Development Level

Tbio 36 | 11,445
Tchem 13 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating sodium l... 2 | 22
increased circulating free fat... 2 | 20
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
female infertility 1 | 60
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 30 | 11,493
ovarian cancer 30 | 8,520
lung cancer 25 | 4,740
osteosarcoma 25 | 7,950
psoriasis 23 | 6,694
Cancer 21 | 2,499
medulloblastoma, large-cell 17 | 6,241
glioblastoma 16 | 5,792
Multiple myeloma 15 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Breast cancer 13 | 3,578
Kidney cancer 13 | 2,613
lung carcinoma 12 | 2,843
atypical teratoid / rhabdoid tumor 11 | 5,112
diabetes mellitus 11 | 1,728
subependymal giant cell astrocytoma 11 | 2,287
ependymoma 10 | 4,679
malignant mesothelioma 9 | 3,232
adult high grade glioma 8 | 3,801
astrocytoma 8 | 1,146
breast carcinoma 8 | 1,638
group 3 medulloblastoma 8 | 4,104
juvenile dermatomyositis 8 | 1,187
tuberculosis 8 | 2,010
Autosomal recessive predisposition 7 | 1,442
Multiple Sclerosis 7 | 540
Schizophrenia 7 | 1,160
acute quadriplegic myopathy 7 | 1,158
cutaneous lupus erythematosus 7 | 1,057
invasive ductal carcinoma 7 | 2,951
primitive neuroectodermal tumor 7 | 3,035
Asthma 6 | 385
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hyperreflexia 6 | 209
Intellectual disability 6 | 1,016
Mental and motor retardation 6 | 608
Rheumatoid arthritis 6 | 1,191
Short stature 6 | 531
Systemic lupus erythematosus 6 | 194
Waldenstrons macroglobulinemia 6 | 765
colon cancer 6 | 1,478
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
ulcerative colitis 6 | 1,819
Dull intelligence 5 | 645
Highly variable severity 5 | 157
Hypersensitivity reaction type II disease 5 | 253
Inflammatory bowel disease 5 | 151
Influenza 5 | 142
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Small head 5 | 374
Strabismus 5 | 270
Variable expressivity 5 | 157
active Crohn's disease 5 | 922
astrocytic glioma 5 | 2,597
gastric carcinoma 5 | 807
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
primary Sjogren syndrome 5 | 735
Adenocarcinoma of lung 4 | 142
Allergic hypersensitivity disease 4 | 126
Arthritis 4 | 290
Astrocytoma, Pilocytic 4 | 3,081
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Broad flat nasal bridge 4 | 236
Cataract 4 | 297
Cerebral atrophy 4 | 178
Crohn's disease 4 | 321
Dysarthria 4 | 192
Endometrial cancer 4 | 311
Glaucoma 4 | 239
Hereditary spherocytosis type 5 4 | 12
Hypoplasia of corpus callosum 4 | 90
Hypoplastic mandible condyle 4 | 275
Immune system cancer 4 | 140
Lens Opacities 4 | 231
Mandibular hypoplasia 4 | 275
Melanoma 4 | 711
Micrognathism 4 | 275
Microphthalmia with limb anomalies 4 | 40
Muscle Spasticity 4 | 195
Nasal bridge wide 4 | 236
Progressive disorder 4 | 142
Stomach Neoplasms 4 | 300
Vascular disease 4 | 319
acute myeloid leukemia 4 | 783
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972

Tissue

Digestive Tract 48 | 17,369
Liver and Pancreas 48 | 16,750
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Blood and immune system 47 | 16,909
Cardiovascular System 47 | 15,192
Endocrine System 47 | 18,159
Female tissues 47 | 17,400
Male tissues 47 | 17,142
Nervous System 47 | 16,725
Respiratory system 47 | 16,393

Target Family

Enzyme 24 | 4,145
Non-IDG 12 | 12,091
Transcription Factor 7 | 1,400
Kinase 4 | 634
Epigenetic 2 | 242

GO Process

positive regulation of type I ... 49 | 49
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

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