Development Level

Tbio 51 | 11,445
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating alkaline... 4 | 46
abnormal behavior 3 | 298
decreased body length 3 | 101
decreased body weight 3 | 161
hypoactivity 3 | 132
abnormal sleep behavior 2 | 70
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
female infertility 2 | 60
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal hindlimb morphology 1 | 2
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb position 1 | 3
abnormal locomotor behavior 1 | 24
abnormal retinal blood vessel ... 1 | 26
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
cataract 1 | 92
convulsive seizures 1 | 13
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased body temperature 1 | 9
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
prolonged RR interval 1 | 8
shortened ST segment 1 | 10
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 35 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 26 | 7,950
psoriasis 23 | 6,694
medulloblastoma, large-cell 22 | 6,241
glioblastoma 21 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 13 | 4,679
lung cancer 12 | 4,740
primitive neuroectodermal tumor 12 | 3,035
Cancer 11 | 2,499
Multiple myeloma 11 | 1,332
adult high grade glioma 11 | 3,801
astrocytic glioma 11 | 2,597
group 3 medulloblastoma 11 | 4,104
Breast cancer 10 | 3,578
oligodendroglioma 10 | 2,850
subependymal giant cell astrocytoma 10 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
malignant mesothelioma 9 | 3,232
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
pancreatic cancer 8 | 2,398
spina bifida 8 | 1,074
Autosomal recessive predisposition 7 | 1,442
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
pituitary cancer 7 | 1,972
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung carcinoma 6 | 2,843
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Rheumatoid arthritis 5 | 1,191
invasive ductal carcinoma 5 | 2,951
Alzheimer's disease 4 | 658
Dry skin 4 | 75
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Poor school performance 4 | 645
Strabismus 4 | 270
Xerosis 4 | 75
acute quadriplegic myopathy 4 | 1,158
cystic fibrosis 4 | 1,696
medulloblastoma 4 | 720
primary Sjogren syndrome 4 | 735
Anemia 3 | 365
Atopic dermatitis 3 | 952
Autistic Disorder 3 | 364
Autosomal recessive limb-girdle muscular dystrophy type 2H 3 | 7
Breast Neoplasms 3 | 445
Dysarthria 3 | 192
Epilepsy 3 | 792
Hepatomegaly 3 | 285
Male infertility 3 | 206
Mammary Neoplasms 3 | 425
Melanoma 3 | 711
Neurodegenerative disease 3 | 414
Seizures 3 | 596
Thrombocytopenia 3 | 197
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
hepatocellular carcinoma 3 | 547
interstitial cystitis 3 | 2,312
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
Acquired scoliosis 2 | 281
Adenoid Cystic Carcinoma 2 | 99
Carcinoma, Adenoid Cystic 2 | 99
Chronic obstructive pulmonary disease 2 | 184
Cockayne syndrome 2 | 60
Colonic Neoplasms 2 | 142
Concave bridge of nose 2 | 195
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Disease Progression 2 | 136
Down syndrome 2 | 499
Failure to gain weight 2 | 365
Hemoglobin low 2 | 124
Hypertension 2 | 396
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Pancreatic Neoplasm 2 | 85
Pediatric failure to thrive 2 | 365
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
posterior fossa group B ependymoma 2 | 416

Tissue

Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Respiratory system 55 | 16,393
Blood and immune system 54 | 16,909
Liver and Pancreas 54 | 16,750
Male tissues 54 | 17,142
Nervous System 54 | 16,725
Skin and soft tissues 54 | 17,230
Urinary Tract 54 | 16,678
Cardiovascular System 53 | 15,192
Digestive Tract 53 | 17,369

Target Family

Enzyme 31 | 4,145
Non-IDG 21 | 12,091
Epigenetic 3 | 242

GO Process

protein autoubiquitination 55 | 55
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.57250 40.4 202
RING finger protein 141 RNF141 Tbio Non-IDG -0.52988 3.40 159
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.53597 32.3 117
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Bifunctional apoptosis regulator BFAR Tbio Non-IDG -0.66842 3.95 163
E3 ubiquitin-protein ligase listerin LTN1 Tbio Enzyme -1.46975 30.1 88
E3 ubiquitin-protein ligase RNF187 RNF187 Tbio Enzyme -0.38021 3.46 42
E3 ubiquitin-protein ligase RNF133 RNF133 Tdark Enzyme 0.00000 1.00 151