Development Level

Tbio 31 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

hypoactivity 4 | 132
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
increased fasted circulating g... 2 | 76
increased lymphocyte cell numb... 2 | 32
increased or absent threshold ... 2 | 101
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal iris transilluminatio... 1 | 2
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
anophthalmia 1 | 33
cataract 1 | 92
cornea ulcer 1 | 1
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating triglyce... 1 | 79
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
fused cornea and lens 1 | 5
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
prenatal lethality 1 | 28

Disease

Carcinoma 22 | 11,493
ovarian cancer 21 | 8,520
glioblastoma 16 | 5,792
medulloblastoma, large-cell 16 | 6,241
atypical teratoid / rhabdoid tumor 13 | 5,112
osteosarcoma 13 | 7,950
psoriasis 13 | 6,694
adult high grade glioma 11 | 3,801
ependymoma 10 | 4,679
oligodendroglioma 10 | 2,850
primitive neuroectodermal tumor 9 | 3,035
Astrocytoma, Pilocytic 8 | 3,081
Cancer 8 | 2,499
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung cancer 8 | 4,740
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Breast cancer 6 | 3,578
Kidney cancer 6 | 2,613
Dull intelligence 5 | 645
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Pick disease 5 | 1,894
Poor school performance 5 | 645
Rheumatoid arthritis 5 | 1,191
breast carcinoma 5 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
juvenile dermatomyositis 5 | 1,187
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
Autosomal recessive predisposition 4 | 1,442
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
astrocytoma 4 | 1,146
group 3 medulloblastoma 4 | 4,104
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
spina bifida 4 | 1,074
subependymal giant cell astrocytoma 4 | 2,287
Endometriosis 3 | 540
Hypertension 3 | 396
Leukopenia 3 | 72
Short stature 3 | 531
Small head 3 | 374
Stevens-Johnson syndrome 3 | 92
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
medulloblastoma 3 | 720
pituitary cancer 3 | 1,972
progressive supranuclear palsy 3 | 676
ulcerative colitis 3 | 1,819
Abnormality of retinal pigmentation 2 | 111
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Anemia 2 | 365
Anteverted nostril 2 | 191
Atopic dermatitis 2 | 952
Blepharoptosis 2 | 231
Broad flat nasal bridge 2 | 236
Concave bridge of nose 2 | 195
Congenital Epicanthus 2 | 177
Curvature of spine 2 | 282
Delayed speech and language development 2 | 112
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Hemoglobin low 2 | 124
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperreflexia 2 | 209
Language Delay 2 | 112
Melanoma 2 | 711
Nasal bridge wide 2 | 236
Parkinson's disease 2 | 392
Phenotypic variability 2 | 150
Primary biliary cirrhosis 2 | 51
Retinal pigment epithelial abnormality 2 | 111
Sensorineural Hearing Loss (disorder) 2 | 284
Short palpebral fissure 2 | 38
Speech Delay 2 | 112
Speech impairment 2 | 112
Vasculitis 2 | 80
acute myeloid leukemia 2 | 783
aldosterone-producing adenoma 2 | 665
colon cancer 2 | 1,478
esophageal adenocarcinoma 2 | 737
nasopharyngeal carcinoma 2 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis 2 | 2,010

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 15 | 4,145

GO Process

protein monoubiquitination 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/LRR-repeat protein 2 FBXL2 Tbio Non-IDG -0.89339 8.63 129
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
E3 ubiquitin-protein ligase ZNF598 ZNF598 Tbio Non-IDG -0.43933 2.28 109
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.09204 13.1 165
Ubiquitin-conjugating enzyme E2 R2 UBE2R2 Tbio Non-IDG 0.11 0.74 128
Kelch repeat and BTB domain-containing protein 8 KBTBD8 Tbio Non-IDG -0.04537 1.12 49
Ubiquitin conjugation factor E4 B UBE4B Tbio Non-IDG -1.86207 73.2 141
E3 ubiquitin-protein ligase HUWE1 HUWE1 Tbio Enzyme -2.11897 123.4 121
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167