Development Level

Tbio 9 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal gait 1 | 69
aorta dilation 1 | 3
decreased body weight 1 | 161
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
hypoactivity 1 | 132
increased circulating serum al... 1 | 22
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prolonged QT interval 1 | 38
shortened QT interval 1 | 4

Disease

Carcinoma 8 | 11,493
osteosarcoma 8 | 7,950
ovarian cancer 8 | 8,520
psoriasis 7 | 6,694
medulloblastoma, large-cell 5 | 6,241
glioblastoma 4 | 5,792
Kidney cancer 3 | 2,613
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
Intellectual disability 2 | 1,016
Multiple myeloma 2 | 1,332
Neurodegeneration with brain iron accumulation 5 2 | 9
Neurodegenerative disease 2 | 414
Vici syndrome 2 | 14
colon cancer 2 | 1,478
lung cancer 2 | 4,740
posterior fossa group A ependymoma 2 | 468
ulcerative colitis 2 | 1,819
Abnormal color vision 1 | 31
Abnormal visual evoked potential 1 | 26
Absent speech 1 | 43
Alopecia areata 1 | 41
Anosmia 1 | 22
Arthralgia 1 | 90
Autonomic nervous system disorders 1 | 19
Axonal degeneration/regeneration 1 | 7
Babinski Reflex 1 | 100
Blind spot located at fixation point 1 | 21
Cardiomegaly 1 | 116
Centronuclear myopathy 1 | 27
Cerebral palsy 1 | 40
Charcot-Marie-Tooth disease 1 | 62
Color vision defect 1 | 33
Color vision defect, severe 1 | 31
Common variable immunodeficiency 1 | 101
Congenital pes cavus 1 | 88
Contracture 1 | 96
Contracture of joint 1 | 93
Crohn Disease 1 | 45
Decreased motor NCV 1 | 22
Decreased to absent deep tendon reflexes 1 | 42
Decreased visual acuity, slowly progressive 1 | 13
Degenerative brain disorder 1 | 100
Distal amyotrophy 1 | 51
Distal sensory impairment 1 | 52
Distal sensory impairment of all modalities 1 | 7
Dysautonomia 1 | 20
Dysmetric saccades 1 | 9
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot dorsiflexor weakness 1 | 27
Foot-drop 1 | 27
Frontal release signs 1 | 3
Gait, Drop Foot 1 | 24
Gaucher disease type 1 1 | 180
Hammer Toe 1 | 23
Highly variable severity 1 | 157
Inflammatory Bowel Diseases 1 | 35
Inflammatory bowel disease 5 1 | 14
Insulin Resistance 1 | 72
Joint stiffness 1 | 84
Lipidoses 1 | 19
Lipoidosis 1 | 19
Lipoma 1 | 32
Lumbar lordosis 1 | 35
Mucopolysaccharidosis III 1 | 7
Multiple lipomata 1 | 7
Muscle Rigidity 1 | 49
Muscle weakness of limb 1 | 21
Nerve Degeneration 1 | 121
Neuro-degenerative disease 1 | 43
Neurodegeneration with brain iron accumulation 1 | 20
Neurodegeneration with brain iron accumulation (NBIA) 1 | 2
Neurodegenerative Disorders 1 | 79
Onion bulb formation 1 | 19
Pain 1 | 103
Pallor of optic disc 1 | 39
Paraparesis, Spastic 1 | 16
Paresthesia 1 | 32
Parkinsonian Disorders 1 | 56
Peripheral axonal atrophy 1 | 4
Polyneuropathy 1 | 64
Poor speech 1 | 37
Problems speaking 1 | 37
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Romberg's sign positive 1 | 4
Scotoma, Central 1 | 21
Slow decrease in visual acuity 1 | 13
Slow progression 1 | 89
Spastic Paraplegia, Hereditary 1 | 5
Supratentorial atrophy 1 | 94
Tinnitus 1 | 19
Tremor 1 | 113
Variable expressivity 1 | 157
Vitiligo 1 | 73
X-linked dominant 1 | 57
alcohol-related neurodevelopmental disorder 1 | 13
limb girdle muscular dystrophy 2B 1 | 40
nonverbal 1 | 43

Tissue

Blood and immune system 12 | 16,909
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Cardiovascular System 11 | 15,192

Target Family

Non-IDG 11 | 12,091
Kinase 1 | 634

GO Process

protein localization to pre-au... 12 | 12
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphofurin acidic cluster sorting protein 2 PACS2 Tbio Non-IDG -1.72291 53.9 72
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Trafficking protein particle complex subunit 8 TRAPPC8 Tdark Non-IDG -1.08378 10.2 5
WD repeat domain phosphoinositide-interacting protein 3 WDR45B Tdark Non-IDG -0.10121 1.33 98
Mitofusin-2 MFN2 Tbio Non-IDG -2.68784 484.6 447
Autophagy-related protein 9B ATG9B Tbio Non-IDG 0.00000 142
Autophagy-related protein 16-1 ATG16L1 Tbio Non-IDG -2.26343 183.4 600
Syntaxin-17 STX17 Tbio Non-IDG -1.51185 33.1 109
WD repeat domain phosphoinositide-interacting protein 2 WIPI2 Tbio Non-IDG -1.16004 13.0 195
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.33238 204.8 739