fibrosis 51 | 1,696
ulcerative colitis 51 | 1,819
group 4 medulloblastoma 48 | 1,855
diabetes mellitus 46 | 1,728
Schizophrenia 43 | 1,160
breast carcinoma 42 | 1,638
Renal Cell Carcinoma 41 | 214
adrenocortical carcinoma 41 | 1,428
astrocytoma 40 | 1,146
ductal carcinoma in situ 40 | 1,745
Rheumatoid arthritis 38 | 1,191
juvenile dermatomyositis 38 | 1,187
Autosomal recessive predisposition 37 | 1,442
pituitary cancer 35 | 1,972
spina bifida 33 | 1,074
Intellectual disability 32 | 1,016
Multiple myeloma 32 | 1,332
colon cancer 31 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
acute quadriplegic myopathy 29 | 1,158
pediatric high grade glioma 29 | 1,064
cutaneous lupus erythematosus 27 | 1,057
primary pancreatic ductal adenocarcinoma 27 | 1,109
Bipolar Disorder 26 | 666
Chronic Myelocytic Leukemia Accelerated Phase 26 | 59
Blastic phase chronic myeloid leukemia 25 | 58
Dull intelligence 25 | 645
Epilepsy 25 | 792
Gastrointestinal stromal tumor 25 | 62
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
dermatomyositis 25 | 966
Alzheimer's disease 24 | 658
Prostatic Neoplasms 24 | 495
Waldenstrons macroglobulinemia 24 | 765
medulloblastoma 24 | 720
Obesity 23 | 678
Pancreatic Neuroendocrine Tumor 23 | 45
acute myeloid leukemia 23 | 783
primary Sjogren syndrome 23 | 735
Liver Cirrhosis, Experimental 22 | 769
Parkinson's disease 22 | 392
nasopharyngeal carcinoma 22 | 1,058
Breast Neoplasms 21 | 445
Hypertensive disease 21 | 292
Atopic dermatitis 20 | 952
Cognitive delay 20 | 608
Down syndrome 20 | 499
Global developmental delay 20 | 608
Mammary Neoplasms 20 | 425
Melanoma 20 | 711
Mental and motor retardation 20 | 608
Stomach Neoplasms 20 | 300
gastric carcinoma 20 | 807
Depressive disorder 19 | 409
Hypertension 19 | 396
Short stature 19 | 531
esophageal adenocarcinoma 19 | 737
progressive supranuclear palsy 18 | 676
Asthma 17 | 385
Chronic Lymphocytic Leukemia 17 | 262
Lung Neoplasms 17 | 232
Seizures 17 | 596
Vascular disease 17 | 319
pancreatic carcinoma 17 | 562
Small head 16 | 374
aldosterone-producing adenoma 16 | 665

Tissue

Endocrine System 329 | 18,159
Skin and soft tissues 329 | 17,230
Digestive Tract 328 | 17,369
Female tissues 327 | 17,400
Male tissues 327 | 17,142
Blood and immune system 325 | 16,909
Nervous System 325 | 16,725
Urinary Tract 325 | 16,678
Liver and Pancreas 324 | 16,750
Respiratory system 323 | 16,393
Cardiovascular System 315 | 15,192

Target Family

Kinase 274 | 634
Non-IDG 36 | 12,091
Enzyme 15 | 4,145
Transcription Factor 6 | 1,400
GPCR 1 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Process

protein phosphorylation 334 | 334
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Serine/threonine-protein kinase MRCK beta CDC42BPB Tbio Kinase -0.59618 3.72 111
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.28897 20.5 123
PAS domain-containing serine/threonine-protein kinase PASK Tbio Kinase -1.01354 12.3 95
Testis-specific serine/threonine-protein kinase 3 TSSK3 Tbio Kinase -0.52985 3.86 47
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336