Development Level

Tbio 19 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased body weight 2 | 161
abnormal heart position or ori... 1 | 1
abnormal lung morphology 1 | 26
abnormal vocalization 1 | 21
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased circulating choleste... 1 | 93
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
long tibia 1 | 25
thrombocytosis 1 | 27

Disease

Carcinoma 18 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 12 | 8,520
medulloblastoma, large-cell 11 | 6,241
atypical teratoid / rhabdoid tumor 7 | 5,112
psoriasis 6 | 6,694
Kidney cancer 5 | 2,613
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
group 4 medulloblastoma 5 | 1,855
lung cancer 5 | 4,740
malignant mesothelioma 5 | 3,232
subependymal giant cell astrocytoma 5 | 2,287
Pick disease 4 | 1,894
diabetes mellitus 4 | 1,728
lung carcinoma 4 | 2,843
spina bifida 4 | 1,074
Breast cancer 3 | 3,578
active ulcerative colitis 3 | 764
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Cancer 2 | 2,499
Rheumatoid arthritis 2 | 1,191
dermatomyositis 2 | 966
esophageal adenocarcinoma 2 | 737
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Abnormality of the lymphatic system 1 | 14
Acne 1 | 52
Ataxia, Appendicular 1 | 25
Ataxia, Truncal 1 | 21
Autosomal dominant cerebellar ataxia 1 | 33
Basal cell carcinoma 1 | 54
Blind loop syndrome 1 | 2
Bone neoplasms 1 | 8
Carcinoma, Basal Cell 1 | 28
Carcinoma, Renal Cell 1 | 124
Celiac disease 1 | 116
Cell Transformation, Neoplastic 1 | 97
DOID:9917 1 | 31
Deglutition Disorders 1 | 132
Dry skin 1 | 75
Dysmetric saccades 1 | 9
Freckles 1 | 33
Friedreich ataxia 1 | 24
Generalized hirsutism 1 | 36
Hair shaft abnormalities 1 | 30
Head and Neck Neoplasms 1 | 26
Hereditary Melanoma 1 | 12
Hypokalemia 1 | 52
Juvenile rheumatoid arthritis 1 | 111
Kidney Neoplasm 1 | 29
Kidney Neoplasms 1 | 37
Lipoma 1 | 32
Lymphatic Diseases 1 | 14
Lymphoid leukemia 1 | 160
Lymphoma, T-Cell, Cutaneous 1 | 22
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
Meningioma 1 | 41
Menorrhagia 1 | 25
Multiple system atrophy 1 | 29
Muscle Cramp 1 | 55
Muscle Rigidity 1 | 49
Neoplastic Cell Transformation 1 | 89
Nevus 1 | 19
Obesity, Abdominal 1 | 24
Ocular cancer 1 | 7
Ovarian Neoplasms 1 | 102
PARKINSON DISEASE, LATE-ONSET 1 | 20
Panic disorder 1 | 61
Paraganglioma 1 | 15
Paralytic ileus 1 | 5
Postural instability 1 | 19
Progressive cerebellar ataxia 1 | 13
Renal Cell Carcinoma 1 | 214
Restless legs syndrome 1 | 27
Round face 1 | 45
Round, full face 1 | 45
Spinocerebellar ataxia type 1 1 | 16
Spinocerebellar ataxia type 2 1 | 23
Stomach cancer 1 | 30
Testicular Neoplasms 1 | 6
Thymoma 1 | 16
Uveal melanoma 1 | 20
Xerosis 1 | 75
familial melanoma 1 | 10
hair abnormalities (non-specific) 1 | 30
non-syndromic X-linked intellectual disability 1 | 20
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 20 | 16,909
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Cardiovascular System 19 | 15,192

Target Family

Enzyme 13 | 4,145
Non-IDG 8 | 12,091

GO Process

protein K48-linked deubiquitin... 21 | 21
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
OTU domain-containing protein 4 OTUD4 Tbio Non-IDG -0.45864 3.06 138
Ubiquitin thioesterase OTU1 YOD1 Tbio Enzyme -1.63573 39.8 111
Ubiquitin thioesterase OTUB2 OTUB2 Tbio Enzyme -1.01946 11.0 252
Ubiquitin carboxyl-terminal hydrolase 5 USP5 Tchem Enzyme -2.22247 166.1 227
Ubiquitin carboxyl-terminal hydrolase 27 USP27X Tdark Enzyme 0.00000 61
Ubiquitin carboxyl-terminal hydrolase 34 USP34 Tbio Enzyme -0.03779 1.93 72
Ubiquitin thioesterase OTUB1 OTUB1 Tbio Enzyme -1.68151 50.0 281
OTU domain-containing protein 5 OTUD5 Tbio Non-IDG -0.89861 6.92 100
OTU domain-containing protein 7A OTUD7A Tbio Non-IDG -0.54041 3.76 78
Deubiquitinating protein VCIP135 VCPIP1 Tbio Non-IDG -0.84731 7.39 80