Development Level

Tbio 121 | 11,651
Tdark 21 | 6,593
Tchem 15 | 1,388
Tclin 2 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
increased lean body mass 3 | 172
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating total pr... 2 | 49
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
impaired righting response 2 | 26
male infertility 2 | 123
abnormal behavioral response t... 1 | 66
abnormal esophagus morphology 1 | 5
abnormal lens morphology 1 | 81
abnormal limb position 1 | 3
abnormal pancreas morphology 1 | 13
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
enlarged thymus 1 | 5
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality prior to he... 1 | 87
prolonged RR interval 1 | 8
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thin skin 1 | 2
tremors 1 | 39

Disease

ovarian cancer 95 | 8,520
Carcinoma 87 | 11,493
osteosarcoma 69 | 7,950
glioblastoma 55 | 5,792
psoriasis 54 | 6,694
medulloblastoma, large-cell 51 | 6,241
atypical teratoid / rhabdoid tumor 48 | 5,112
lung cancer 48 | 4,740
Breast cancer 38 | 3,578
ependymoma 38 | 4,679
Multiple myeloma 32 | 1,332
adult high grade glioma 30 | 3,801
lung adenocarcinoma 28 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
Astrocytoma, Pilocytic 25 | 3,081
group 3 medulloblastoma 25 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
astrocytic glioma 24 | 2,597
Cancer 23 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
invasive ductal carcinoma 23 | 2,951
non-small cell lung cancer 23 | 2,890
oligodendroglioma 21 | 2,850
acute quadriplegic myopathy 20 | 1,158
astrocytoma 20 | 1,146
diabetes mellitus 20 | 1,728
subependymal giant cell astrocytoma 20 | 2,287
pancreatic cancer 19 | 2,398
Pick disease 18 | 1,894
Rheumatoid arthritis 18 | 1,191
group 4 medulloblastoma 17 | 1,855
lung carcinoma 17 | 2,843
Waldenstrons macroglobulinemia 15 | 765
breast carcinoma 15 | 1,638
juvenile dermatomyositis 15 | 1,187
malignant mesothelioma 15 | 3,232
primitive neuroectodermal tumor 15 | 3,035
dermatomyositis 14 | 966
pituitary cancer 14 | 1,972
tuberculosis 14 | 2,010
Autosomal recessive predisposition 13 | 1,442
active Crohn's disease 13 | 922
colon cancer 13 | 1,478
Prostatic Neoplasms 12 | 495
pediatric high grade glioma 12 | 1,064
Duchenne muscular dystrophy 11 | 601
Intellectual disability 10 | 1,016
acute myeloid leukemia 10 | 783
cystic fibrosis 10 | 1,696
non primary Sjogren syndrome sicca 10 | 891
ulcerative colitis 10 | 1,819
Neurodegenerative disease 9 | 414
Schizophrenia 9 | 1,160
ductal carcinoma in situ 9 | 1,745
interstitial cystitis 9 | 2,312
primary pancreatic ductal adenocarcinoma 9 | 1,109
HIV Infections 8 | 102
medulloblastoma 8 | 720
pancreatic carcinoma 8 | 562
Kidney cancer 7 | 2,613
Parkinson's disease 7 | 392
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
gastric cancer 7 | 459
hereditary spastic paraplegia 7 | 318
Bipolar Disorder 6 | 666
Carcinoma, Squamous Cell 6 | 110
Coronary artery disease 6 | 268
Epilepsy 6 | 792
Retinitis Pigmentosa 6 | 226
Squamous cell carcinoma 6 | 129
Vascular disease 6 | 319
esophageal adenocarcinoma 6 | 737
hepatocellular carcinoma 6 | 547
spina bifida 6 | 1,074
tuberculosis and treatment for 6 months 6 | 409
Asthma 5 | 385
Down syndrome 5 | 499
Hypertension 5 | 396
Hypertensive disease 5 | 292
Male infertility 5 | 206
Myocardial Ischemia 5 | 169
Nystagmus 5 | 317
Prevention of Cardiac Transplant Rejection 5 | 15
Prevention of Kidney Transplant Rejection 5 | 17
Prevention of Liver Transplant Rejection 5 | 15
Renal Cell Carcinoma 5 | 214
Seizures 5 | 596
Stomach Neoplasms 5 | 300
aldosterone-producing adenoma 5 | 665
progressive supranuclear palsy 5 | 676
sonic hedgehog group medulloblastoma 5 | 467
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Becker muscular dystrophy 4 | 191
Depressive disorder 4 | 409
adrenocortical carcinoma 4 | 1,428
cutaneous lupus erythematosus 4 | 1,057
fibroadenoma 4 | 559
nasopharyngeal carcinoma 4 | 1,058

Tissue

Digestive Tract 150 | 17,369
Endocrine System 149 | 18,159
Female tissues 147 | 17,400
Skin and soft tissues 147 | 17,230
Blood and immune system 146 | 16,909
Nervous System 146 | 16,725
Liver and Pancreas 145 | 16,750
Respiratory system 145 | 16,393
Urinary Tract 144 | 16,678
Male tissues 143 | 17,142
Cardiovascular System 140 | 15,192

Target Family

Non-IDG 108 | 12,091
Enzyme 44 | 4,145
Kinase 4 | 634
Transcription Factor 3 | 1,400

GO Process

protein folding 159 | 159
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
DNL-type zinc finger protein DNLZ Tdark Non-IDG -0.90037 8.91 3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase ALG12 Tbio Enzyme -1.10352 13.0 65
Mannosyl-oligosaccharide glucosidase MOGS Tbio Enzyme -2.28289 185.6 149
BAG family molecular chaperone regulator 5 BAG5 Tbio Non-IDG -1.25287 18.4 376
Endoplasmic reticulum resident protein 44 ERP44 Tbio Non-IDG -1.46425 28.0 204
T-complex protein 1 subunit eta CCT7 Tbio Non-IDG -1.42545 26.0 184
Calreticulin CALR Tbio Non-IDG -3.19563 1544.2 778