Development Level

Tbio 41 | 11,178
Tchem 19 | 1,885
Tclin 8 | 612
Tdark 6 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 4 | 499
enlarged heart 3 | 210
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
decreased basophil cell number 2 | 16
decreased bone mineral density 2 | 126
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
edema 2 | 59
hydrometra 2 | 53
hypoactivity 2 | 132
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
cataract 1 | 92
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
scaly skin 1 | 4
small epididymis 1 | 3
small spleen 1 | 19
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 59 | 11,192
osteosarcoma 45 | 7,766
ovarian cancer 45 | 8,297
medulloblastoma, large-cell 36 | 6,086
glioblastoma 30 | 5,635
psoriasis 30 | 6,514
Breast cancer 28 | 3,469
atypical teratoid / rhabdoid tumor 27 | 4,971
lung cancer 26 | 4,607
Cancer 23 | 2,388
malignant mesothelioma 20 | 3,135
ependymoma 19 | 4,559
pancreatic cancer 19 | 2,322
Kidney cancer 18 | 2,548
adult high grade glioma 18 | 3,701
lung carcinoma 18 | 2,755
group 3 medulloblastoma 17 | 4,002
invasive ductal carcinoma 17 | 2,867
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,911
pituitary cancer 17 | 1,915
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,204
primitive neuroectodermal tumor 16 | 2,957
Epilepsy 15 | 775
Intellectual disability 15 | 998
group 4 medulloblastoma 15 | 1,806
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,902
oligodendroglioma 15 | 2,768
subependymal giant cell astrocytoma 15 | 2,230
Astrocytoma, Pilocytic 14 | 3,006
Autosomal recessive predisposition 14 | 1,407
Cognitive delay 14 | 596
Global developmental delay 14 | 596
Mental and motor retardation 14 | 596
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,872
non-small cell lung cancer 14 | 2,799
spina bifida 14 | 1,053
Muscle hypotonia 13 | 562
astrocytic glioma 13 | 2,530
colon cancer 13 | 1,428
cystic fibrosis 13 | 1,629
Pick disease 12 | 1,856
Short stature 12 | 514
ulcerative colitis 12 | 1,765
Dull intelligence 11 | 634
Low intelligence 11 | 634
Mental Retardation 11 | 634
Mental deficiency 11 | 634
Poor school performance 11 | 634
Schizophrenia 11 | 1,136
lung adenocarcinoma 11 | 2,627
Seizures 10 | 584
acute quadriplegic myopathy 10 | 1,133
diabetes mellitus 10 | 1,683
primary pancreatic ductal adenocarcinoma 10 | 1,071
tuberculosis 10 | 1,963
Bipolar Disorder 9 | 646
Cerebellar Ataxia 9 | 302
Liver cancer 9 | 589
Rheumatoid arthritis 9 | 1,156
astrocytoma 9 | 1,113
ductal carcinoma in situ 9 | 1,686
interstitial cystitis 9 | 2,237
juvenile dermatomyositis 9 | 1,147
Hypoplastic mandible condyle 8 | 273
Mandibular hypoplasia 8 | 273
Micrognathism 8 | 273
Multiple myeloma 8 | 1,296
acute myeloid leukemia 8 | 760
adrenocortical carcinoma 8 | 1,385
breast carcinoma 8 | 1,589
Colorectal Neoplasms 7 | 235
Craniofacial Abnormalities 7 | 141
Cryptorchidism 7 | 287
Electroencephalogram abnormal 7 | 100
Endometrial cancer 7 | 301
Hypertension 7 | 372
Obesity 7 | 655
Orbital separation excessive 7 | 240
active ulcerative colitis 7 | 736
cutaneous lupus erythematosus 7 | 1,016
Autistic Disorder 6 | 358
Blepharoptosis 6 | 229
Depressive disorder 6 | 401
Dilated ventricles (finding) 6 | 119
Failure to gain weight 6 | 359
Feeding difficulties in infancy 6 | 174
Hypertensive disease 6 | 278
Hypoplastic feet 6 | 66
Liver Cirrhosis, Experimental 6 | 733
Long philtrum 6 | 137
Pediatric failure to thrive 6 | 359
Recurrent respiratory infections 6 | 138
Splenomegaly 6 | 186
Strabismus 6 | 265
Waldenstrons macroglobulinemia 6 | 742
chronic rhinosinusitis 6 | 505
non primary Sjogren syndrome sicca 6 | 861
pediatric high grade glioma 6 | 1,035
posterior fossa group A ependymoma 6 | 456
urothelial carcinoma 6 | 303

Tissue

Digestive Tract 73 | 17,369
Endocrine System 73 | 18,159
Female tissues 72 | 17,400
Urinary Tract 72 | 16,678
Blood and immune system 71 | 16,909
Male tissues 71 | 17,142
Skin and soft tissues 71 | 17,230
Cardiovascular System 69 | 15,192
Liver and Pancreas 69 | 16,750
Nervous System 69 | 16,725
Respiratory system 69 | 16,393

Target Family

Non-IDG 26 | 12,091
Enzyme 14 | 4,145
Transcription Factor 14 | 1,400
Kinase 8 | 634
Epigenetic 4 | 242
Ion Channel 3 | 344
TF/Epigenetic 2 | 38
Transporter 2 | 473
Nuclear Receptor 1 | 48

GO Process

post-embryonic development 74 | 74
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
Homeobox protein EMX1 EMX1 Tbio Transcription Factor -1.76097 51.7 154
MORC family CW-type zinc finger protein 3 MORC3 Tbio Non-IDG -1.61241 36.6 61
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109
Lysine-specific demethylase 5B KDM5B Tchem TF/Epigenetic -2.20655 168.1 252
Necdin NDN Tbio Non-IDG -2.22453 171.0 277
Cyclic AMP-dependent transcription factor ATF-5 ATF5 Tbio Transcription Factor -1.80759 80.3 220
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230