Development Level

Tbio 47 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
decreased circulating triglyce... 3 | 79
enlarged heart 3 | 210
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
male infertility 2 | 123
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal esophagus morphology 1 | 5
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cystolithiasis 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small liver 1 | 8
thick skin 1 | 4
tremors 1 | 39

Disease

ovarian cancer 37 | 8,520
Carcinoma 25 | 11,493
glioblastoma 23 | 5,792
medulloblastoma, large-cell 20 | 6,241
psoriasis 20 | 6,694
atypical teratoid / rhabdoid tumor 17 | 5,112
osteosarcoma 17 | 7,950
ependymoma 16 | 4,679
lung cancer 16 | 4,740
adult high grade glioma 15 | 3,801
Breast cancer 14 | 3,578
astrocytic glioma 13 | 2,597
Multiple myeloma 12 | 1,332
oligodendroglioma 12 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
spina bifida 11 | 1,074
Rheumatoid arthritis 9 | 1,191
primitive neuroectodermal tumor 9 | 3,035
group 3 medulloblastoma 8 | 4,104
lung adenocarcinoma 8 | 2,716
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
Astrocytoma, Pilocytic 7 | 3,081
acute quadriplegic myopathy 7 | 1,158
esophageal adenocarcinoma 7 | 737
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Cancer 6 | 2,499
Pick disease 6 | 1,894
breast carcinoma 6 | 1,638
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
medulloblastoma 6 | 720
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Alzheimer's disease 5 | 658
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
Parkinson's disease 5 | 392
acute myeloid leukemia 5 | 783
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
non primary Sjogren syndrome sicca 5 | 891
Autistic Disorder 4 | 364
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple Sclerosis 4 | 540
Poor school performance 4 | 645
adrenocortical carcinoma 4 | 1,428
cystic fibrosis 4 | 1,696
lung carcinoma 4 | 2,843
ulcerative colitis 4 | 1,819
Autosomal recessive limb-girdle muscular dystrophy type 2H 3 | 7
Endometriosis 3 | 540
Gaucher disease type 1 3 | 180
Kidney disease 3 | 430
Liddle syndrome 3 | 14
Nystagmus 3 | 317
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
cutaneous lupus erythematosus 3 | 1,057
ductal carcinoma in situ 3 | 1,745
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
Acquired scoliosis 2 | 281
Amyotrophic lateral sclerosis 2 | 451
Atopic dermatitis 2 | 952
Cerebral atrophy 2 | 178
Colonic Neoplasms 2 | 142
Crohn's disease 2 | 321
Curvature of spine 2 | 282
Dementia 2 | 175
Diabetes Mellitus, Type 2 2 | 142
Down syndrome 2 | 499
Epilepsy 2 | 792
Familial encephalopathy with neuroserpin inclusion bodies 2 | 10
Hyperreflexia 2 | 209
Hypertension 2 | 396
Infertility 2 | 188
Liver cancer 2 | 604
Male infertility 2 | 206
Neurodegenerative disease 2 | 414
Polycystic ovary syndrome 2 | 360
Retinal pigment epithelial abnormality 2 | 111
Seizures 2 | 596
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
diabetes mellitus 2 | 1,728
gastric carcinoma 2 | 807
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
tuberculosis 2 | 2,010
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 47 | 16,909
Cardiovascular System 47 | 15,192
Digestive Tract 47 | 17,369
Endocrine System 47 | 18,159
Female tissues 47 | 17,400
Liver and Pancreas 47 | 16,750
Male tissues 47 | 17,142
Nervous System 47 | 16,725
Respiratory system 47 | 16,393
Skin and soft tissues 47 | 17,230
Urinary Tract 47 | 16,678

Target Family

Enzyme 26 | 4,145
Non-IDG 21 | 12,091

GO Process

protein K48-linked ubiquitinat... 47 | 47
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Ubiquitin-conjugating enzyme E2 A UBE2A Tbio Non-IDG -1.53597 32.3 117
Bifunctional apoptosis regulator BFAR Tbio Non-IDG -0.66842 3.95 163
E3 ubiquitin-protein ligase TTC3 TTC3 Tbio Enzyme -1.32729 21.4 58
E3 ubiquitin-protein ligase RNF187 RNF187 Tbio Enzyme -0.38021 3.46 42
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
Ubiquitin-conjugating enzyme E2 H UBE2H Tbio Non-IDG -1.28252 18.7 166
Ubiquitin-conjugating enzyme E2 G1 UBE2G1 Tbio Non-IDG -0.84360 6.17 155
Ubiquitin-conjugating enzyme E2 R2 UBE2R2 Tbio Non-IDG 0.11 0.74 128