Development Level

Tchem 11 | 1,598
Tbio 10 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
convulsive seizures 1 | 13
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
polycystic kidney 1 | 15

Disease

Carcinoma 22 | 11,493
Cancer 18 | 2,499
ovarian cancer 18 | 8,520
malignant mesothelioma 17 | 3,232
psoriasis 17 | 6,694
glioblastoma 16 | 5,792
non-small cell lung cancer 16 | 2,890
osteosarcoma 15 | 7,950
medulloblastoma, large-cell 13 | 6,241
lung cancer 12 | 4,740
ulcerative colitis 12 | 1,819
lung carcinoma 11 | 2,843
pancreatic cancer 11 | 2,398
cystic fibrosis 10 | 1,696
diabetes mellitus 10 | 1,728
Astrocytoma, Pilocytic 9 | 3,081
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
tuberculosis 9 | 2,010
Breast cancer 8 | 3,578
Depressive disorder 8 | 409
Vascular disease 8 | 319
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
Asthma 7 | 385
Bipolar Disorder 7 | 666
Mental Depression 7 | 333
Schizophrenia 7 | 1,160
astrocytic glioma 7 | 2,597
cutaneous lupus erythematosus 7 | 1,057
primary pancreatic ductal adenocarcinoma 7 | 1,109
Breast Neoplasms 6 | 445
Colorectal Neoplasms 6 | 243
Kidney disease 6 | 430
Mammary Neoplasms 6 | 425
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
dermatomyositis 6 | 966
gastric carcinoma 6 | 807
group 3 medulloblastoma 6 | 4,104
juvenile dermatomyositis 6 | 1,187
mucosa-associated lymphoid tissue lymphoma 6 | 484
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
Arthritis 5 | 290
Autosomal recessive predisposition 5 | 1,442
Chemical and Drug Induced Liver Injury 5 | 195
Endometriosis 5 | 540
Hypertension 5 | 396
Kidney cancer 5 | 2,613
Liver Cirrhosis, Experimental 5 | 769
Melanoma 5 | 711
Prostatic Neoplasms 5 | 495
Reperfusion Injury 5 | 86
adult high grade glioma 5 | 3,801
aldosterone-producing adenoma 5 | 665
ductal carcinoma in situ 5 | 1,745
periodontitis 5 | 293
Alzheimer's disease 4 | 658
Anemia 4 | 365
Atherosclerosis 4 | 291
Brain Ischemia 4 | 110
Cardiomegaly 4 | 116
Cerebrovascular disease 4 | 238
Congenital heart disease 4 | 93
Duchenne muscular dystrophy 4 | 601
Heart disease 4 | 306
Heart failure 4 | 162
Hyperglycemia 4 | 137
Hypertensive disease 4 | 292
Inflammation 4 | 120
Liver cancer 4 | 604
Liver disease 4 | 237
Lung disease 4 | 142
Major Depressive Disorder 4 | 301
Myocardial Infarction 4 | 151
Myocardial Ischemia 4 | 169
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Obesity 4 | 678
Osteoporosis 4 | 363
Ovarian Neoplasms 4 | 102
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Polycystic ovary syndrome 4 | 360
Skin Neoplasms 4 | 69
Unipolar Depression 4 | 250
astrocytoma 4 | 1,146
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058
ovarian neoplasm 4 | 99
pediatric high grade glioma 4 | 1,064

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Respiratory system 27 | 16,393
Nervous System 26 | 16,725
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 23 | 15,192

Target Family

Non-IDG 11 | 12,091
Enzyme 5 | 4,145
Transcription Factor 5 | 1,400
GPCR 3 | 408
Kinase 2 | 634
Nuclear Receptor 1 | 48

GO Process

positive regulation of vascula... 27 | 27
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Extracellular sulfatase Sulf-2 SULF2 Tbio Enzyme -1.74398 67.0 221
Extracellular sulfatase Sulf-1 SULF1 Tbio Enzyme -1.90276 92.2 61
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.06834 12504.5 731
Eukaryotic translation initiation factor 2-alpha kinase 3 EIF2AK3 Tchem Kinase -3.05781 896.8 450
Vascular endothelial growth factor receptor 3 FLT4 Tclin Kinase -2.72966 518.8 744
C-X-C motif chemokine 17 CXCL17 Tbio Non-IDG -1.29313 21.8 50
Cytochrome P450 1B1 CYP1B1 Tchem Non-IDG -2.93702 904.4 260
Transcription factor GATA-4 GATA4 Tbio Transcription Factor -2.90202 763.9 496
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542