Development Level

Tbio 5 | 11,651

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
tremors 1 | 39

Disease

psoriasis 5 | 6,694
ovarian cancer 3 | 8,520
Alzheimer's disease 2 | 658
Autosomal recessive predisposition 2 | 1,442
Carcinoma 2 | 11,493
Intellectual disability 2 | 1,016
Parkinson's disease 2 | 392
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
pancreatic cancer 2 | 2,398
primitive neuroectodermal tumor 2 | 3,035
AUTOIMMUNE DISEASE, MULTISYSTEM, WITH FACIAL DYSMORPHISM 1 | 1
Abnormality of metabolism/homeostasis 1 | 134
Acquired scoliosis 1 | 281
Adult onset 1 | 82
Almond-shaped eyes 1 | 23
Anemia 1 | 365
Angelman syndrome 1 | 34
Astrocytoma, Pilocytic 1 | 3,081
Atopic dermatitis 1 | 952
Autistic Disorder 1 | 364
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 1 | 13
Bone marrow hypocellularity 1 | 20
Bradykinesia 1 | 34
Breast cancer 1 | 3,578
Bronchioloalveolar Adenocarcinoma 1 | 14
Cancer 1 | 2,499
Chromosome Breakage 1 | 36
Colonic Neoplasms 1 | 142
Curvature of spine 1 | 282
Decreased platelet count 1 | 111
Dementia 1 | 175
Dull intelligence 1 | 645
Dysgerminoma 1 | 11
Dystonia 1 | 164
Dystonic disease 1 | 106
Endometriosis 1 | 540
Fanconi anemia 1 | 56
Gliosis in the substantia nigra 1 | 3
Hemoglobin low 1 | 124
Hyperreflexia 1 | 209
Hypoplasia of thumb 1 | 26
Increased chromosomal breakage 1 | 27
Irregular hyperpigmentation 1 | 33
Kidney Neoplasms 1 | 37
Learning Disorders 1 | 29
Leprosy 1 | 73
Leukopenia 1 | 72
Liddle syndrome 1 | 14
Lung Neoplasms 1 | 232
Manganese Poisoning 1 | 11
Memory Disorders 1 | 40
Multiple system atrophy 1 | 29
Muscle Rigidity 1 | 49
Nerve Degeneration 1 | 121
Neurodegenerative disease 1 | 414
Ovarian Cysts 1 | 41
Ovarian Neoplasms 1 | 102
Ovarian papillary adenocarcinoma 1 | 5
PARKINSON DISEASE 19, JUVENILE-ONSET 1 | 10
PARKINSON DISEASE, LATE-ONSET 1 | 20
Pancytopenia 1 | 45
Parkinson Disease 1 | 64
Parkinsonian Disorders 1 | 56
Pick disease 1 | 1,894
Postural instability 1 | 19
Pyridoxine-responsive sideroblastic anemia 1 | 17
Radial aplasia/hypoplasia 1 | 29
Rheumatoid arthritis 1 | 1,191
Secondary Parkinson Disease 1 | 10
Short palpebral fissure 1 | 38
TREMOR, HEREDITARY ESSENTIAL, 1 1 | 2
Thrombocytopenia 1 | 197
Toxic encephalopathy 1 | 141
Tremor 1 | 113
Young onset Parkinson disease 1 | 10
adrenocortical carcinoma 1 | 1,428
ductal carcinoma in situ 1 | 1,745
esophageal adenocarcinoma 1 | 737
group 3 medulloblastoma 1 | 4,104
hypopigmented skin patch 1 | 59
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
lung cancer 1 | 4,740
lung carcinoma 1 | 2,843
medulloblastoma 1 | 720
nasopharyngeal carcinoma 1 | 1,058
pituitary cancer 1 | 1,972
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370
spina bifida 1 | 1,074

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Non-IDG 3 | 12,091
Enzyme 2 | 4,145

GO Process

protein K29-linked ubiquitinat... 5 | 5
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 D4 UBE2D4 Tbio Non-IDG -0.10266 1.25 129
E3 ubiquitin-protein ligase Itchy homolog ITCH Tbio Enzyme -2.06799 109.7 232
Ubiquitin-conjugating enzyme E2 T UBE2T Tbio Non-IDG -1.23235 18.8 199
Ubiquitin-conjugating enzyme E2 S UBE2S Tbio Non-IDG -2.36597 158.3 384
E3 ubiquitin-protein ligase parkin PRKN Tbio Enzyme -2.99618 1004.1 533