Development Level

Tbio 65 | 11,445
Tchem 22 | 1,598
Tdark 3 | 6,588
Tclin 1 | 613

IMPC Phenotype

abnormal bone structure 7 | 187
increased lean body mass 5 | 172
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
decreased bone mineral content 3 | 151
abnormal sleep behavior 2 | 70
brachydactyly 2 | 19
decreased body length 2 | 101
decreased circulating magnesiu... 2 | 13
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
edema 2 | 59
enlarged heart 2 | 210
increased bone mineral content 2 | 108
increased fasted circulating g... 2 | 76
male infertility 2 | 123
prolonged ST segment 2 | 36
syndactyly 2 | 23
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal locomotor behavior 1 | 24
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased cornea thickness 1 | 2
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
small kidney 1 | 16
small superior vagus ganglion 1 | 74
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 66 | 11,493
ovarian cancer 54 | 8,520
osteosarcoma 45 | 7,950
glioblastoma 41 | 5,792
medulloblastoma, large-cell 40 | 6,241
psoriasis 39 | 6,694
atypical teratoid / rhabdoid tumor 35 | 5,112
adult high grade glioma 31 | 3,801
ependymoma 30 | 4,679
malignant mesothelioma 29 | 3,232
lung cancer 28 | 4,740
Kidney cancer 24 | 2,613
group 3 medulloblastoma 23 | 4,104
Breast cancer 20 | 3,578
oligodendroglioma 19 | 2,850
subependymal giant cell astrocytoma 19 | 2,287
Cancer 18 | 2,499
astrocytic glioma 18 | 2,597
group 4 medulloblastoma 18 | 1,855
Astrocytoma, Pilocytic 17 | 3,081
Pick disease 17 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
invasive ductal carcinoma 16 | 2,951
non-small cell lung cancer 16 | 2,890
colon cancer 15 | 1,478
lung carcinoma 15 | 2,843
spina bifida 15 | 1,074
interstitial cystitis 14 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
primitive neuroectodermal tumor 14 | 3,035
lung adenocarcinoma 13 | 2,716
pituitary cancer 13 | 1,972
tuberculosis 13 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
ulcerative colitis 12 | 1,819
ductal carcinoma in situ 11 | 1,745
pancreatic cancer 11 | 2,398
Melanoma 10 | 711
Skin cancer 10 | 469
breast carcinoma 10 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Multiple myeloma 9 | 1,332
dermatomyositis 9 | 966
Rheumatoid arthritis 8 | 1,191
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 665
diabetes mellitus 8 | 1,728
juvenile dermatomyositis 8 | 1,187
Autosomal recessive predisposition 7 | 1,442
Liver Cirrhosis, Experimental 7 | 769
active ulcerative colitis 7 | 764
acute quadriplegic myopathy 7 | 1,158
cystic fibrosis 7 | 1,696
primary Sjogren syndrome 7 | 735
Chronic Lymphocytic Leukemia 6 | 262
Endometrial cancer 6 | 311
Epilepsy 6 | 792
Schizophrenia 6 | 1,160
cutaneous lupus erythematosus 6 | 1,057
gastric carcinoma 6 | 807
pediatric high grade glioma 6 | 1,064
primary pancreatic ductal adenocarcinoma 6 | 1,109
urothelial carcinoma 6 | 318
Alzheimer's disease 5 | 658
Crohn's disease 5 | 321
Hypertension 5 | 396
Kidney disease 5 | 430
Liver cancer 5 | 604
Neuropathy 5 | 261
active Crohn's disease 5 | 922
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
Acquired metabolic disease 4 | 336
Acquired scoliosis 4 | 281
Asthma 4 | 385
Atopic dermatitis 4 | 952
Breast Neoplasms 4 | 445
Centronuclear myopathy 4 | 27
Cognitive delay 4 | 608
Curvature of spine 4 | 282
Disease Progression 4 | 136
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Mammary Neoplasms 4 | 425
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
Obesity 4 | 678
Prostatic Neoplasms 4 | 495
Seizures 4 | 596
Vascular disease 4 | 319
acute myeloid leukemia 4 | 783
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 459
hereditary spastic paraplegia 4 | 318
nasopharyngeal carcinoma 4 | 1,058
non primary Sjogren syndrome sicca 4 | 891
Cognitive disorder 3 | 50
Duchenne muscular dystrophy 3 | 601
Immune system cancer 3 | 140

Tissue

Endocrine System 90 | 18,159
Female tissues 89 | 17,400
Blood and immune system 88 | 16,909
Male tissues 88 | 17,142
Skin and soft tissues 88 | 17,230
Digestive Tract 87 | 17,369
Liver and Pancreas 87 | 16,750
Nervous System 87 | 16,725
Urinary Tract 87 | 16,678
Cardiovascular System 86 | 15,192
Respiratory system 86 | 16,393

Target Family

Enzyme 83 | 4,145
Non-IDG 8 | 12,091

GO Process

protein dephosphorylation 91 | 91
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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