Development Level

Tchem 113 | 1,890
Tclin 27 | 602
Tbio 24 | 10,625
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 12 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
decreased bone mineral content 5 | 157
abnormal bone structure 4 | 131
embryonic lethality prior to t... 4 | 187
decreased lean body mass 3 | 195
embryonic lethality prior to o... 3 | 148
increased blood urea nitrogen ... 3 | 44
abnormal embryo size 2 | 112
decreased body length 2 | 108
decreased body weight 2 | 174
decreased total body fat amoun... 2 | 186
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal coat/ hair morphology 1 | 18
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
absent vibrissae 1 | 14
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased eosinophil cell numb... 1 | 41
decreased granulocyte number 1 | 8
decreased leukocyte cell numbe... 1 | 54
decreased memory-marker CD4-po... 1 | 4
decreased prepulse inhibition 1 | 52
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
improved glucose tolerance 1 | 56
increased Ly6C low monocyte nu... 1 | 8
increased NK cell number 1 | 19
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased respiratory quotient 1 | 12
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
small testis 1 | 37
tremors 1 | 34

Disease

osteosarcoma 105 | 7,933
ovarian cancer 95 | 8,484
medulloblastoma, large-cell 82 | 6,234
Cancer 74 | 2,346
glioblastoma 69 | 5,572
psoriasis 67 | 6,685
Carcinoma 63 | 2,147
lung cancer 59 | 4,466
atypical teratoid / rhabdoid tumor 57 | 4,369
non-small cell lung cancer 55 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,289
invasive ductal carcinoma 46 | 2,950
Breast cancer 44 | 3,094
oligodendroglioma 43 | 2,849
malignant mesothelioma 42 | 3,162
pilocytic astrocytoma 41 | 3,086
lung carcinoma 40 | 2,844
primitive neuroectodermal tumor 40 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
Renal Cell Carcinoma 36 | 199
ependymoma 36 | 2,514
pediatric high grade glioma 36 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
lung adenocarcinoma 32 | 2,713
pancreatic cancer 32 | 2,300
Pick disease 31 | 1,893
astrocytic glioma 31 | 2,241
subependymal giant cell astrocytoma 30 | 2,287
group 3 medulloblastoma 29 | 2,254
interstitial cystitis 29 | 2,299
ulcerative colitis 28 | 2,087
Gastrointestinal stromal tumor 26 | 61
cystic fibrosis 26 | 1,665
Blastic phase chronic myeloid leukemia 25 | 58
Chronic Myelocytic Leukemia Accelerated Phase 25 | 59
adult high grade glioma 25 | 2,148
astrocytoma 25 | 1,493
adrenocortical carcinoma 24 | 1,427
medulloblastoma 24 | 1,524
Pancreatic Neuroendocrine Tumor 23 | 45
breast carcinoma 23 | 1,614
diabetes mellitus 22 | 1,663
ductal carcinoma in situ 21 | 1,745
pituitary cancer 21 | 1,972
group 4 medulloblastoma 20 | 1,875
tuberculosis 20 | 1,557
Hamman-Rich syndrome 19 | 35
Philadelphia chromosome-positive acute lymphoblastic leukemia 19 | 47
spina bifida 19 | 1,064
Alzheimer's disease 18 | 644
Chronic phase chronic myeloid leukemia 18 | 45
Mammary Neoplasms 18 | 410
Parkinson's disease 18 | 364
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 18 | 45
posterior fossa group B ependymoma 17 | 1,530
esophageal adenocarcinoma 16 | 737
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
primary pancreatic ductal adenocarcinoma 16 | 1,271
sonic hedgehog group medulloblastoma 16 | 1,482
Rheumatoid Arthritis 15 | 1,160
colon cancer 15 | 1,475
cutaneous lupus erythematosus 15 | 1,056
posterior fossa group A ependymoma 15 | 1,511
Multiple myeloma 14 | 1,327
Schizophrenia 14 | 501
juvenile dermatomyositis 14 | 1,189
acute quadriplegic myopathy 13 | 1,157
progressive supranuclear palsy 13 | 674
Intellectual disability 12 | 573
Prostatic Neoplasms 12 | 471
atypical teratoid/rhabdoid tumor 12 | 1,095
dermatomyositis 12 | 933
Obesity 11 | 616
Peripheral Neuropathy 11 | 303
Amyotrophic Lateral Sclerosis 10 | 431
Carcinoma of thyroid 10 | 17
Papillary thyroid carcinoma 10 | 37
Adenocarcinoma 9 | 115
Colorectal Neoplasms 9 | 217
Endometriosis 9 | 535
Epilepsy 9 | 346
Hypertension 9 | 287
Liver cell carcinoma 9 | 15
Lung Neoplasms 9 | 171
Neurodegenerative disease 9 | 383
Sarcoma of soft tissue 9 | 11
Vascular disease 9 | 281
Waldenstrons macroglobulinemia 9 | 765
gastric carcinoma 9 | 832
non-small cell lung carcinoma 9 | 413
Kidney disease 8 | 396
Status Epilepticus 8 | 85
aldosterone-producing adenoma 8 | 664
nasopharyngeal carcinoma 8 | 1,056
non primary Sjogren syndrome sicca 8 | 840
primary Sjogren syndrome 8 | 789
tuberculosis and treatment for 6 months 8 | 686
Atopic dermatitis 7 | 944
Melanoma 7 | 261
pancreatic carcinoma 7 | 567

Tissue

Liver and Pancreas 166 | 18,136
Blood and immune system 165 | 17,995
Digestive Tract 165 | 18,473
Endocrine System 165 | 18,512
Female tissues 165 | 18,647
Male tissues 165 | 17,969
Nervous System 165 | 18,561
Urinary Tract 165 | 18,444
Cardiovascular System 164 | 17,958
Skin and soft tissues 164 | 18,115
Respiratory system 163 | 17,484

Target Family

Kinase 156 | 634
Non-IDG 6 | 11,971
Epigenetic 2 | 242
Ion Channel 1 | 341
Transporter 1 | 473

GO Process

protein autophosphorylation 166 | 166
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Epithelial discoidin domain-containing receptor 1 DDR1 Tchem Kinase -2.21530 0.00000 460
Homeodomain-interacting protein kinase 4 HIPK4 Tchem Kinase -0.20862 2.17 190
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Breakpoint cluster region protein BCR Tclin Non-IDG -2.96152 896.0 391
Serine/threonine-protein kinase pim-1 PIM1 Tchem Kinase -2.81405 700.5 520
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.07424 1194.2 1600