Development Level

Tbio 6 | 11,445

IMPC Phenotype

abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal tail morphology 1 | 25
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased total body fat amoun... 1 | 207
enlarged spleen 1 | 41
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
preweaning lethality, complete... 1 | 979

Disease

Abnormal behavior 5 | 52
Abnormal skeletal development 5 | 60
Abnormality of metabolism/homeostasis 5 | 134
Abnormality of retinal pigmentation 5 | 111
Abnormality of the liver 5 | 21
Abnormality of the palate 5 | 17
Addison Disease 5 | 18
Adrenal cortical hypofunction 5 | 23
Adrenoleukodystrophy, Neonatal 5 | 13
Anteverted nostril 5 | 191
Big calvaria 5 | 147
Bilateral single transverse palmar creases 5 | 34
Blepharoptosis 5 | 231
Broad flat nasal bridge 5 | 236
Byzanthine arch palate 5 | 194
Clouding of corneal stroma 5 | 50
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Corneal Opacity 5 | 53
Death in early childhood 5 | 82
Death in infancy 5 | 82
Decreased to absent deep tendon reflexes 5 | 42
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Developmental regression 5 | 95
Difficulties with night vision 5 | 87
Electroencephalogram abnormal 5 | 101
Elevated levels of phytanic acid 5 | 15
Embryotoxon 5 | 28
Failure to gain weight 5 | 365
Flat back of the head 5 | 26
Flat face 5 | 52
Flat occiput 5 | 26
Global developmental delay, severe 5 | 47
Hepatomegaly 5 | 285
High forehead 5 | 102
Hydronephrosis 5 | 89
Hyperreflexia 5 | 209
Hypertrophy of clitoris 5 | 40
Hypotonia, severe 5 | 33
Icterus 5 | 82
Impaired cognition 5 | 96
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Infantile Refsum Disease (disorder) 5 | 13
Infantile Refsum disease 5 | 23
Liver Failure 5 | 73
Liver diseases 5 | 87
Long narrow head 5 | 75
Loss of developmental milestones 5 | 95
Low Vision 5 | 174
Malabsorption 5 | 82
Malformations of Cortical Development, Group II 5 | 31
Malformed pinnae 5 | 37
Mental deterioration in childhood 5 | 95
Mental impairment 5 | 95
Movement Disorders 5 | 55
Muscle Spasticity 5 | 195
Muscle weakness, progressive 5 | 22
Narrow cranium shape 5 | 75
Narrow head shape 5 | 75
Narrow skull shape 5 | 75
Nasal bridge wide 5 | 236
Neonatal adrenoleukodystrophy 5 | 14
Neurodevelopmental regression 5 | 95
Night Blindness 5 | 101
Osteochondrodysplasias 5 | 72
Pediatric failure to thrive 5 | 365
Penile hypospadias 5 | 106
Peroxisomal disease 5 | 22
Polymicrogyria 5 | 48
Posterior embryotoxon 5 | 28
Premature Birth 5 | 77
Premature birth of newborn 5 | 67
Profound global developmental delay 5 | 17
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Psychomotor retardation, profound 5 | 17
Pyloric Stenosis 5 | 47
Respiratory Insufficiency 5 | 132
Respiratory function loss 5 | 121
Retinal pigment epithelial abnormality 5 | 111
Seizures 5 | 596
Sensorineural Hearing Loss (disorder) 5 | 284
Severe psychomotor retardation 5 | 47
Stippled epiphyses 5 | 28
Strabismus 5 | 270
Tall forehead 5 | 102
Turridolichocephaly 5 | 75
Underdeveloped brows 5 | 38
Underdeveloped supraorbital ridges 5 | 38
Upward slant of palpebral fissure 5 | 75
Very long chain fatty acid accumulation 5 | 13
Visual Impairment 5 | 174
Visual field constriction 5 | 36
Wide anterior fontanel 5 | 44
Zellweger syndrome 5 | 37

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Non-IDG 5 | 12,091
Enzyme 1 | 4,145

GO Process

protein import into peroxisome... 6 | 6
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Peroxisomal targeting signal 1 receptor PEX5 Tbio Non-IDG -2.43126 272.8 138
Peroxisomal biogenesis factor 3 PEX3 Tbio Non-IDG -1.79362 72.7 79
Peroxisome assembly protein 26 PEX26 Tbio Non-IDG -1.04829 11.8 85
Peroxisomal biogenesis factor 19 PEX19 Tbio Non-IDG -2.28877 200.1 264
Ras-related protein Rab-8B RAB8B Tbio Enzyme -0.91719 6.86 179