Development Level

Tchem 122 | 1,598
Tclin 28 | 613
Tbio 15 | 11,445
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 12 | 125
Kinase: IDG Consortium (Comple... 10 | 37

IMPC Phenotype

abnormal bone structure 8 | 187
preweaning lethality, complete... 8 | 979
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to o... 5 | 239
abnormal behavior 4 | 298
decreased bone mineral content 4 | 151
abnormal embryo size 3 | 220
increased blood urea nitrogen ... 3 | 48
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
abnormal behavioral response t... 2 | 66
abnormal eye anterior chamber ... 2 | 9
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
abnormal spinal cord morpholog... 2 | 9
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased body length 2 | 32
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
abnormal clavicle morphology 1 | 6
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retinal outer nuclear... 1 | 3
abnormal rib morphology 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
absent vibrissae 1 | 12
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased granulocyte number 1 | 6
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased urine magnesium leve... 1 | 2
increased vertical activity 1 | 24
male infertility 1 | 123
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
sclerocornea 1 | 2
short tibia 1 | 97
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 149 | 11,493
osteosarcoma 106 | 7,950
ovarian cancer 100 | 8,520
medulloblastoma, large-cell 84 | 6,241
Cancer 79 | 2,499
glioblastoma 75 | 5,792
lung cancer 70 | 4,740
atypical teratoid / rhabdoid tumor 68 | 5,112
psoriasis 68 | 6,694
Kidney cancer 67 | 2,613
ependymoma 60 | 4,679
non-small cell lung cancer 56 | 2,890
Breast cancer 55 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,291
group 3 medulloblastoma 52 | 4,104
adult high grade glioma 50 | 3,801
invasive ductal carcinoma 46 | 2,951
malignant mesothelioma 45 | 3,232
oligodendroglioma 43 | 2,850
Astrocytoma, Pilocytic 42 | 3,081
primitive neuroectodermal tumor 41 | 3,035
astrocytic glioma 40 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
lung carcinoma 39 | 2,843
Renal Cell Carcinoma 38 | 214
pancreatic cancer 34 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
lung adenocarcinoma 33 | 2,716
subependymal giant cell astrocytoma 31 | 2,287
Pick disease 30 | 1,894
interstitial cystitis 30 | 2,312
ulcerative colitis 28 | 1,819
breast carcinoma 27 | 1,638
cystic fibrosis 27 | 1,696
Gastrointestinal stromal tumor 26 | 62
Schizophrenia 26 | 1,160
adrenocortical carcinoma 26 | 1,428
Blastic phase chronic myeloid leukemia 25 | 58
Chronic Myelocytic Leukemia Accelerated Phase 25 | 59
diabetes mellitus 24 | 1,728
Pancreatic Neuroendocrine Tumor 23 | 45
group 4 medulloblastoma 23 | 1,855
tuberculosis 23 | 2,010
ductal carcinoma in situ 22 | 1,745
Autosomal recessive predisposition 21 | 1,442
Intellectual disability 20 | 1,016
pituitary cancer 20 | 1,972
Breast Neoplasms 19 | 445
Hamman-Rich syndrome 19 | 34
Mammary Neoplasms 19 | 425
Philadelphia chromosome-positive acute lymphoblastic leukemia 19 | 47
spina bifida 19 | 1,074
Alzheimer's disease 18 | 658
Chronic phase chronic myeloid leukemia 18 | 45
Parkinson's disease 18 | 392
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 18 | 45
astrocytoma 18 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Rheumatoid arthritis 17 | 1,191
esophageal adenocarcinoma 17 | 737
colon cancer 16 | 1,478
Epilepsy 15 | 792
Skin cancer 15 | 469
cutaneous lupus erythematosus 15 | 1,057
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Multiple myeloma 14 | 1,332
Poor school performance 14 | 645
Prostatic Neoplasms 14 | 495
juvenile dermatomyositis 14 | 1,187
primary pancreatic ductal adenocarcinoma 14 | 1,109
Cognitive delay 13 | 608
Depressive disorder 13 | 409
Global developmental delay 13 | 608
Melanoma 13 | 711
Mental and motor retardation 13 | 608
Obesity 13 | 678
acute quadriplegic myopathy 13 | 1,158
pediatric high grade glioma 13 | 1,064
Bipolar Disorder 12 | 666
Liver cancer 12 | 604
dermatomyositis 12 | 966
progressive supranuclear palsy 12 | 676
Hypertension 11 | 396
Liver Cirrhosis, Experimental 11 | 769
Stomach Neoplasms 11 | 300
Amyotrophic lateral sclerosis 10 | 451
Carcinoma of thyroid 10 | 17
Colorectal Neoplasms 10 | 243
Endometriosis 10 | 540
Kidney disease 10 | 430
Lung Neoplasms 10 | 232
Major Depressive Disorder 10 | 301
Neurodegenerative disease 10 | 414
Papillary thyroid carcinoma 10 | 43
Short stature 10 | 531
Small head 10 | 374
gastric carcinoma 10 | 807

Tissue

Endocrine System 168 | 18,159
Digestive Tract 166 | 17,369
Skin and soft tissues 166 | 17,230
Blood and immune system 164 | 16,909
Female tissues 164 | 17,400
Liver and Pancreas 163 | 16,750
Male tissues 163 | 17,142
Nervous System 161 | 16,725
Urinary Tract 161 | 16,678
Respiratory system 159 | 16,393
Cardiovascular System 154 | 15,192

Target Family

Kinase 159 | 634
Non-IDG 5 | 12,091
Epigenetic 2 | 242
Ion Channel 1 | 344
Transporter 1 | 473

GO Process

protein autophosphorylation 168 | 168
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Serine/threonine-protein kinase VRK2 VRK2 Tbio Kinase -1.28897 20.5 123
PAS domain-containing serine/threonine-protein kinase PASK Tbio Kinase -1.01354 12.3 95
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317