Development Level

Tbio 187 | 11,445
Tchem 39 | 1,598
Tdark 34 | 6,588
Tclin 11 | 613

IMPC Phenotype

preweaning lethality, complete... 34 | 979
preweaning lethality, incomple... 7 | 499
abnormal behavior 6 | 298
embryonic lethality prior to t... 6 | 278
hypoactivity 6 | 132
decreased body weight 5 | 161
decreased lean body mass 5 | 135
decreased body length 4 | 101
decreased leukocyte cell numbe... 4 | 73
embryonic lethality prior to o... 4 | 239
male infertility 4 | 123
thrombocytopenia 4 | 56
thrombocytosis 4 | 27
corneal opacity 3 | 32
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased circulating glucose ... 3 | 24
increased circulating phosphat... 3 | 26
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular hem... 3 | 36
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal facial morphology 2 | 17
abnormal gait 2 | 69
abnormal head shape 2 | 10
abnormal heart morphology 2 | 162
abnormal limb morphology 2 | 13
abnormal tail morphology 2 | 25
abnormal vocalization 2 | 21
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased red blood cell distr... 2 | 41
female infertility 2 | 60
hyperactivity 2 | 148
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
irregularly shaped pupil 2 | 7
long tibia 2 | 25
microphthalmia 2 | 26
narrow eye opening 2 | 12
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating triglyce... 1 | 79
decreased fluid intake 1 | 3
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
thin ventricular wall 1 | 24

Disease

Carcinoma 178 | 11,493
ovarian cancer 171 | 8,520
osteosarcoma 132 | 7,950
glioblastoma 100 | 5,792
psoriasis 98 | 6,694
lung cancer 88 | 4,740
medulloblastoma, large-cell 84 | 6,241
atypical teratoid / rhabdoid tumor 75 | 5,112
Cancer 72 | 2,499
Breast cancer 58 | 3,578
malignant mesothelioma 56 | 3,232
adult high grade glioma 54 | 3,801
ependymoma 54 | 4,679
group 3 medulloblastoma 53 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,291
oligodendroglioma 47 | 2,850
Kidney cancer 43 | 2,613
Multiple myeloma 43 | 1,332
astrocytic glioma 40 | 2,597
primitive neuroectodermal tumor 40 | 3,035
subependymal giant cell astrocytoma 40 | 2,287
non-small cell lung cancer 39 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
juvenile dermatomyositis 34 | 1,187
lung adenocarcinoma 33 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,962
Astrocytoma, Pilocytic 31 | 3,081
dermatomyositis 31 | 966
diabetes mellitus 30 | 1,728
tuberculosis 30 | 2,010
pancreatic cancer 29 | 2,398
Pick disease 28 | 1,894
invasive ductal carcinoma 28 | 2,951
lung carcinoma 28 | 2,843
group 4 medulloblastoma 27 | 1,855
adrenocortical carcinoma 24 | 1,428
Rheumatoid arthritis 23 | 1,191
Waldenstrons macroglobulinemia 22 | 765
acute quadriplegic myopathy 22 | 1,158
astrocytoma 22 | 1,146
ulcerative colitis 22 | 1,819
acute myeloid leukemia 21 | 783
HIV Infections 20 | 102
breast carcinoma 20 | 1,638
interstitial cystitis 20 | 2,312
cystic fibrosis 19 | 1,696
spina bifida 19 | 1,074
pituitary cancer 18 | 1,972
colon cancer 17 | 1,478
Atopic dermatitis 16 | 952
Intellectual disability 16 | 1,016
Carcinoma, Hepatocellular 15 | 228
Liver carcinoma 15 | 240
cutaneous lupus erythematosus 15 | 1,057
Breast Neoplasms 14 | 445
Liver Cirrhosis, Experimental 14 | 769
Mammary Neoplasms 14 | 425
Melanoma 14 | 711
Prostatic Neoplasms 14 | 495
Schizophrenia 14 | 1,160
active Crohn's disease 14 | 922
ductal carcinoma in situ 14 | 1,745
hepatocellular carcinoma 14 | 547
Bipolar Disorder 13 | 666
Parkinson's disease 13 | 392
primary Sjogren syndrome 13 | 735
Asthma 12 | 385
Vascular disease 12 | 319
Alzheimer's disease 11 | 658
Amyotrophic lateral sclerosis 11 | 451
Bladder Neoplasm 11 | 112
Lung Neoplasms 11 | 232
Stomach Neoplasms 11 | 300
Urinary Bladder Neoplasms 11 | 114
tuberculosis and treatment for 6 months 11 | 409
Autosomal recessive predisposition 10 | 1,442
Crohn's disease 10 | 321
Endometriosis 10 | 540
Neurodegenerative disease 10 | 414
esophageal adenocarcinoma 10 | 737
gastric cancer 10 | 459
nasopharyngeal carcinoma 10 | 1,058
primary pancreatic ductal adenocarcinoma 10 | 1,109
progressive supranuclear palsy 10 | 676
Colonic Neoplasms 9 | 142
Liver cancer 9 | 604
Mental Depression 9 | 333
Pancreatic Neoplasm 9 | 85
Prostate cancer 9 | 175
Short stature 9 | 531
Skin cancer 9 | 469
non primary Sjogren syndrome sicca 9 | 891
Epilepsy 8 | 792
Failure to gain weight 8 | 365
Immune system cancer 8 | 140
Male infertility 8 | 206
Pediatric failure to thrive 8 | 365
Seizures 8 | 596
aldosterone-producing adenoma 8 | 665

Tissue

Endocrine System 253 | 18,159
Female tissues 250 | 17,400
Blood and immune system 249 | 16,909
Digestive Tract 248 | 17,369
Male tissues 248 | 17,142
Nervous System 248 | 16,725
Respiratory system 248 | 16,393
Liver and Pancreas 247 | 16,750
Skin and soft tissues 247 | 17,230
Urinary Tract 247 | 16,678
Cardiovascular System 241 | 15,192

Target Family

Enzyme 147 | 4,145
Non-IDG 91 | 12,091
Transcription Factor 15 | 1,400
Epigenetic 7 | 242
Kinase 7 | 634
Nuclear Receptor 2 | 48
GPCR 1 | 408
Ion Channel 1 | 344

GO Process

protein deubiquitination 271 | 271
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.64460 44.9 288
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4 USP17L4 Tdark Enzyme -0.71476 13.1 3
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 USP17L3 Tdark Enzyme -0.71476 13.1 15
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ubiquitin carboxyl-terminal hydrolase 40 USP40 Tbio Enzyme -0.38917 2.14 68
Ubiquitin carboxyl-terminal hydrolase 29 USP29 Tbio Enzyme -1.22772 15.2 111
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.29685 1936.6 519