Development Level

Tbio 19 | 11,445
Tchem 8 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
increased bone mineral density 2 | 72
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
decreased bone mineral density 1 | 126
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
increased bone mineral content 1 | 108
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 22 | 11,493
ovarian cancer 14 | 8,520
Cancer 12 | 2,499
osteosarcoma 12 | 7,950
psoriasis 12 | 6,694
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung cancer 8 | 4,740
lung carcinoma 8 | 2,843
medulloblastoma, large-cell 8 | 6,241
Epilepsy 7 | 792
ependymoma 7 | 4,679
interstitial cystitis 7 | 2,312
lung adenocarcinoma 7 | 2,716
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Seizures 6 | 596
glioblastoma 6 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
cutaneous lupus erythematosus 5 | 1,057
invasive ductal carcinoma 5 | 2,951
ulcerative colitis 5 | 1,819
Depressive disorder 4 | 409
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Pick disease 4 | 1,894
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
adult high grade glioma 4 | 3,801
diabetes mellitus 4 | 1,728
malignant mesothelioma 4 | 3,232
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Asthma 3 | 385
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Autistic Disorder 3 | 364
Autosomal recessive predisposition 3 | 1,442
Cognitive delay 3 | 608
Coronary artery disease 3 | 268
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Hypersensitivity reaction type II disease 3 | 253
Inflammation 3 | 120
Liver Cirrhosis, Experimental 3 | 769
Mental and motor retardation 3 | 608
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Pediatric failure to thrive 3 | 365
Stomach Neoplasms 3 | 300
active Crohn's disease 3 | 922
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
atypical teratoid / rhabdoid tumor 3 | 5,112
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287
Alcoholic Intoxication, Chronic 2 | 289
Amyotrophic lateral sclerosis 2 | 451
Brain Ischemia 2 | 110
Cerebrovascular disease 2 | 238
Cocaine-Related Disorders 2 | 92
Cognition Disorders 2 | 32
Decreased joint mobility 2 | 53
Dementia 2 | 175
Electroencephalogram abnormal 2 | 101
Endometriosis 2 | 540
Huntington's disease 2 | 76
Hyperreflexia 2 | 209
Inflammatory bowel disease 2 | 151
Kidney disease 2 | 430
Mental Depression 2 | 333
Mood Disorders 2 | 184
Myopathy 2 | 185
Parkinson's disease 2 | 392
Strabismus 2 | 270
Vascular disease 2 | 319
Vomiting 2 | 116
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
mucosa-associated lymphoid tissue lymphoma 2 | 484
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Nervous System 29 | 16,725
Skin and soft tissues 29 | 17,230
Male tissues 28 | 17,142
Respiratory system 28 | 16,393
Urinary Tract 28 | 16,678
Cardiovascular System 26 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 7 | 4,145
Ion Channel 3 | 344
Transcription Factor 3 | 1,400
Kinase 1 | 634
Transporter 1 | 473

GO Process

protein homotrimerization 29 | 29
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sigma non-opioid intracellular receptor 1 SIGMAR1 Tclin Non-IDG -2.28907 210.0 143
Serine protease HTRA2, mitochondrial HTRA2 Tbio Enzyme -2.60032 392.5 519
Heat shock factor protein 4 HSF4 Tbio Transcription Factor -2.82845 672.2 263
Mixed lineage kinase domain-like protein MLKL Tchem Kinase -2.75630 549.8 171
Microsomal glutathione S-transferase 1 MGST1 Tbio Enzyme -2.30082 197.5 146
Ataxin-10 ATXN10 Tbio Non-IDG -1.82047 67.3 120
Excitatory amino acid transporter 2 SLC1A2 Tchem Transporter -2.96237 939.6 187
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Polycystic kidney disease 2-like 1 protein PKD2L1 Tchem Ion Channel -1.95186 96.8 100
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605