Development Level

Tbio 34 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
abnormal bone structure 2 | 187
decreased circulating triglyce... 2 | 79
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cystolithiasis 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small liver 1 | 8
thick skin 1 | 4
tremors 1 | 39

Disease

ovarian cancer 21 | 8,520
Carcinoma 19 | 11,493
psoriasis 18 | 6,694
lung cancer 13 | 4,740
osteosarcoma 13 | 7,950
glioblastoma 12 | 5,792
ependymoma 11 | 4,679
atypical teratoid / rhabdoid tumor 10 | 5,112
Cancer 9 | 2,499
adult high grade glioma 9 | 3,801
astrocytic glioma 9 | 2,597
medulloblastoma, large-cell 9 | 6,241
Astrocytoma, Pilocytic 8 | 3,081
primitive neuroectodermal tumor 8 | 3,035
oligodendroglioma 7 | 2,850
Breast cancer 6 | 3,578
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pituitary cancer 5 | 1,972
Liddle syndrome 4 | 14
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
Autistic Disorder 3 | 364
Autosomal recessive predisposition 3 | 1,442
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
Acquired scoliosis 2 | 281
Almond-shaped eyes 2 | 23
Alzheimer's disease 2 | 658
Angelman syndrome 2 | 34
Attention deficit hyperactivity disorder 2 | 278
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Cognitive delay 2 | 608
Curvature of spine 2 | 282
Dull intelligence 2 | 645
Fanconi anemia 2 | 56
Global developmental delay 2 | 608
Low intelligence 2 | 645
Lung Neoplasms 2 | 232
Lymphoma 2 | 81
Mammary Neoplasms 2 | 425
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Poor school performance 2 | 645
Short stature 2 | 531
Stomach Neoplasms 2 | 300
acute quadriplegic myopathy 2 | 1,158
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
gastric cancer 2 | 459
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
ulcerative colitis 2 | 1,819
Adenocarcinoma Of Esophagus 1 | 14
Aggressive systemic mastocytosis 1 | 20
Ataxia telangiectasia 1 | 34
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 1 | 13
Brain Neoplasms 1 | 33
Bronchioloalveolar Adenocarcinoma 1 | 14
Carcinogenesis 1 | 8
Chromosome Breakage 1 | 36
Decreased pain sensation 1 | 17
Dent disease 1 | 18
Familial Mediterranean fever 1 | 13
Gait, Unsteady 1 | 29
Hypoplasia of thumb 1 | 26
Increased chromosomal breakage 1 | 27
LI-FRAUMENI SYNDROME 1 1 | 2
Leprosy 1 | 73
Measles 1 | 22
Memory Disorders 1 | 40
Neoplasms 1 | 63
Photosensitivity of skin 1 | 51
Radial aplasia/hypoplasia 1 | 29
Rheumatic fever 1 | 19
Rubella 1 | 15
Urogenital Neoplasms 1 | 3

Tissue

Blood and immune system 35 | 16,909
Digestive Tract 35 | 17,369
Endocrine System 35 | 18,159
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678
Cardiovascular System 33 | 15,192

Target Family

Non-IDG 20 | 12,091
Enzyme 15 | 4,145
Transcription Factor 1 | 1,400

GO Process

protein K63-linked ubiquitinat... 36 | 36
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Bifunctional apoptosis regulator BFAR Tbio Non-IDG -0.66842 3.95 163
Ubiquitin-conjugating enzyme E2 G1 UBE2G1 Tbio Non-IDG -0.84360 6.17 155
Ubiquitin-conjugating enzyme E2 S UBE2S Tbio Non-IDG -2.36597 158.3 384
Putative ubiquitin-conjugating enzyme E2 N-like UBE2NL Tdark Non-IDG -0.47366 3.56 0
E3 ubiquitin-protein ligase ARIH2 ARIH2 Tbio Enzyme -1.44450 28.4 251
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
E3 ubiquitin-protein ligase RNF152 RNF152 Tbio Enzyme -0.34321 1.96 2