Development Level

Tbio 57 | 11,178
Tdark 13 | 6,569
Tchem 12 | 1,885

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
abnormal heart morphology 3 | 162
abnormal neural tube closure 3 | 46
edema 3 | 59
embryonic growth retardation 3 | 106
decreased basophil cell number 2 | 16
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
preweaning lethality, incomple... 2 | 499
abnormal allantois morphology 1 | 8
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal tail morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
bleb 1 | 2
cyanosis 1 | 7
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating lipase l... 1 | 3
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
enlarged lung 1 | 2
hemorrhage 1 | 23
increased bone mineral content 1 | 108
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
long tibia 1 | 25
pale yolk sac 1 | 25
respiratory system phenotype 1 | 2
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19

Disease

Carcinoma 49 | 11,192
ovarian cancer 36 | 8,297
osteosarcoma 35 | 7,766
glioblastoma 31 | 5,635
medulloblastoma, large-cell 31 | 6,086
psoriasis 29 | 6,514
atypical teratoid / rhabdoid tumor 28 | 4,971
ependymoma 21 | 4,559
lung cancer 19 | 4,607
Breast cancer 17 | 3,469
group 3 medulloblastoma 17 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,204
adult high grade glioma 16 | 3,701
pancreatic cancer 16 | 2,322
primitive neuroectodermal tumor 16 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,872
Astrocytoma, Pilocytic 12 | 3,006
Kidney cancer 12 | 2,548
group 4 medulloblastoma 12 | 1,806
pituitary cancer 12 | 1,915
Autosomal recessive predisposition 11 | 1,407
Congenital disorder of glycosylation 11 | 54
invasive ductal carcinoma 11 | 2,867
lung adenocarcinoma 11 | 2,627
lung carcinoma 11 | 2,755
malignant mesothelioma 11 | 3,135
tuberculosis 11 | 1,963
pediatric high grade glioma 10 | 1,035
astrocytic glioma 9 | 2,530
non-small cell lung cancer 9 | 2,799
oligodendroglioma 9 | 2,768
subependymal giant cell astrocytoma 9 | 2,230
Epilepsy 8 | 775
Intellectual disability 8 | 998
Pick disease 8 | 1,856
Seizures 8 | 584
cystic fibrosis 8 | 1,629
non primary Sjogren syndrome sicca 8 | 861
Cognitive delay 7 | 596
Failure to gain weight 7 | 359
Global developmental delay 7 | 596
Mental and motor retardation 7 | 596
Muscle hypotonia 7 | 562
Pediatric failure to thrive 7 | 359
active Crohn's disease 7 | 882
colon cancer 7 | 1,428
interstitial cystitis 7 | 2,237
juvenile dermatomyositis 7 | 1,147
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
Cancer 6 | 2,388
Multiple myeloma 6 | 1,296
Schizophrenia 6 | 1,136
atypical teratoid/rhabdoid tumor 6 | 349
breast carcinoma 6 | 1,589
nasopharyngeal carcinoma 6 | 1,024
Diarrhea 5 | 245
Rheumatoid arthritis 5 | 1,156
active ulcerative colitis 5 | 736
adrenocortical carcinoma 5 | 1,385
aldosterone-producing adenoma 5 | 646
diabetes mellitus 5 | 1,683
gastric carcinoma 5 | 781
posterior fossa group A ependymoma 5 | 456
spina bifida 5 | 1,053
Concave bridge of nose 4 | 191
Depressed nasal bridge 4 | 191
Depressed nasal root/bridge 4 | 191
Exostosis 4 | 15
Hepatomegaly 4 | 280
Isoelectric focusing of serum transferrin consistent with CDG type I 4 | 10
Short stature 4 | 514
Strabismus 4 | 265
acute myeloid leukemia 4 | 760
cutaneous lupus erythematosus 4 | 1,016
ductal carcinoma in situ 4 | 1,686
medulloblastoma 4 | 702
primary Sjogren syndrome 4 | 710
primary pancreatic ductal adenocarcinoma 4 | 1,071
ulcerative colitis 4 | 1,765
Alzheimer's disease 3 | 640
Anemia 3 | 353
Anteverted nostril 3 | 186
Cataract 3 | 290
Dementia 3 | 172
Down syndrome 3 | 480
Dull intelligence 3 | 634
Lissencephaly 3 | 69
Low intelligence 3 | 634
Mental Depression 3 | 325
Mental deficiency 3 | 634
Micromelia 3 | 58
Neurodegenerative disease 3 | 402
Poor school performance 3 | 634
Small head 3 | 366
acute quadriplegic myopathy 3 | 1,133
astrocytoma 3 | 1,113
chronic rhinosinusitis 3 | 505
esophageal adenocarcinoma 3 | 696
hepatocellular carcinoma 3 | 536

Tissue

Endocrine System 79 | 18,159
Digestive Tract 78 | 17,369
Blood and immune system 77 | 16,909
Female tissues 77 | 17,400
Liver and Pancreas 77 | 16,750
Nervous System 77 | 16,725
Skin and soft tissues 76 | 17,230
Male tissues 75 | 17,142
Urinary Tract 75 | 16,678
Respiratory system 74 | 16,393
Cardiovascular System 72 | 15,192

Target Family

Enzyme 73 | 4,145
Non-IDG 9 | 12,091

GO Process

protein glycosylation 82 | 82
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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