Development Level

Tbio 34 | 11,445
Tdark 6 | 6,588
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal seminal vesicle morph... 2 | 114
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal neural tube closure 1 | 46
bleb 1 | 2
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small adrenal glands 1 | 16
small spleen 1 | 19

Disease

ovarian cancer 34 | 8,520
Carcinoma 24 | 11,493
glioblastoma 23 | 5,792
osteosarcoma 23 | 7,950
medulloblastoma, large-cell 18 | 6,241
ependymoma 16 | 4,679
atypical teratoid / rhabdoid tumor 15 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
psoriasis 15 | 6,694
Astrocytoma, Pilocytic 13 | 3,081
lung cancer 13 | 4,740
Multiple myeloma 12 | 1,332
lung adenocarcinoma 12 | 2,716
adult high grade glioma 11 | 3,801
pancreatic cancer 11 | 2,398
Breast cancer 10 | 3,578
group 3 medulloblastoma 10 | 4,104
interstitial cystitis 10 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Autosomal recessive predisposition 9 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
non-small cell lung cancer 9 | 2,890
Congenital disorder of glycosylation 8 | 54
group 4 medulloblastoma 8 | 1,855
astrocytoma 7 | 1,146
invasive ductal carcinoma 7 | 2,951
non primary Sjogren syndrome sicca 7 | 891
ulcerative colitis 7 | 1,819
Epilepsy 6 | 792
Kidney cancer 6 | 2,613
Pick disease 6 | 1,894
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
pancreatic carcinoma 6 | 562
subependymal giant cell astrocytoma 6 | 2,287
Failure to gain weight 5 | 365
Pediatric failure to thrive 5 | 365
Schizophrenia 5 | 1,160
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
lung carcinoma 5 | 2,843
tuberculosis 5 | 2,010
Cancer 4 | 2,499
Cognitive delay 4 | 608
Creatine phosphokinase serum increased 4 | 110
Elevated creatine kinase 4 | 110
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Seizures 4 | 596
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
pediatric high grade glioma 4 | 1,064
primitive neuroectodermal tumor 4 | 3,035
Amyotrophic lateral sclerosis 3 | 451
Congenital muscular dystrophy 3 | 29
Isoelectric focusing of serum transferrin consistent with CDG type I 3 | 10
Liver Dysfunction 3 | 99
Lower limb hyperreflexia 3 | 10
Muscular dystrophy 3 | 75
Optic Atrophy 3 | 242
Small head 3 | 374
Strabismus 3 | 270
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
periodontitis 3 | 293
pituitary cancer 3 | 1,972
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Alzheimer's disease 2 | 658
Attention deficit hyperactivity disorder 2 | 278
Elevated hepatic transaminases 2 | 81
Familial encephalopathy with neuroserpin inclusion bodies 2 | 10
Hepatic enzyme increased 2 | 81
Infantile onset 2 | 238
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Multiple Sclerosis 2 | 540
Physical aggression 2 | 76
Progressive disorder 2 | 142
Prostatic Neoplasms 2 | 495
Psychotic Disorders 2 | 151
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
medulloblastoma 2 | 720
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 45 | 18,159
Skin and soft tissues 45 | 17,230
Digestive Tract 44 | 17,369
Female tissues 44 | 17,400
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Nervous System 44 | 16,725
Urinary Tract 44 | 16,678
Blood and immune system 43 | 16,909
Cardiovascular System 43 | 15,192
Respiratory system 43 | 16,393

Target Family

Enzyme 33 | 4,145
Non-IDG 12 | 12,091

GO Process

protein N-linked glycosylation... 45 | 45
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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